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tjp2b tight junction protein 2b (zona occludens 2) [ Danio rerio (zebrafish) ]

Gene ID: 436639, updated on 9-Dec-2024

Summary

Official Symbol
tjp2bprovided by ZNC
Official Full Name
tight junction protein 2b (zona occludens 2)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-58
See related
Ensembl:ENSDARG00000023443 AllianceGenome:ZFIN:ZDB-GENE-040718-58
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb62b09; zgc:92094; wu:fb62b09
Summary
Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including establishment of endothelial intestinal barrier; positive regulation of blood-brain barrier permeability; and protein localization to cell-cell junction. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including digestive system; immature eye; nervous system; pronephros; and segmental plate. Human ortholog(s) of this gene implicated in disease of metabolism and progressive familial intrahepatic cholestasis 4. Orthologous to human TJP2 (tight junction protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See tjp2b in Genome Data Viewer
Location:
chromosome: 8
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (11370187..11542848)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (11398418..11456135)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type I, beta b Neighboring gene frataxin Neighboring gene piercer of microtubule wall 1 Neighboring gene microRNA 126a Neighboring gene formin binding protein 1a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tight junction protein ZO-2b
Names
tjp2.2
zo-2.2
zona occludens 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430967.1NP_001417896.1  tight junction protein ZO-2b isoform 1

    Status: VALIDATED

    Source sequence(s)
    CR361566, FQ377600
  2. NM_001430968.1NP_001417897.1  tight junction protein ZO-2b isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR361566, FQ377912
    UniProtKB/TrEMBL
    Q6DHS7
  3. NM_001430969.1NP_001417898.1  tight junction protein ZO-2b isoform 3

    Status: VALIDATED

    Source sequence(s)
    CR361566, FQ377600
    UniProtKB/TrEMBL
    Q6DHS7
    Related
    ENSDARP00000086787.5, ENSDART00000092355.7

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    11370187..11542848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222917.1XP_068079018.1  tight junction protein ZO-2b isoform X1

  2. XM_068222919.1XP_068079020.1  tight junction protein ZO-2b isoform X3

  3. XM_068222923.1XP_068079024.1  tight junction protein ZO-2b isoform X7

    UniProtKB/TrEMBL
    Q6DHS7
  4. XM_068222921.1XP_068079022.1  tight junction protein ZO-2b isoform X5

  5. XM_068222924.1XP_068079025.1  tight junction protein ZO-2b isoform X8

    UniProtKB/TrEMBL
    Q6DHS7
    Related
    ENSDARP00000026529.9, ENSDART00000018739.10
  6. XM_068222920.1XP_068079021.1  tight junction protein ZO-2b isoform X4

  7. XM_068222918.1XP_068079019.1  tight junction protein ZO-2b isoform X2

  8. XM_068222922.1XP_068079023.1  tight junction protein ZO-2b isoform X6

    Related
    ENSDARP00000112709.1, ENSDART00000136184.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001002366.1: Suppressed sequence

    Description
    NM_001002366.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.