elocb elongin C paralog b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: elocbprovided by ZNC
Official Full Name: elongin C paralog bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-138
See related: Ensembl:ENSDARG00000045359 AllianceGenome:ZFIN:ZDB-GENE-040718-138
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TCEB1; tceb1b; fb09f09; zgc:92635; wu:fb09f09; zgc:111990
Summary: Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within translational elongation. Predicted to be part of elongin complex. Orthologous to human ELOC (elongin C). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (30245853..30249737, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (30262320..30266204, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicate that antagonistic regulation of gene expression by PAF1Cand p-TEFb plays a crucial role in oligodendrocyte development in the CNS.
Title: Antagonistic regulation of PAF1C and p-TEFb is required for oligodendrocyte differentiation.
P-TEFb has a role in coupling transcription elongation with alternative splicing, and maintaining core 7SK snRNP is essential for vertebrate development
Title: 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational elongation	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of elongin complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: elongin C paralog b

Names: transcription elongation factor B (SIII), polypeptide 1; transcription elongation factor B (SIII), polypeptide 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002440.2 → NP_001002440.2 elongin C paralog b

See identical proteins and their annotated locations for NP_001002440.2

Status: PROVISIONAL

Source sequence(s)

BC095636

UniProtKB/TrEMBL

B2GSE2, Q502M9

Related

ENSDARP00000118581.1, ENSDART00000142575.3

Conserved Domains (1) summary

cd18321
Location:18 → 112

BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins