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atp2b3a ATPase plasma membrane Ca2+ transporting 3a [ Danio rerio (zebrafish) ]

Gene ID: 436745, updated on 27-Dec-2024

Summary

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Official Symbol
atp2b3aprovided by ZNC
Official Full Name
ATPase plasma membrane Ca2+ transporting 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-174
See related
Ensembl:ENSDARG00000043474 AllianceGenome:ZFIN:ZDB-GENE-040718-174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
atp2b3; pmca3a; zgc:92885; wu:fk54d07
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and P-type calcium transporter activity. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in plasma membrane. Is expressed in blood; liver; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1. Orthologous to human ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See atp2b3a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (14003039..14052499, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (13964610..14014801, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-110g5.4 Neighboring gene insulin-like growth factor 3 Neighboring gene UDP glucuronosyltransferase 5 family, polypeptide E1 Neighboring gene death effector domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression and water calcium dependence of calcium transporter isoforms in zebrafish gill mitochondrion-rich cells. Liao BK, et al. BMC Genomics, 2007 Oct 4. PMID 17915033, Free PMC Article
  2. Heat Failure Phenotypes Induced by Knockdown of DAPIT in Zebrafish: A New Insight into Mechanism of Dilated Cardiomyopathy. Nagata Y, et al. Sci Rep, 2017 Dec 12. PMID 29234032, Free PMC Article
  3. Transcriptomic Profiling Revealed Signaling Pathways Associated with the Spawning of Female Zebrafish under Cold Stress. Ge G, et al. Int J Mol Sci, 2022 Jul 6. PMID 35886843, Free PMC Article
  4. Toxicological assessment of trace β-diketone antibiotic mixtures on zebrafish (Danio rerio) by proteomic analysis. Yin X, et al. PLoS One, 2014. PMID 25062015, Free PMC Article
  5. Effects of dietary methylmercury on the zebrafish brain: histological, mitochondrial, and gene transcription analyses. Cambier S, et al. Biometals, 2012 Feb. PMID 21947502

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
plasma membrane calcium-transporting ATPase 3a
Names
ATPase, Ca++ transporting, plasma membrane 3
ATPase, Ca++ transporting, plasma membrane 3a
plasma membrane calcium ATPase 3
NP_001002472.2
NP_001352362.1
XP_005166875.1
XP_005166876.1
XP_005166877.1
XP_005166879.1
XP_021333914.1
XP_021333915.1
XP_068079027.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002472.3 → NP_001002472.2  plasma membrane calcium-transporting ATPase 3a isoform 2

    See identical proteins and their annotated locations for NP_001002472.2

    Status: VALIDATED

    Source sequence(s)
    BX248385
    UniProtKB/TrEMBL
    B0S5H1, B2CZB9
    Related
    ENSDARP00000087549.4, ENSDART00000093117.6
    Conserved Domains (7) summary
    TIGR01517
    Location:23 → 1060
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:164 → 462
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:877 → 1055
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:57 → 116
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:1100 → 1144
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:605 → 803
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:523 → 612
    Cation_ATPase; Cation transport ATPase (P-type)

  2. NM_001365433.1 → NP_001352362.1  plasma membrane calcium-transporting ATPase 3a isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX248385
    UniProtKB/TrEMBL
    A0A8M6Z7L0
    Conserved Domains (2) summary
    pfam12424
    Location:1122 → 1167
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:23 → 1082
    E1-E2_ATPase; E1-E2 ATPase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    14003039..14052499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478239.2 → XP_021333914.1  plasma membrane calcium-transporting ATPase 3a isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q9N1
    Related
    ENSDARP00000119407.1, ENSDART00000135811.3
    Conserved Domains (2) summary
    pfam12424
    Location:1100 → 1146
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:23 → 1060
    E1-E2_ATPase; E1-E2 ATPase

  2. XM_005166819.5 → XP_005166876.1  plasma membrane calcium-transporting ATPase 3a isoform X2

    UniProtKB/TrEMBL
    A0A8M2BE97
    Conserved Domains (7) summary
    TIGR01517
    Location:23 → 1060
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:164 → 462
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:877 → 1055
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:57 → 116
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:1100 → 1176
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:605 → 803
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:523 → 612
    Cation_ATPase; Cation transport ATPase (P-type)

  3. XM_068222926.1 → XP_068079027.1  plasma membrane calcium-transporting ATPase 3a isoform X7

  4. XM_005166820.5 → XP_005166877.1  plasma membrane calcium-transporting ATPase 3a isoform X3

    UniProtKB/TrEMBL
    A0A8M2BEB3
    Conserved Domains (7) summary
    TIGR01517
    Location:23 → 1082
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:164 → 484
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:899 → 1077
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:57 → 116
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:1122 → 1169
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:627 → 825
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:545 → 634
    Cation_ATPase; Cation transport ATPase (P-type)

  5. XM_005166818.5 → XP_005166875.1  plasma membrane calcium-transporting ATPase 3a isoform X1

    UniProtKB/TrEMBL
    A0A8M2BEB4
    Conserved Domains (7) summary
    TIGR01517
    Location:23 → 1082
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:164 → 484
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:899 → 1077
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:57 → 116
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:1122 → 1198
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:627 → 825
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:545 → 634
    Cation_ATPase; Cation transport ATPase (P-type)

  6. XM_021478240.2 → XP_021333915.1  plasma membrane calcium-transporting ATPase 3a isoform X6

    UniProtKB/TrEMBL
    A0A8M9QIJ9
    Conserved Domains (2) summary
    pfam12424
    Location:1100 → 1145
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:23 → 1060
    E1-E2_ATPase; E1-E2 ATPase

  7. XM_005166822.5 → XP_005166879.1  plasma membrane calcium-transporting ATPase 3a isoform X5

    UniProtKB/TrEMBL
    A0A8M2BE74
    Conserved Domains (7) summary
    TIGR01517
    Location:23 → 1082
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:164 → 484
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:899 → 1077
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:57 → 116
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:1122 → 1166
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:627 → 825
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:545 → 634
    Cation_ATPase; Cation transport ATPase (P-type)
Nucleotide Protein
Heading Accession and Version

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