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psmb10 proteasome 20S subunit beta 10 [ Danio rerio (zebrafish) ]

Gene ID: 436816, updated on 4-Jan-2025

Summary

Official Symbol
psmb10provided by ZNC
Official Full Name
proteasome 20S subunit beta 10provided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-278
See related
Ensembl:ENSDARG00000043781 AllianceGenome:ZFIN:ZDB-GENE-040718-278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
beta2i; zgc:92791
Summary
Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within proteolysis involved in protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 5. Orthologous to human PSMB10 (proteasome 20S subunit beta 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See psmb10 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (77207693..77218584, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (75630955..75651464, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 585A-like Neighboring gene oocyte zinc finger protein XlCOF6-like Neighboring gene zinc finger protein 239-like Neighboring gene NLR family CARD domain-containing protein 3-like Neighboring gene si:dkey-172k15.13 Neighboring gene si:dkey-172k15.5 Neighboring gene zgc:174310

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
proteasome subunit beta type-10
Names
proteasome subunit beta 10
NP_001002543.2
NP_001315481.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002543.2NP_001002543.2  proteasome subunit beta type-10

    Status: VALIDATED

    Source sequence(s)
    CU467646
    UniProtKB/TrEMBL
    A0A8M1PA63, F1QR78
    Related
    ENSDARP00000090716.2, ENSDART00000099943.5
    Conserved Domains (3) summary
    COG0638
    Location:40224
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03763
    Location:43231
    proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    pfam12465
    Location:237270
    Pr_beta_C; Proteasome beta subunits C terminal
  2. NM_001328552.2NP_001315481.1  proteasome subunit beta type-10

    Status: VALIDATED

    Source sequence(s)
    CU467646
    UniProtKB/TrEMBL
    A0A8M1PA63, F1QR78
    Related
    ENSDARP00000143228.1, ENSDART00000174325.2
    Conserved Domains (3) summary
    COG0638
    Location:40224
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03763
    Location:43231
    proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    pfam12465
    Location:237270
    Pr_beta_C; Proteasome beta subunits C terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    77207693..77218584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)