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notum1b notum, palmitoleoyl-protein carboxylesterase b [ Danio rerio (zebrafish) ]

Gene ID: 436917, updated on 18-Sep-2024

Summary

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Official Symbol
notum1bprovided by ZNC
Official Full Name
notum, palmitoleoyl-protein carboxylesterase bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-391
See related
AllianceGenome:ZFIN:ZDB-GENE-040718-391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92474
Summary
Predicted to enable palmitoleyl hydrolase activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and protein depalmitoleylation. Orthologous to human NOTUM (notum, palmitoleoyl-protein carboxylesterase). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See notum1b in Genome Data Viewer
Location:
chromosome: 11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (45244612..45252032, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (44830218..44833697, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496743 Neighboring gene Fc receptor-like protein 5 Neighboring gene uncharacterized LOC137496744 Neighboring gene transmembrane channel-like 8 Neighboring gene transmembrane channel-like 6b Neighboring gene ASPSCR1 tether for SLC2A4, UBX domain containing Neighboring gene pyrroline-5-carboxylate reductase 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A zebrafish Notum homolog specifically blocks the Wnt/β-catenin signaling pathway. Flowers GP, et al. Development, 2012 Jul. PMID 22669824, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoleyl hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein depalmitoleylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
inactive palmitoleoyl-protein carboxylesterase notum1b
Names
notum pectinacetylesterase 1b
notum pectinacetylesterase homolog 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423935.1 → NP_001410864.1  inactive palmitoleoyl-protein carboxylesterase notum1b precursor

    Status: VALIDATED

    Source sequence(s)
    MW118490

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    45244612..45252032 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001002644.1: Suppressed sequence

    Description
    NM_001002644.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DFZ6.1 GenPept UniProtKB/Swiss-Prot:Q6DFZ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials