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bcat2 branched chain amino-acid transaminase 2, mitochondrial [ Danio rerio (zebrafish) ]

Gene ID: 436949, updated on 2-Nov-2024

Summary

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Official Symbol
bcat2provided by ZNC
Official Full Name
branched chain amino-acid transaminase 2, mitochondrialprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-425
See related
Ensembl:ENSDARG00000054849 AllianceGenome:ZFIN:ZDB-GENE-040718-425
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb37h12; zgc:91919; wu:fb37h12
Summary
Predicted to enable branched-chain-amino-acid transaminase activity. Predicted to be involved in L-leucine biosynthetic process and L-valine biosynthetic process. Predicted to act upstream of or within amino acid biosynthetic process; branched-chain amino acid biosynthetic process; and lipid metabolic process. Predicted to be active in mitochondrion. Is expressed in liver and muscle. Human ortholog(s) of this gene implicated in hypervalinemia and hyperleucine-isoleucinemia. Orthologous to human BCAT2 (branched chain amino acid transaminase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See bcat2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (29949984..29968050, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (29819142..29837208, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene granulin a antisense Neighboring gene granulin a Neighboring gene interferon-induced protein 35 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mitochondrial Fatty Acid β-Oxidation Inhibition Promotes Glucose Utilization and Protein Deposition through Energy Homeostasis Remodeling in Fish. Li LY, et al. J Nutr, 2020 Sep 1. PMID 32720689, Free PMC Article
  2. Peroxisomal proliferator-activated receptor α-b deficiency induces the reprogramming of nutrient metabolism in zebrafish. Li LY, et al. J Physiol, 2020 Oct. PMID 32710562
  3. A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting. Hugo SE, et al. Genes Dev, 2012 Feb 1. PMID 22302940, Free PMC Article
  4. Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. Nakajima H, et al. PLoS One, 2011. PMID 22046393, Free PMC Article
  5. The dysfunction of hormone-sensitive lipase induces lipid deposition and reprogramming of nutrient metabolism in fish. Wang JG, et al. Br J Nutr, 2023 Aug 28. PMID 36408747

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-isoleucine-2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-leucine-2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-valine-2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables branched-chain-amino-acid transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables branched-chain-amino-acid transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-leucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-valine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within branched-chain amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
branched-chain-amino-acid aminotransferase, mitochondrial
Names
branched chain aminotransferase 2, mitochondrial
NP_001002676.2
NP_001296456.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002676.2 → NP_001002676.2  branched-chain-amino-acid aminotransferase, mitochondrial isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CR384107
    UniProtKB/TrEMBL
    A0A8M1N0V9, E9QCQ6, F1QLF8
    Related
    ENSDARP00000071587.3, ENSDART00000077119.3
    Conserved Domains (2) summary
    PRK13357
    Location:50 → 397
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:100 → 395
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

  2. NM_001309527.1 → NP_001296456.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end of the coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    CR384107
    UniProtKB/TrEMBL
    A0A8M1P782, E9QFU8
    Related
    ENSDARP00000122776.1, ENSDART00000139310.3
    Conserved Domains (2) summary
    PRK13357
    Location:35 → 382
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:85 → 380
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    29949984..29968050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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