nej nejire [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nejprovided by FlyBase
Official Full Name: nejireprovided by FlyBase
Primary source: FLYBASE:FBgn0261617
Locus tag: Dmel_CG15319
See related: AllianceGenome:FB:FBgn0261617
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0147981.11; anon-WO03040301.89; cbp; Cbp; CBP; CBP/p300; CBP_; CG15319; CG15321; Crbp; dCBP; dKAT3; dmCBP; Dmel\CG15319; l(1)G0112; l(1)G0350; l(1)G0470; Nej; nej CBP; Nejire; p300; P300; p300/CBP
Old locus tag: Dmel_CG15321
Summary: Enables several functions, including H3 histone acetyltransferase activity; histone methyltransferase binding activity; and transcription coactivator activity. Involved in several processes, including histone modification; nervous system development; and regulation of canonical Wnt signaling pathway. Located in nucleus and polytene chromosome. Part of histone acetyltransferase complex and histone methyltransferase complex. Is expressed in several structures, including adult brain cell body rind; embryonic/larval nervous system; and peripheral glial cell. Used to study Rubinstein-Taybi syndrome and alcohol use disorder. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; acute myeloid leukemia; colorectal cancer; and congestive heart failure. Orthologous to several human genes including CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 8F7-8F9; 1-29 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (9665442..9687066, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (9559475..9581099, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Drosophila melanogaster Lifespan Is Regulated by nejire Gene Expression in Peripheral Tissues and Nervous System].
Title: [Drosophila melanogaster Lifespan Is Regulated by nejire Gene Expression in Peripheral Tissues and Nervous System].
Resveratrol ameliorates myocardial fibrosis by regulating Sirt1/Smad3 deacetylation pathway in rat model with dilated cardiomyopathy.
Title: Resveratrol ameliorates myocardial fibrosis by regulating Sirt1/Smad3 deacetylation pathway in rat model with dilated cardiomyopathy.
Shaggy functions downstream of dMyc and their concurrent downregulation confers additive rescue against tau toxicity in Drosophila.
Title: Shaggy functions downstream of dMyc and their concurrent downregulation confers additive rescue against tau toxicity in Drosophila.
Trx, Ash1, and CBP proteins are required for the correct chromosome segregation and that Ash1 and CBP mediate for Cid/CENP-A recruitment at centromeres through post-translational histone modifications. Centromeric H3 histone is consistently acetylated in K27 by CBP and that nej and ash1 silencing respectively causes a decrease in H3K27 acetylation and H3K4 methylation along with an impairment of Cid loading.
Title: A role of the Trx-G complex in Cid/CENP-A deposition at Drosophila melanogaster centromeres.
histone H3 lysine acetylation catalysed by the acetyltransferases dCBP, contributes to Drosophila learning, likely by controlling the expression of specific genes.
Title: Histone acetyltransferase CBP-related H3K23 acetylation contributes to courtship learning in Drosophila.
With respect to the histone-to-protamine transition, study proposes that Nejire regulates transcript levels for sperm relevant proteins in spermatocytes and in directly or indirectly acetylation of H3K18 and H3K27 for fully efficient histone degradation.
Title: Nejire/dCBP-mediated histone H3 acetylation during spermatogenesis is essential for male fertility in Drosophila melanogaster.
CBP directly stimulates both RNA polymerase II recruitment and the ability to traverse the first nucleosome, thereby promoting transcription of most genes.
Title: CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II.
En forms a complex with Nejire (Nej), the Drosophila ortholog of histone acetyltransferase CBP/p300, and directs Nej to this cis-regulatory region where Nej functions as the co-activator for dpp expression.
Title: Engrailed acts with Nejire to control decapentaplegic expression in the Drosophila ovarian stem cell niche.
Drosophila genetic experiments demonstrated interaction between SMARCAD1/Etl1 and CBP/nej during development. The interplay between the remodeling activity of SMARCAD1 and histone acetylation by CBP sheds light on the function of chromatin and the genome-integrity network.
Title: SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation.
a novel activity of polycomb: inhibition of the histone acetylation activity of CREB-binding protein, is identified.
Title: Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0433 (e-PCR)
- UniSTS:29297

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c9678639-9678154 mobile_element_type = transposon:TART-B{}5270
Loc: c9679157-9678736 mobile_element_type = transposon:TART-A{}5266

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cAMP response element binding protein binding	TAS Traceable Author Statement more info	PubMed
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K18 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K27 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA replication checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R3/R4 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R7 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemopoiesis	TAS Traceable Author Statement more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic nuclear division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of histone methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nejire

Names: CBP histone acetyltransferase; CBP/Nejire; CG15319-PB; CG15319-PC; CG15319-PD; CG15319-PE; CREB binding protein; CREB-binding protein; cyclic AMP response element binding protein; drosophila CREB-binding; drosophila CREB-binding protein; lethal (1) G0112; lethal (1) G0350; lethal (1) G0470; nej-PB; nej-PC; nej-PD; nej-PE; protein

NP_001188575.1

EC 2.3.1.48

NP_001188576.1

EC 2.3.1.48

NP_001259387.1

EC 2.3.1.48

NP_524642.2

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

9665442..9687066 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001201647.2 → NP_001188576.1 nejire, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188576.1

Status: REVIEWED

UniProtKB/TrEMBL

O01368, Q9W321

Conserved Domains (7) summary

cd05495
Location:1699 → 1806

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:524 → 594

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:2333 → 2373

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1818 → 1900

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1902 → 1933

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam02172
Location:940 → 1018

KIX; KIX domain

pfam08214
Location:1964 → 2277

HAT_KAT11; Histone acetylation protein
NM_001272458.1 → NP_001259387.1 nejire, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259387.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PH39, O01368

Conserved Domains (7) summary

cd05495
Location:1699 → 1806

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:524 → 594

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:2323 → 2363

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1818 → 1890

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1892 → 1923

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam02172
Location:940 → 1018

KIX; KIX domain

pfam08214
Location:1954 → 2267

HAT_KAT11; Histone acetylation protein
NM_001201646.2 → NP_001188575.1 nejire, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188575.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MS40, O01368

Conserved Domains (7) summary

cd05495
Location:1705 → 1812

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:530 → 600

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:2339 → 2379

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1824 → 1906

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1908 → 1939

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam02172
Location:946 → 1024

KIX; KIX domain

pfam08214
Location:1970 → 2283

HAT_KAT11; Histone acetylation protein
NM_079903.4 → NP_524642.2 nejire, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524642.2

Status: REVIEWED

UniProtKB/TrEMBL

O01368, Q9W321

Related

FBpp0071337

Conserved Domains (7) summary

cd05495
Location:1699 → 1806

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:524 → 594

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:2333 → 2373

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1818 → 1900

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1902 → 1933

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam02172
Location:940 → 1018

KIX; KIX domain

pfam08214
Location:1964 → 2277

HAT_KAT11; Histone acetylation protein