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GOLGA8B golgin A8 family member B [ Homo sapiens (human) ]

Gene ID: 440270, updated on 2-Nov-2024

Summary

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Official Symbol
GOLGA8Bprovided by HGNC
Official Full Name
golgin A8 family member Bprovided by HGNC
Primary source
HGNC:HGNC:31973
See related
Ensembl:ENSG00000215252 MIM:609619; AllianceGenome:HGNC:31973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GOLGA5
Summary
Predicted to be involved in Golgi organization. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 78.1), testis (RPKM 47.6) and 24 other tissues See more
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Genomic context

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See GOLGA8B in Genome Data Viewer
Location:
15q14
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (34525095..34583651, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (32330791..32389340, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34817296..34875852, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene fascin actin-bundling protein 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6287 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6288 Neighboring gene dynamin 1 pseudogene 5 Neighboring gene microRNA 1233-2 Neighboring gene amyloid beta precursor protein binding family A member 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:34861909-34862858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6289 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:34876125-34876626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:34876627-34877127 Neighboring gene MPRA-validated peak2294 silencer Neighboring gene Sharpr-MPRA regulatory region 9988 Neighboring gene uncharacterized LOC124903462 Neighboring gene Sharpr-MPRA regulatory region 12620 Neighboring gene long intergenic non-protein coding RNA 2252

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma. Li Z, et al. Clin Sci (Lond), 2022 Jun 17. PMID 35593117
  2. Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen. Eystathioy T, et al. J Autoimmun, 2000 Mar. PMID 10677249
  3. Identification and characterization of a novel Golgi protein, golgin-67. Jakymiw A, et al. J Biol Chem, 2000 Feb 11. PMID 10660574
  4. A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. Solouki AM, et al. Nat Genet, 2010 Oct. PMID 20835239, Free PMC Article
  5. Analysis of the DNA sequence and duplication history of human chromosome 15. Zody MC, et al. Nature, 2006 Mar 30. PMID 16572171

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma.
    Title: Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0855

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
is_active_in Golgi cis cisterna IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi cisterna membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
golgin subfamily A member 8B
Names
golgi autoantigen, golgin subfamily a, 8B
golgin-67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001023567.5 → NP_001018861.3  golgin subfamily A member 8B

    See identical proteins and their annotated locations for NP_001018861.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
    Source sequence(s)
    AC027139
    Consensus CDS
    CCDS45211.1
    UniProtKB/Swiss-Prot
    A6NLZ2, A8MQT2, Q2M3S9
    UniProtKB/TrEMBL
    B7ZKM1
    Related
    ENSP00000507830.1, ENST00000683415.1
    Conserved Domains (2) summary
    pfam01496
    Location:268 → 322
    V_ATPase_I; V-type ATPase 116kDa subunit family
    pfam15070
    Location:218 → 593
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

RNA

  1. NR_027410.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate upstream promoter and additional 5' exons and retains an intron, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC027139
    Related
    ENST00000569100.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    34525095..34583651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    32330791..32389340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MQT2.2 GenPept UniProtKB/Swiss-Prot:A8MQT2

Gene LinkOut

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Chemical Information
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