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ND-PDSW NADH dehydrogenase (ubiquinone) PDSW subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44228, updated on 26-Jun-2024

Summary

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Official Symbol
ND-PDSWprovided by FlyBase
Official Full Name
NADH dehydrogenase (ubiquinone) PDSW subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0021967
Locus tag
Dmel_CG8844
See related
AllianceGenome:FB:FBgn0021967
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey91; BcDNA:RE65754; CG8844; Dmel\CG8844; dNDUFB10; l(2)k10101; mito; NDUFB10; NIDM; pdsw; Pdsw; PDSW; Q9VQR2
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in several structures, including embryonic Malpighian tubule; endoderm anlage; extended germ band embryo; gut section; and spermatozoon. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 35. Orthologous to human NDUFB10 (NADH:ubiquinone oxidoreductase subunit B10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ND-PDSW in Genome Data Viewer
Location:
23F3-23F3; 2-10 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3466157..3467334)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3466157..3467334)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Secretory 5 Neighboring gene uncharacterized protein Neighboring gene male-specific lethal 2 Neighboring gene mir-4971 stem loop Neighboring gene Pif1 DNA helicase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of mitochondrial organization and function in the Drosophila blastoderm embryo. Chowdhary S, et al. Sci Rep, 2017 Jul 14. PMID 28710464, Free PMC Article
  2. Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila. Ohsawa S, et al. Nature, 2012 Oct 25. PMID 23023132
  3. Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint. Owusu-Ansah E, et al. Nat Genet, 2008 Mar. PMID 18246068
  4. An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Liao TS, et al. Genetics, 2006 Sep. PMID 16849596, Free PMC Article
  5. Genetic Reduction of Mitochondria Complex I Subunits is Protective against Cisplatin-Induced Neurotoxicity in Drosophila. Groen CM, et al. J Neurosci, 2022 Feb 2. PMID 34893548, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NADH dehydrogenase (ubiquinone) PDSW subunit
Names
CG8844-PA
CG8844-PB
NADH ubiquinone oxidoreductase PDSW
NADH-ubiquinone oxidoreductase PDSW subunit
NADH:ubiquinone oxidoreductase PDSW subunit
ND-PDSW-PA
ND-PDSW-PB
pdsw

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3466157..3467334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164537.2 → NP_722908.1  NADH dehydrogenase (ubiquinone) PDSW subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722908.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AQ24, Q9VQR2
    Related
    FBpp0077210
    Conserved Domains (1) summary
    pfam10249
    Location:20 → 145
    NDUFB10; NADH-ubiquinone oxidoreductase subunit 10

  2. NM_143715.3 → NP_651972.1  NADH dehydrogenase (ubiquinone) PDSW subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651972.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AQ24, Q9VQR2
    Related
    FBpp0077209
    Conserved Domains (1) summary
    pfam10249
    Location:20 → 145
    NDUFB10; NADH-ubiquinone oxidoreductase subunit 10
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQR2 Q9VQR2

Gene LinkOut

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