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PRY2 PTPN13 like Y-linked 2 [ Homo sapiens (human) ]

Gene ID: 442862, updated on 26-Oct-2024

Summary

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Official Symbol
PRY2provided by HGNC
Official Full Name
PTPN13 like Y-linked 2provided by HGNC
Primary source
HGNC:HGNC:21504
See related
MIM:400041; AllianceGenome:HGNC:21504
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPN13LY2
Summary
This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more centromeric copy. [provided by RefSeq, Aug 2024]
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Genomic context

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See PRY2 in Genome Data Viewer
Location:
Yq11.223
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (22071706..22084875, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (23337168..23350337)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (24217853..24231022, complement)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene chromodomain Y-linked 12 pseudogene Neighboring gene elongin C pseudogene 15 Neighboring gene uncharacterized LOC102725532 Neighboring gene testis expressed transcript, Y-linked 6B Neighboring gene RNA binding motif protein Y-linked family 1 member F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region. Repping S, et al. Genomics, 2004 Jun. PMID 15177557
  2. Y Chromosome Infertility. Adam MP, et al. , 1993. PMID 20301513
  3. Functional coherence of the human Y chromosome. Lahn BT, et al. Science, 1997 Oct 24. PMID 9381176
  4. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article
  5. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Skaletsky H, et al. Nature, 2003 Jun 19. PMID 12815422

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Spermatogenic failure, Y-linked, 2
MedGen: C1839071 OMIM: 415000 GeneReviews: Y Chromosome Infertility
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • PTPN13-like protein, Y-linked
  • PTPN13-like, Y-linked, centromeric
  • testis-specific PTP-BL-related Y protein
  • testis-specific PTP-BL-related protein on Y

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_197360.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007359

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    22071706..22084875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    23337168..23350337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_032918.1: Suppressed sequence

    Description
    NG_032918.1: This RefSeq was removed by NCBI staff.

  2. NM_001002758.1: Suppressed sequence

    Description
    NM_001002758.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14603.2 GenPept UniProtKB/Swiss-Prot:O14603

Gene LinkOut

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