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suv39h1a SUV39H1 histone lysine methyltransferase a [ Danio rerio (zebrafish) ]

Gene ID: 445198, updated on 9-Dec-2024

Summary

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Official Symbol
suv39h1aprovided by ZNC
Official Full Name
SUV39H1 histone lysine methyltransferase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-111
See related
Ensembl:ENSDARG00000026799 AllianceGenome:ZFIN:ZDB-GENE-040801-111
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fe02c04; suv39h1; wu:fe02c04; zgc:101027
Summary
Enables histone H3K9 methyltransferase activity. Acts upstream of or within chromatin remodeling; exocrine pancreas development; and retina morphogenesis in camera-type eye. Predicted to be located in chromosome, centromeric region. Predicted to be active in nucleus. Is expressed in several structures, including blastomere; digestive system; head; integument; and trunk musculature. Orthologous to human SUV39H1 (SUV39H1 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See suv39h1a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23395506..23405093)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (23374204..23383866)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkey-16n15.3 Neighboring gene si:dkey-16n15.6 Neighboring gene uncharacterized LOC137496345 Neighboring gene G protein-coupled receptor 173 Neighboring gene forkhead box P3b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish. Albacker CE, et al. PLoS One, 2013. PMID 23705022, Free PMC Article
  2. Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development. Rai K, et al. Mol Cell Biol, 2006 Oct. PMID 16980612, Free PMC Article
  3. Codon Usage and 3' UTR Length Determine Maternal mRNA Stability in Zebrafish. Mishima Y, et al. Mol Cell, 2016 Mar 17. PMID 26990990
  4. Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. Brocal I, et al. BMC Genomics, 2016 Mar 24. PMID 27009152, Free PMC Article
  5. Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Despic V, et al. Genome Res, 2017 Jul. PMID 28381614, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables histone H3K9 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K9 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K9 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K9 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K9 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K9me2 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase SUV39H1-A
Names
su(var)3-9 homolog 1-A
suppressor of variegation 3-9 homolog 1
suppressor of variegation 3-9 homolog 1-A
suppressor of variegation 3-9 homolog 1a
suppressor of variegation 3-9-like 1a
NP_001003592.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003592.1 → NP_001003592.1  histone-lysine N-methyltransferase SUV39H1-A

    See identical proteins and their annotated locations for NP_001003592.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076417
    UniProtKB/Swiss-Prot
    A5XBP4, B0S580, Q6DGD3
    Related
    ENSDARP00000034818.6, ENSDART00000038955.7
    Conserved Domains (3) summary
    smart00317
    Location:242 → 365
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam00385
    Location:44 → 91
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
    pfam05033
    Location:139 → 234
    Pre-SET; Pre-SET motif

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    23395506..23405093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DGD3.2 GenPept UniProtKB/Swiss-Prot:Q6DGD3

Gene LinkOut

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