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ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 [ Danio rerio (zebrafish) ]

Gene ID: 445291, updated on 2-Nov-2024

Summary

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Official Symbol
ndufv1provided by ZNC
Official Full Name
NADH:ubiquinone oxidoreductase core subunit V1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040808-73
See related
Ensembl:ENSDARG00000036438 AllianceGenome:ZFIN:ZDB-GENE-040808-73
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:86620; wu:fc01f01; wu:fc12f12
Summary
Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and nucleotide binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Is expressed in several structures, including alar plate midbrain region; immature eye; musculature system; optic tectum; and pronephric duct. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 4. Orthologous to human NDUFV1 (NADH:ubiquinone oxidoreductase core subunit V1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ndufv1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (9212057..9228512)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (9293132..9309587)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:ch211-81a5.8 Neighboring gene hyperpolarization activated cyclic nucleotide-gated potassium channel 3 Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene lysine (K)-specific methyltransferase 2Ba

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Amino acid primed mTOR activity is essential for heart regeneration. Miklas JW, et al. iScience, 2022 Jan 21. PMID 34988408, Free PMC Article
  2. Atp7b deficiency induces zebrafish eye developmental defects. Wu Y, et al. Metallomics, 2023 May 2. PMID 37070960
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Names
NADH dehydrogenase (ubiquinone) flavoprotein 1
NP_001003747.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003747.1 → NP_001003747.1  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

    See identical proteins and their annotated locations for NP_001003747.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078648
    UniProtKB/TrEMBL
    A0A8M1N1T1, Q6AZA2
    Related
    ENSDARP00000052929.5, ENSDART00000052930.6
    Conserved Domains (4) summary
    PRK13596
    Location:66 → 487
    PRK13596; NADH dehydrogenase I subunit F; Provisional
    pfam01512
    Location:111 → 280
    Complex1_51K; Respiratory-chain NADH dehydrogenase 51 Kd subunit
    pfam10531
    Location:306 → 358
    SLBB; SLBB domain
    pfam10589
    Location:397 → 478
    NADH_4Fe-4S; NADH-ubiquinone oxidoreductase-F iron-sulfur binding region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    9212057..9228512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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