nrros negative regulator of reactive oxygen species [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nrrosprovided by ZNC
Official Full Name: negative regulator of reactive oxygen speciesprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040808-36
See related: Ensembl:ENSDARG00000071491 AllianceGenome:ZFIN:ZDB-GENE-040808-36
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lrrc33; zgc:100989
Summary: Predicted to enable receptor ligand inhibitor activity. Predicted to be involved in several processes, including inflammatory response; microglia development; and sequestering of TGFbeta in extracellular matrix. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in extracellular matrix and extracellular space. Is expressed in hematopoietic cell; intermediate cell mass of mesoderm; vein; and ventral mesoderm. Orthologous to human NRROS (negative regulator of reactive oxygen species). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (28410963..28419444, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (28331804..28340285, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables receptor ligand inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in microglia development	ISS Inferred from Sequence or Structural Similarity more info
involved_in sequestering of TGFbeta in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in superoxide metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transforming growth factor beta activator LRRC33

Names: leucine rich repeat containing 33; leucine-rich repeat-containing protein 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003775.2 → NP_001003775.1 transforming growth factor beta activator LRRC33 precursor

See identical proteins and their annotated locations for NP_001003775.1

Status: PROVISIONAL

Source sequence(s)

BC079491

UniProtKB/Swiss-Prot

Q6AXL3

Related

ENSDARP00000096527.3, ENSDART00000105749.5

Conserved Domains (3) summary

cd00116
Location:379 → 584

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:332 → 352

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:378 → 435

LRR_8; Leucine rich repeat