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grb10a growth factor receptor-bound protein 10a [ Danio rerio (zebrafish) ]

Gene ID: 446167, updated on 2-Nov-2024

Summary

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Official Symbol
grb10aprovided by ZNC
Official Full Name
growth factor receptor-bound protein 10aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040822-32
See related
Ensembl:ENSDARG00000002013 AllianceGenome:ZFIN:ZDB-GENE-040822-32
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
grb10; zgc:91987
Summary
Predicted to enable insulin receptor binding activity. Predicted to be involved in insulin receptor signaling pathway; negative regulation of Wnt signaling pathway; and negative regulation of insulin receptor signaling pathway. Predicted to act upstream of or within signal transduction. Orthologous to human GRB10 (growth factor receptor bound protein 10). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See grb10a in Genome Data Viewer
Location:
chromosome: 19
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (23133390..23249839, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (23549067..23665523, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene Ig kappa-b4 chain C region-like Neighboring gene transfer RNA proline (anticodon AGG) Neighboring gene si:dkey-79i2.4 Neighboring gene immunity-related GTPase family, f1 Neighboring gene uncharacterized LOC137488438

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Early leucine programming on protein utilization and mTOR signaling by DNA methylation in zebrafish (Danio rerio). Zhu QS, et al. Nutr Metab (Lond), 2020. PMID 32818036, Free PMC Article
  2. Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Anelli V, et al. Zebrafish, 2009 Dec. PMID 20047469
  3. Ewing sarcoma ewsa protein regulates chondrogenesis of Meckel's cartilage through modulation of Sox9 in zebrafish. Merkes C, et al. PLoS One, 2015. PMID 25617839, Free PMC Article
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
growth factor receptor-bound protein 10a
Names
growth factor receptor-bound protein 10
zgc:91987growth factor receptor-bound protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004287.2 → NP_001004287.1  growth factor receptor-bound protein 10a

    See identical proteins and their annotated locations for NP_001004287.1

    Status: VALIDATED

    Source sequence(s)
    BX571825, EH449392
    UniProtKB/TrEMBL
    A0A8N7XJL9, B2GTE0, F6NNM8, Q68EG5
    Related
    ENSDARP00000115883.1, ENSDART00000140665.3
    Conserved Domains (5) summary
    cd10415
    Location:495 → 602
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:295 → 417
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:300 → 407
    PH; PH domain
    pfam08947
    Location:434 → 474
    BPS; BPS (Between PH and SH2)
    cl00155
    Location:175 → 255
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    23133390..23249839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215118.1 → XP_068071219.1  growth factor receptor-bound protein 10a isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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