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MSMB microseminoprotein beta [ Homo sapiens (human) ]

Gene ID: 4477, updated on 17-Jun-2024

Summary

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Official Symbol
MSMBprovided by HGNC
Official Full Name
microseminoprotein betaprovided by HGNC
Primary source
HGNC:HGNC:7372
See related
Ensembl:ENSG00000263639 MIM:157145; AllianceGenome:HGNC:7372
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSP; PSP; IGBF; MSPB; PN44; PRPS; HPC13; PSP57; PSP94; PSP-94
Summary
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward prostate (RPKM 2642.5) See more
Orthologs
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Genomic context

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See MSMB in Genome Data Viewer
Location:
10q11.22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (46033313..46046269, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (46914187..46927144, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (51549553..51562509)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene small nucleolar RNA, H/ACA box 74C-1 Neighboring gene NANOG hESC enhancer GRCh37_chr10:51396871-51397413 Neighboring gene Sharpr-MPRA regulatory region 10440 Neighboring gene nuclear receptor coactivator 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:51574030-51574225 Neighboring gene Sharpr-MPRA regulatory region 5969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2350 Neighboring gene uncharacterized LOC105378287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3324 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:51551103-51551604 Neighboring gene Sharpr-MPRA regulatory region 2638 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:51541582-51542406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:51528729-51529229 Neighboring gene ribosomal protein L23a pseudogene 61 Neighboring gene Sharpr-MPRA regulatory region 10026 Neighboring gene Sharpr-MPRA regulatory regions 2667 and 7132 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 7, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing. Wang X, et al. Gene, 2021 Feb 5. PMID 33122083, Free PMC Article
  2. A meta-analysis of influence of MSMB promoter rs10993994 polymorphisms on prostate cancer risk. Fu S, et al. Eur Rev Med Pharmacol Sci, 2019 Nov. PMID 31773691
  3. The role of plasma microseminoprotein-beta in prostate cancer: an observational nested case-control and Mendelian randomization study in the European prospective investigation into cancer and nutrition. Smith Byrne K, et al. Ann Oncol, 2019 Jun 1. PMID 31089709, Free PMC Article
  4. Structural and molecular biology of PSP94: Its significance in prostate pathophysiology. Anklesaria JH, et al. Front Biosci (Landmark Ed), 2018 Jan 1. PMID 28930560
  5. MSMB gene rs10993994 polymorphism increases the risk of prostate cancer. Peng T, et al. Oncotarget, 2017 Apr 25. PMID 28212531, Free PMC Article

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing.
    Title: Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing.
  2. A meta-analysis of influence of MSMB promoter rs10993994 polymorphisms on prostate cancer risk.
    Title: A meta-analysis of influence of MSMB promoter rs10993994 polymorphisms on prostate cancer risk.
  3. Low plasma microseminoprotein-beta levels are associated with prostate cancer.
    Title: The role of plasma microseminoprotein-beta in prostate cancer: an observational nested case-control and Mendelian randomization study in the European prospective investigation into cancer and nutrition.
  4. Aggressive prostate tumors suppress MSMB synthesis in the benign prostate and this could explain why serum levels of MSMB are decreased in prostate cancer patients.
    Title: Prostate tumors downregulate microseminoprotein-beta (MSMB) in the surrounding benign prostate epithelium and this response is associated with tumor aggressiveness.
  5. Studies indicate prostate secretory protein of 94 amino acids (PSP94) as a prostate tumor marker [Review].
    Title: Structural and molecular biology of PSP94: Its significance in prostate pathophysiology.
  6. this meta-analysis indicates that MSMB gene rs10993994 polymorphism increases the risk of PC.
    Title: MSMB gene rs10993994 polymorphism increases the risk of prostate cancer.
  7. PSP94 levels differed among idiopathic pulmonary fibrosis, pulmonary sarcoidosis and chronic pulmonary obstructive disease.
    Title: Prognostic significance of surfactant protein A, surfactant protein D, Clara cell protein 16, S100 protein, trefoil factor 3, and prostatic secretory protein 94 in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease.
  8. Results identified CRISP2 as a potential binding protein of PSP94 from human sperm.
    Title: Identification of CRISP2 from human sperm as PSP94-binding protein and generation of CRISP2-specific anti-peptide antibodies.
  9. decreased expression of MSMB parallels the clinical progression of PC and adjusted serum MSMB levels are associated with PC risk
    Title: Microseminoprotein-Beta Expression in Different Stages of Prostate Cancer.
  10. Based on nasopharyngeal MSP gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants.
    Title: Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection.
Submit: New GeneRIF Correction See all GeneRIFs (54)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Prostate cancer, hereditary, 13
MedGen: C2677821 OMIM: 611928 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genetic correction of PSA values using sequence variants associated with PSA levels.
EBI GWAS Catalog
Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies.
EBI GWAS Catalog
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
EBI GWAS Catalog
Genome-wide association scan for variants associated with early-onset prostate cancer.
EBI GWAS Catalog
Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
EBI GWAS Catalog
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
EBI GWAS Catalog
Genome-wide association study identifies genetic determinants of urine PCA3 levels in men.
EBI GWAS Catalog
Genome-wide association study identifies new prostate cancer susceptibility loci.
EBI GWAS Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog
Multiple loci identified in a genome-wide association study of prostate cancer.
EBI GWAS Catalog
Multiple newly identified loci associated with prostate cancer susceptibility.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: NCOA4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular space TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
beta-microseminoprotein
Names
immunoglobulin binding factor
prostate secreted seminal plasma protein
prostate secretory protein of 94 amino acids
seminal plasma beta-inhibin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011551.1 RefSeqGene

    Range
    5001..17957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002443.4 → NP_002434.1  beta-microseminoprotein isoform a precursor

    See identical proteins and their annotated locations for NP_002434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (PSP94) encodes the full length isoform (a).
    Source sequence(s)
    BC005257, BM856408
    Consensus CDS
    CCDS73096.1
    UniProtKB/Swiss-Prot
    B1API6, P08118, P11999, Q13125, Q6IAY9, Q9UC59
    UniProtKB/TrEMBL
    B2R597
    Related
    ENSP00000463092.1, ENST00000582163.3
    Conserved Domains (1) summary
    pfam05825
    Location:21 → 114
    PSP94; Beta-microseminoprotein (PSP-94)

  2. NM_138634.3 → NP_619540.1  beta-microseminoprotein isoform b precursor

    See identical proteins and their annotated locations for NP_619540.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (PSP57) lacks an alternate coding exon compared to variant PSP94, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    BF680662
    Consensus CDS
    CCDS73095.1
    UniProtKB/Swiss-Prot
    P08118
    Related
    ENSP00000462641.1, ENST00000581478.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    46033313..46046269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    46914187..46927144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08118.1 GenPept UniProtKB/Swiss-Prot:P08118

Gene LinkOut

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