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dlgap5 discs, large (Drosophila) homolog-associated protein 5 [ Danio rerio (zebrafish) ]

Gene ID: 447853, updated on 2-Nov-2024

Summary

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Official Symbol
dlgap5provided by ZNC
Official Full Name
discs, large (Drosophila) homolog-associated protein 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-040912-160
See related
Ensembl:ENSDARG00000045167 AllianceGenome:ZFIN:ZDB-GENE-040912-160
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dlg7; cb647; sb:cb647; zgc:92146; wu:fc96g08; wu:fe11c02
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Predicted to act upstream of or within signaling. Predicted to be active in cytoplasm; nucleus; and spindle pole centrosome. Is expressed in brain; head; otic vesicle; pectoral fin musculature; and proliferative region. Orthologous to human DLGAP5 (DLG associated protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dlgap5 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (17633508..17655668, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (17511480..17533804, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 42 Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 1 Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene radial spoke head 10 homolog B Neighboring gene CCZ1 homolog, vacuolar protein trafficking and biogenesis associated Neighboring gene parvalbumin 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish. Qin Z, et al. Proc Natl Acad Sci U S A, 2009 Jun 9. PMID 19474300, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in centrosome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
disks large-associated protein 5
Names
discs, large homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004592.1 → NP_001004592.1  disks large-associated protein 5

    See identical proteins and their annotated locations for NP_001004592.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081607
    UniProtKB/TrEMBL
    Q66HZ9
    Related
    ENSDARP00000066410.5, ENSDART00000066411.7
    Conserved Domains (1) summary
    pfam03359
    Location:360 → 505
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    17633508..17655668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169455.5 → XP_005169512.1  disks large-associated protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BGU9
    Conserved Domains (1) summary
    pfam03359
    Location:360 → 505
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394834.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    77639..100424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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