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mylpfb myosin light chain, phosphorylatable, fast skeletal muscle b [ Danio rerio (zebrafish) ]

Gene ID: 447930, updated on 12-May-2024

Summary

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Official Symbol
mylpfbprovided by ZNC
Official Full Name
myosin light chain, phosphorylatable, fast skeletal muscle bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040912-115
See related
Ensembl:ENSDARG00000002589 AllianceGenome:ZFIN:ZDB-GENE-040912-115
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:103639
Summary
Predicted to enable calcium ion binding activity. Is expressed in mesoderm; musculature system; and somite. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C. Orthologous to human MYLPF (myosin light chain, phosphorylatable, fast skeletal muscle). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See mylpfb in Genome Data Viewer
Location:
chromosome: 12
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (15008632..15010996)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (14970329..14972693)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene neuronal differentiation 2 Neighboring gene protein kinase, membrane associated tyrosine/threonine 1 Neighboring gene phenylethanolamine N-methyltransferase Neighboring gene uncharacterized LOC101882309

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Auxotonic to isometric contraction transitioning in a beating heart causes myosin step-size to down shift. Burghardt TP, et al. PLoS One, 2017. PMID 28423017, Free PMC Article
  2. Mutations in MYLPF Cause a Novel Segmental Amyoplasia that Manifests as Distal Arthrogryposis. Chong JX, et al. Am J Hum Genet, 2020 Aug 6. PMID 32707087, Free PMC Article
  3. In vivo myosin step-size from zebrafish skeletal muscle. Burghardt TP, et al. Open Biol, 2016 May. PMID 27249818, Free PMC Article
  4. Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms. Chen Z, et al. Cardiovasc Res, 2008 Jul 1. PMID 18343897, Free PMC Article
  5. First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos. Kwon OK, et al. Sci Rep, 2018 Feb 26. PMID 29483630, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin-myosin filament sliding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in muscle tissue morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in skeletal muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin regulatory light chain 2, skeletal muscle isoform B
Names
myosin regulatory light chain 2, skeletal muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004668.1 → NP_001004668.1  myosin regulatory light chain 2, skeletal muscle isoform B

    See identical proteins and their annotated locations for NP_001004668.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081501
    UniProtKB/Swiss-Prot
    Q66I73
    Related
    ENSDARP00000023063.8, ENSDART00000003847.9
    Conserved Domains (1) summary
    COG5126
    Location:16 → 165
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    15008632..15010996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66I73.1 GenPept UniProtKB/Swiss-Prot:Q66I73

Gene LinkOut

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