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zgc:103482 zgc:103482 [ Danio rerio (zebrafish) ]

Gene ID: 450001, updated on 2-Nov-2024

Summary

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Official Symbol
zgc:103482provided by ZNC
Official Full Name
zgc:103482provided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-115
See related
Ensembl:ENSDARG00000025174 AllianceGenome:ZFIN:ZDB-GENE-041010-115
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
habp4
Summary
Enables ribosome binding activity and translation elongation factor binding activity. Involved in ribosome hibernation. Predicted to be located in cytoplasmic stress granule and nuclear lumen. Predicted to be active in cytoplasm and nucleus. Is expressed in primordial germ cell. Orthologous to human HABP4 (hyaluronan binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See zgc:103482 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (20396891..20402684)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (20360222..20366050)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene si:dkey-30k6.5 Neighboring gene heat shock protein, alpha-crystallin-related, b9-like Neighboring gene ephrin-A5a Neighboring gene growth arrest and DNA damage-inducible protein GADD45 gamma-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A molecular network of conserved factors keeps ribosomes dormant in the egg. Leesch F, et al. Nature, 2023 Jan. PMID 36653451, Free PMC Article
  2. A Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells. Zhang R, et al. Adv Sci (Weinh), 2022 Dec. PMID 36257818, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation elongation factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome hibernation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
intracellular hyaluronan-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006022.1 → NP_001006022.1  intracellular hyaluronan-binding protein 4

    See identical proteins and their annotated locations for NP_001006022.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083399
    UniProtKB/Swiss-Prot
    B0R085, Q5XJA5
    Related
    ENSDARP00000007173.7, ENSDART00000003299.9
    Conserved Domains (2) summary
    pfam04774
    Location:152 → 253
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    pfam16174
    Location:11 → 96
    IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    20396891..20402684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161172.5 → XP_005161229.1  intracellular hyaluronan-binding protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B0R085, Q5XJA5
    UniProtKB/TrEMBL
    A0A8M2B834
    Conserved Domains (2) summary
    pfam04774
    Location:152 → 254
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    pfam16174
    Location:11 → 96
    IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XJA5.2 GenPept UniProtKB/Swiss-Prot:Q5XJA5

Gene LinkOut

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