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lrrc23 leucine rich repeat containing 23 [ Danio rerio (zebrafish) ]

Gene ID: 450033, updated on 27-Dec-2024

Summary

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Official Symbol
lrrc23provided by ZNC
Official Full Name
leucine rich repeat containing 23provided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-153
See related
Ensembl:ENSDARG00000006174 AllianceGenome:ZFIN:ZDB-GENE-041010-153
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:101782
Summary
Acts upstream of or within cilium movement involved in otolith formation. Predicted to be active in cytoplasm. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; nervous system; pronephric duct; and spinal cord neural keel. Human ortholog(s) of this gene implicated in spermatogenic failure 92. Orthologous to human LRRC23 (leucine rich repeat containing 23). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See lrrc23 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (20127883..20134012, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (20201540..20207639, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene troponin C type 1b (slow) Neighboring gene transketolase b Neighboring gene si:dkey-32e6.3 Neighboring gene ubiquitin specific peptidase 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Radial spoke proteins regulate otolith formation during early zebrafish development. Han X, et al. FASEB J, 2018 Jul. PMID 29475374
  2. Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. Austin-Tse C, et al. Am J Hum Genet, 2013 Oct 3. PMID 24094744, Free PMC Article
  3. Rbm24a Is Necessary for Hair Cell Development Through Regulating mRNA Stability in Zebrafish. Zhang Y, et al. Front Cell Dev Biol, 2020. PMID 33392193, Free PMC Article
  4. RNA-sequencing analysis of TCDD-induced responses in zebrafish liver reveals high relatedness to in vivo mammalian models and conserved biological pathways. Li ZH, et al. PLoS One, 2013. PMID 24204792, Free PMC Article
  5. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in lrrc23 resulted in a selective otolith formation defect during early ear development.
    Title: Radial spoke proteins regulate otolith formation during early zebrafish development.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cilium movement involved in otolith formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006054.1 → NP_001006054.1  leucine-rich repeat-containing protein 23

    See identical proteins and their annotated locations for NP_001006054.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083278
    UniProtKB/TrEMBL
    Q5XJM1
    Related
    ENSDARP00000004624.4, ENSDART00000004871.7
    Conserved Domains (3) summary
    sd00033
    Location:64 → 83
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:194 → 235
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:194 → 251
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    20127883..20134012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068216742.1 → XP_068072843.1  leucine-rich repeat-containing protein 23 isoform X1

Nucleotide Protein
Heading Accession and Version

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