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tpk1 thiamin pyrophosphokinase 1 [ Danio rerio (zebrafish) ]

Gene ID: 450054, updated on 4-Jan-2025

Summary

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Official Symbol
tpk1provided by ZNC
Official Full Name
thiamin pyrophosphokinase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-176
See related
Ensembl:ENSDARG00000038040 AllianceGenome:ZFIN:ZDB-GENE-041010-176
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:101685
Summary
Predicted to enable thiamine diphosphokinase activity. Predicted to be involved in thiamine diphosphate biosynthetic process. Predicted to act upstream of or within phosphorylation and thiamine metabolic process. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human TPK1 (thiamin pyrophosphokinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See tpk1 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (18286427..18444729)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (18142008..18300314)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene contactin associated protein 2a Neighboring gene uncharacterized LOC137489233 Neighboring gene uncharacterized LOC137489287 Neighboring gene si:dkey-73n8.3 Neighboring gene zgc:112332 Neighboring gene SEC61 translocon subunit gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables thiamine binding IEA
Inferred from Electronic Annotation
more info
  
enables thiamine diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiamine diphosphokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within thiamine diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within thiamine metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thiamine pyrophosphokinase 1
NP_001006074.1
XP_005162672.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006074.1 → NP_001006074.1  thiamine pyrophosphokinase 1

    See identical proteins and their annotated locations for NP_001006074.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083247
    UniProtKB/TrEMBL
    Q5XJQ1
    Related
    ENSDARP00000055442.5, ENSDART00000055443.7
    Conserved Domains (2) summary
    cd07995
    Location:19 → 243
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:20 → 247
    PLN02714; thiamin pyrophosphokinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    18286427..18444729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162615.5 → XP_005162672.1  thiamine pyrophosphokinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B9G6, F1RBJ9
    Conserved Domains (2) summary
    cd07995
    Location:19 → 243
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:20 → 247
    PLN02714; thiamin pyrophosphokinase

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395169.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    26024..127082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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