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osr1 odd-skipped related transcription factor 1 [ Danio rerio (zebrafish) ]

Gene ID: 450059, updated on 17-Nov-2024

Summary

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Official Symbol
osr1provided by ZNC
Official Full Name
odd-skipped related transcription factor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-070321-1
See related
Ensembl:ENSDARG00000014091 AllianceGenome:ZFIN:ZDB-GENE-070321-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:101674
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in angioblast cell differentiation; negative regulation of transcription by RNA polymerase II; and pronephric nephron development. Acts upstream of or within several processes, including kidney development; pectoral fin development; and regulation of nodal signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including endoderm; germ ring; head; mesoderm; and vasculature. Orthologous to human OSR1 (odd-skipped related transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See osr1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (32144370..32150443)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (32013920..32019993)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487417 Neighboring gene uncharacterized LOC137487419 Neighboring gene uncharacterized LOC137487418 Neighboring gene uncharacterized LOC137487420 Neighboring gene 5'-nucleotidase, cytosolic IB a Neighboring gene retinol dehydrogenase 14a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The genetic factors of bilaterian evolution. Heger P, et al. Elife, 2020 Jul 16. PMID 32672535, Free PMC Article
  2. odd skipped-related 2 as a novel mark for labeling the proximal convoluted tubule within the zebrafish kidney. Yang W, et al. Heliyon, 2024 Mar 30. PMID 38496848, Free PMC Article
  3. osr1 is required for podocyte development downstream of wt1a. Tomar R, et al. J Am Soc Nephrol, 2014 Nov. PMID 24722440, Free PMC Article
  4. The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development. Neto A, et al. Development, 2012 Jan. PMID 22129829
  5. Odd skipped related 1 is a negative feedback regulator of nodal-induced endoderm development. Terashima AV, et al. Dev Dyn, 2014 Dec. PMID 25233796, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hand2 and the co-expressed zinc-finger transcription factor osr1 have functionally antagonistic influences on kidney development. Together, our data suggest that hand2 functions in opposition to osr1 to balance the formation of kidney and vein progenitors by regulating cell fate decisions at the lateral boundary of the Iintermediate mesoderm
    Title: Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm.
  2. findings identify osr1 as a Nodal-induced, negative feedback regulator of Nodal signaling that acts at the earliest stages of endoderm differentiation to limit the number of endoderm progenitors.
    Title: Odd skipped related 1 is a negative feedback regulator of nodal-induced endoderm development.
  3. Our results place osr1 in a framework of transcriptional regulators that control the expression of podocin and nephrin and thereby mediate podocyte differentiation.
    Title: osr1 is required for podocyte development downstream of wt1a.
  4. The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development.
    Title: The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development.
  5. Odd genes may also be required for proper development of the Malpighian tubules, the Drosophila renal organs
    Title: Odd-skipped genes encode repressors that control kidney development.
  6. osr1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate.
    Title: odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in angioblast cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intermediate mesoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesendoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pectoral fin development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pectoral fin development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within podocyte development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within podocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within podocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pronephric distal tubule development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pronephric glomerulus morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pronephric glomerulus morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pronephric nephron tubule epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pronephric proximal tubule development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pronephric proximal tubule development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pronephros development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pronephros development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within pronephros development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of endodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of nodal signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in urogenital system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein odd-skipped-related 1
Names
MGC:101674
odd-skipped related 1
odd-skipped related transciption factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006079.1 → NP_001006079.1  protein odd-skipped-related 1

    See identical proteins and their annotated locations for NP_001006079.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083241
    UniProtKB/Swiss-Prot
    Q5XJQ7
    UniProtKB/TrEMBL
    B2GQ48
    Related
    ENSDARP00000023564.5, ENSDART00000020270.7
    Conserved Domains (3) summary
    sd00017
    Location:176 → 196
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:174 → 196
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:188 → 213
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    32144370..32150443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XJQ7.1 GenPept UniProtKB/Swiss-Prot:Q5XJQ7

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