asah1a N-acylsphingosine amidohydrolase (acid ceramidase) 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: asah1aprovided by ZNC
Official Full Name: N-acylsphingosine amidohydrolase (acid ceramidase) 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-191
See related: Ensembl:ENSDARG00000037091 AllianceGenome:ZFIN:ZDB-GENE-041010-191
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: asah1; zgc:101637
Summary: Predicted to enable N-acylsphingosine amidohydrolase activity. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in Farber lipogranulomatosis; sphingolipidosis; and spinal muscular atrophy with progressive myoclonic epilepsy. Orthologous to human ASAH1 (N-acylsphingosine amidohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (30272848..30277973)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (29932538..29937659)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N-acylsphingosine amidohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acylsphingosine amidohydrolase activity	IEA Inferred from Electronic Annotation more info
enables ceramidase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid amide hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acylsphingosine amidohydrolase (acid ceramidase) 1a; N-acylsphingosine amidohydrolase 1

Names: N-acylsphingosine amidohydrolase (acid ceramidase) 1

NP_001006088.1

EC 3.5.1.23

XP_009289386.1

EC 3.5.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006088.1 → NP_001006088.1 N-acylsphingosine amidohydrolase (acid ceramidase) 1a precursor

See identical proteins and their annotated locations for NP_001006088.1

Status: PROVISIONAL

Source sequence(s)

BC083231

UniProtKB/TrEMBL

Q5XJR7

Related

ENSDARP00000007893.6, ENSDART00000017122.8

Conserved Domains (2) summary

cd01903
Location:129 → 374

Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...

pfam15508
Location:41 → 134

NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

30272848..30277973

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009291111.3 → XP_009289386.1 N-acylsphingosine amidohydrolase 1 isoform X1

UniProtKB/TrEMBL

A0A8M3AS22

Conserved Domains (2) summary

pfam15508
Location:41 → 134

NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase

cl00467
Location:129 → 229

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...