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baz2a bromodomain adjacent to zinc finger domain, 2A [ Danio rerio (zebrafish) ]

Gene ID: 450079, updated on 2-Nov-2024

Summary

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Official Symbol
baz2aprovided by ZNC
Official Full Name
bromodomain adjacent to zinc finger domain, 2Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-202
See related
Ensembl:ENSDARG00000102974 AllianceGenome:ZFIN:ZDB-GENE-041010-202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:101601
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in rDNA heterochromatin. Orthologous to human BAZ2A (bromodomain adjacent to zinc finger domain 2A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See baz2a in Genome Data Viewer
Location:
chromosome: 23
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (6673299..6727718, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (6739327..6793746, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene aquaporin-4 Neighboring gene major intrinsic protein of lens fiber b Neighboring gene prostaglandin E synthase 3b (cytosolic) Neighboring gene secreted frizzled-related protein 5 Neighboring gene prolyl 4-hydroxylase, transmembrane a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
  2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  3. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bromodomain adjacent to zinc finger domain protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320131.1 → NP_001307060.1  bromodomain adjacent to zinc finger domain protein 2A

    Status: VALIDATED

    Source sequence(s)
    CR450824, FP102118, FP102169
    UniProtKB/TrEMBL
    A0A0R4IVN8, A0A8M1P2D8
    Conserved Domains (6) summary
    cd05503
    Location:2355 → 2451
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    cd01397
    Location:1049 → 1123
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:2235 → 2281
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15613
    Location:1971 → 2004
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl02674
    Location:1389 → 1451
    DDT; DDT domain
    cl26464
    Location:298 → 629
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    6673299..6727718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021469791.2 → XP_021325466.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

    UniProtKB/TrEMBL
    A0A0R4IVN8, A0A8M1P2D8
    Related
    ENSDARP00000139219.1, ENSDART00000157828.2
    Conserved Domains (6) summary
    cd05503
    Location:2355 → 2451
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    cd01397
    Location:1049 → 1123
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:2235 → 2281
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15613
    Location:1971 → 2004
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl02674
    Location:1389 → 1451
    DDT; DDT domain
    cl26464
    Location:298 → 629
    Atrophin-1; Atrophin-1 family

  2. XM_068216743.1 → XP_068072844.1  bromodomain adjacent to zinc finger domain protein 2A isoform X3

  3. XM_021469792.2 → XP_021325467.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    UniProtKB/TrEMBL
    A0A8M9P535
    Conserved Domains (6) summary
    cd05503
    Location:2333 → 2429
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    cd01397
    Location:1049 → 1123
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:2213 → 2259
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15613
    Location:1971 → 2004
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl02674
    Location:1389 → 1451
    DDT; DDT domain
    cl26464
    Location:298 → 629
    Atrophin-1; Atrophin-1 family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006099.1: Suppressed sequence

    Description
    NM_001006099.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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