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TRIM37 tripartite motif containing 37 [ Homo sapiens (human) ]

Gene ID: 4591, updated on 2-Nov-2024

Summary

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Official Symbol
TRIM37provided by HGNC
Official Full Name
tripartite motif containing 37provided by HGNC
Primary source
HGNC:HGNC:7523
See related
Ensembl:ENSG00000108395 MIM:605073; AllianceGenome:HGNC:7523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MUL; POB1; TEF3
Summary
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020]
Expression
Broad expression in testis (RPKM 19.8), brain (RPKM 14.1) and 23 other tissues See more
Orthologs
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Genomic context

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See TRIM37 in Genome Data Viewer
Location:
17q22
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (58967201..59106880, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (59835276..59974976, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (57060010..57184241, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1E Neighboring gene RNA, U6 small nuclear 518, pseudogene Neighboring gene ribosomal protein S12 pseudogene 30 Neighboring gene MPRA-validated peak2922 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:57078614-57079813 Neighboring gene RNA, 7SL, cytoplasmic 716, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:57183329-57183988 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:57183989-57184648 Neighboring gene uncharacterized LOC124904039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12500 Neighboring gene RNA, U2 small nuclear 58, pseudogene Neighboring gene spindle and kinetochore associated complex subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Refractory congestive heart failure following delayed pericardectomy in a 12-year-old child with Mulibrey nanism due to a novel mutation in TRIM37. Kumpf M, et al. Eur J Pediatr, 2013 Oct. PMID 23385855
  2. Oncogenic TRIM37 Links Chemoresistance and Metastatic Fate in Triple-Negative Breast Cancer. Przanowski P, et al. Cancer Res, 2020 Nov 1. PMID 32855208, Free PMC Article
  3. TRIM37 is highly expressed during mitosis in CHON-002 chondrocytes cell line and is regulated by miR-223. Brigant B, et al. Bone, 2020 Aug. PMID 32353567
  4. Ginkgolide B protects human pulmonary alveolar epithelial A549 cells from lipopolysaccharide-induced inflammatory responses by reducing TRIM37-mediated NF-κB activation. Xiang Y, et al. Biotechnol Appl Biochem, 2020 Nov. PMID 31691373
  5. Knockdown of TRIM37 suppresses the proliferation, migration and invasion of glioma cells through the inactivation of PI3K/Akt signaling pathway. Tang SL, et al. Biomed Pharmacother, 2018 Mar. PMID 29324313

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and regulate stemness in glioma stem cells through sonic hedgehog pathway.
    Title: TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and regulate stemness in glioma stem cells through sonic hedgehog pathway.
  2. TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1.
    Title: TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1.
  3. TRIM37 Augments AP-2gamma Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression.
    Title: TRIM37 Augments AP-2γ Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression.
  4. Liver pathology and biochemistry in patients with mutations in TRIM37 gene (Mulibrey nanism).
    Title: Liver pathology and biochemistry in patients with mutations in TRIM37 gene (Mulibrey nanism).
  5. TRIM37 Promotes Pancreatic Cancer Progression through Modulation of Cell Growth, Migration, Invasion, and Tumor Immune Microenvironment.
    Title: TRIM37 Promotes Pancreatic Cancer Progression through Modulation of Cell Growth, Migration, Invasion, and Tumor Immune Microenvironment.
  6. TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin.
    Title: TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin.
  7. Circular RNA circRNA_101996 promoted cervical cancer development by regulating miR-1236-3p/TRIM37 axis.
    Title: Circular RNA circRNA_101996 promoted cervical cancer development by regulating miR-1236-3p/TRIM37 axis.
  8. TRIM37 orchestrates renal cell carcinoma progression via histone H2A ubiquitination-dependent manner.
    Title: TRIM37 orchestrates renal cell carcinoma progression via histone H2A ubiquitination-dependent manner.
  9. ASB16-AS1 up-regulated and phosphorylated TRIM37 to activate NF-kappaB pathway and promote proliferation, stemness, and cisplatin resistance of gastric cancer.
    Title: ASB16-AS1 up-regulated and phosphorylated TRIM37 to activate NF-κB pathway and promote proliferation, stemness, and cisplatin resistance of gastric cancer.
  10. TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity.
    Title: TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Mulibrey nanism syndrome
MedGen: C0524582 OMIM: 253250 GeneReviews: Not available
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EBI GWAS Catalog

Description
Meta-analysis identifies four new loci associated with testicular germ cell tumor.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0898

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AK119 ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tumor necrosis factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tumor necrosis factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aggresome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aggresome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of protein import into peroxisome matrix IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein monoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in aggresome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in aggresome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM37
Names
RING-B-box-coiled-coil protein
RING-type E3 ubiquitin transferase TRIM37
mulibrey nanism protein
NP_001005207.1
NP_001307916.1
NP_001307917.1
NP_001307918.1
NP_001307919.1
NP_001340011.1
NP_001340012.1
NP_001340013.1
NP_001340014.1
NP_001340015.1
NP_056109.1
XP_005257442.1
XP_011523133.1
XP_011523134.1
XP_011523135.1
XP_011523136.1
XP_011523138.1
XP_016880151.1
XP_016880152.1
XP_016880154.1
XP_016880156.1
XP_016880158.1
XP_016880159.1
XP_016880162.1
XP_047292062.1
XP_047292063.1
XP_047292064.1
XP_047292065.1
XP_047292066.1
XP_047292067.1
XP_047292068.1
XP_047292069.1
XP_047292070.1
XP_047292071.1
XP_047292072.1
XP_047292073.1
XP_047292074.1
XP_047292075.1
XP_047292076.1
XP_047292077.1
XP_047292078.1
XP_047292079.1
XP_047292080.1
XP_047292081.1
XP_047292082.1
XP_054172173.1
XP_054172174.1
XP_054172175.1
XP_054172176.1
XP_054172177.1
XP_054172178.1
XP_054172179.1
XP_054172180.1
XP_054172181.1
XP_054172182.1
XP_054172183.1
XP_054172184.1
XP_054172185.1
XP_054172186.1
XP_054172187.1
XP_054172188.1
XP_054172189.1
XP_054172190.1
XP_054172191.1
XP_054172192.1
XP_054172193.1
XP_054172194.1
XP_054172195.1
XP_054172196.1
XP_054172197.1
XP_054172198.1
XP_054172199.1
XP_054172200.1
XP_054172201.1
XP_054172202.1
XP_054172203.1
XP_054172204.1
XP_054172205.1
XP_054172206.1
XP_054172207.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009298.2 RefSeqGene

    Range
    5000..113678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001005207.5 → NP_001005207.1  E3 ubiquitin-protein ligase TRIM37 isoform a

    See identical proteins and their annotated locations for NP_001005207.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) and variant 1 encode the same isoform (a).
    Source sequence(s)
    AI307801, AK292459, BC036012, DC351295
    Consensus CDS
    CCDS45746.1
    UniProtKB/Swiss-Prot
    A8K0V9, A8K8U4, A8MZ79, B4DGZ3, F8WEE6, O94972, Q7Z3E6, Q8IYF7, Q8WYF7
    Related
    ENSP00000376785.3, ENST00000393066.7
    Conserved Domains (4) summary
    smart00502
    Location:132 → 254
    BBC; B-Box C-terminal domain
    cd00162
    Location:15 → 58
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273 → 406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90 → 132
    zf-B_box; B-box zinc finger

  2. NM_001320987.3 → NP_001307916.1  E3 ubiquitin-protein ligase TRIM37 isoform b

    Status: REVIEWED

    Source sequence(s)
    AB020705, AC099850, AC100832, AI610736, AK294850, DC343932
    Consensus CDS
    CCDS82174.1
    UniProtKB/Swiss-Prot
    O94972
    Related
    ENSP00000376784.2, ENST00000393065.6
    Conserved Domains (3) summary
    smart00502
    Location:98 → 220
    BBC; B-Box C-terminal domain
    cd03773
    Location:239 → 372
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:56 → 98
    zf-B_box; B-box zinc finger

  3. NM_001320988.3 → NP_001307917.1  E3 ubiquitin-protein ligase TRIM37 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) and variant 5 encode the same isoform (c).
    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (4) summary
    smart00502
    Location:132 → 254
    BBC; B-Box C-terminal domain
    cd00162
    Location:15 → 58
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273 → 406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90 → 132
    zf-B_box; B-box zinc finger

  4. NM_001320989.3 → NP_001307918.1  E3 ubiquitin-protein ligase TRIM37 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) and variant 4 encode the same isoform (c).
    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (4) summary
    smart00502
    Location:132 → 254
    BBC; B-Box C-terminal domain
    cd00162
    Location:15 → 58
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273 → 406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90 → 132
    zf-B_box; B-box zinc finger

  5. NM_001320990.3 → NP_001307919.1  E3 ubiquitin-protein ligase TRIM37 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC100832, BX537955, DC343932
    UniProtKB/Swiss-Prot
    O94972
    Conserved Domains (2) summary
    smart00502
    Location:10 → 132
    BBC; B-Box C-terminal domain
    cd03773
    Location:151 → 284
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

  6. NM_001353082.2 → NP_001340011.1  E3 ubiquitin-protein ligase TRIM37 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (4) summary
    smart00502
    Location:98 → 220
    BBC; B-Box C-terminal domain
    smart00336
    Location:57 → 98
    BBOX; B-Box-type zinc finger
    cd03773
    Location:239 → 372
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cl17238
    Location:6 → 21
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  7. NM_001353083.2 → NP_001340012.1  E3 ubiquitin-protein ligase TRIM37 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (1) summary
    cd03773
    Location:28 → 161
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

  8. NM_001353084.2 → NP_001340013.1  E3 ubiquitin-protein ligase TRIM37 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (4) summary
    smart00502
    Location:132 → 254
    BBC; B-Box C-terminal domain
    smart00336
    Location:91 → 132
    BBOX; B-Box-type zinc finger
    cd03773
    Location:273 → 406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd16619
    Location:13 → 55
    mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

  9. NM_001353085.2 → NP_001340014.1  E3 ubiquitin-protein ligase TRIM37 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (2) summary
    cd03773
    Location:119 → 252
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cl25407
    Location:1 → 100
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  10. NM_001353086.2 → NP_001340015.1  E3 ubiquitin-protein ligase TRIM37 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (4) summary
    smart00502
    Location:132 → 254
    BBC; B-Box C-terminal domain
    smart00336
    Location:91 → 132
    BBOX; B-Box-type zinc finger
    cd03773
    Location:270 → 389
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd16619
    Location:13 → 55
    mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

  11. NM_015294.6 → NP_056109.1  E3 ubiquitin-protein ligase TRIM37 isoform a

    See identical proteins and their annotated locations for NP_056109.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same isoform (a).
    Source sequence(s)
    AB020705, AK289674, CN388771, DC351295
    Consensus CDS
    CCDS32694.1
    UniProtKB/Swiss-Prot
    A8K0V9, A8K8U4, A8MZ79, B4DGZ3, F8WEE6, O94972, Q7Z3E6, Q8IYF7, Q8WYF7
    Related
    ENSP00000262294.7, ENST00000262294.12
    Conserved Domains (4) summary
    smart00502
    Location:132 → 254
    BBC; B-Box C-terminal domain
    cd00162
    Location:15 → 58
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273 → 406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90 → 132
    zf-B_box; B-box zinc finger

RNA

  1. NR_148346.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Related
    ENST00000577554.5

  2. NR_148347.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    58967201..59106880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436110.1 → XP_047292066.1  E3 ubiquitin-protein ligase TRIM37 isoform X13

  2. XM_047436107.1 → XP_047292063.1  E3 ubiquitin-protein ligase TRIM37 isoform X9

  3. XM_047436111.1 → XP_047292067.1  E3 ubiquitin-protein ligase TRIM37 isoform X15

  4. XM_017024663.3 → XP_016880152.1  E3 ubiquitin-protein ligase TRIM37 isoform X4

  5. XM_017024662.2 → XP_016880151.1  E3 ubiquitin-protein ligase TRIM37 isoform X2

  6. XM_047436122.1 → XP_047292078.1  E3 ubiquitin-protein ligase TRIM37 isoform X29

  7. XM_047436121.1 → XP_047292077.1  E3 ubiquitin-protein ligase TRIM37 isoform X28

  8. XM_047436114.1 → XP_047292070.1  E3 ubiquitin-protein ligase TRIM37 isoform X19

  9. XM_047436113.1 → XP_047292069.1  E3 ubiquitin-protein ligase TRIM37 isoform X18

  10. XM_047436117.1 → XP_047292073.1  E3 ubiquitin-protein ligase TRIM37 isoform X23

  11. XM_017024667.2 → XP_016880156.1  E3 ubiquitin-protein ligase TRIM37 isoform X16

    Conserved Domains (4) summary
    smart00502
    Location:132 → 254
    BBC; B-Box C-terminal domain
    smart00336
    Location:91 → 132
    BBOX; B-Box-type zinc finger
    cd03773
    Location:270 → 389
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd16619
    Location:13 → 55
    mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

  12. XM_047436108.1 → XP_047292064.1  E3 ubiquitin-protein ligase TRIM37 isoform X10

  13. XM_047436123.1 → XP_047292079.1  E3 ubiquitin-protein ligase TRIM37 isoform X30

  14. XM_047436116.1 → XP_047292072.1  E3 ubiquitin-protein ligase TRIM37 isoform X21

  15. XM_047436115.1 → XP_047292071.1  E3 ubiquitin-protein ligase TRIM37 isoform X20

  16. XM_005257385.2 → XP_005257442.1  E3 ubiquitin-protein ligase TRIM37 isoform X6

    Conserved Domains (4) summary
    smart00502
    Location:132 → 254
    BBC; B-Box C-terminal domain
    smart00336
    Location:91 → 132
    BBOX; B-Box-type zinc finger
    cd03773
    Location:273 → 406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd16619
    Location:13 → 55
    mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

  17. XM_011524832.3 → XP_011523134.1  E3 ubiquitin-protein ligase TRIM37 isoform X3

    Conserved Domains (4) summary
    smart00502
    Location:132 → 254
    BBC; B-Box C-terminal domain
    cd00162
    Location:15 → 58
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273 → 406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90 → 132
    zf-B_box; B-box zinc finger

  18. XM_017024665.2 → XP_016880154.1  E3 ubiquitin-protein ligase TRIM37 isoform X11

  19. XM_047436106.1 → XP_047292062.1  E3 ubiquitin-protein ligase TRIM37 isoform X7

  20. XM_047436109.1 → XP_047292065.1  E3 ubiquitin-protein ligase TRIM37 isoform X12

  21. XM_011524831.2 → XP_011523133.1  E3 ubiquitin-protein ligase TRIM37 isoform X1

    Conserved Domains (4) summary
    smart00502
    Location:132 → 254
    BBC; B-Box C-terminal domain
    cd00162
    Location:15 → 58
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273 → 406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90 → 132
    zf-B_box; B-box zinc finger

  22. XM_011524836.2 → XP_011523138.1  E3 ubiquitin-protein ligase TRIM37 isoform X14

    Conserved Domains (4) summary
    smart00502
    Location:132 → 254
    BBC; B-Box C-terminal domain
    cd00162
    Location:15 → 58
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273 → 406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90 → 132
    zf-B_box; B-box zinc finger

  23. XM_047436112.1 → XP_047292068.1  E3 ubiquitin-protein ligase TRIM37 isoform X17

  24. XM_011524834.2 → XP_011523136.1  E3 ubiquitin-protein ligase TRIM37 isoform X8

    Conserved Domains (3) summary
    smart00502
    Location:98 → 220
    BBC; B-Box C-terminal domain
    cd03773
    Location:239 → 372
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:56 → 98
    zf-B_box; B-box zinc finger

  25. XM_011524833.2 → XP_011523135.1  E3 ubiquitin-protein ligase TRIM37 isoform X5

    Conserved Domains (4) summary
    smart00502
    Location:132 → 254
    BBC; B-Box C-terminal domain
    cd00162
    Location:15 → 58
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:270 → 389
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90 → 132
    zf-B_box; B-box zinc finger

  26. XM_047436118.1 → XP_047292074.1  E3 ubiquitin-protein ligase TRIM37 isoform X24

  27. XM_017024673.3 → XP_016880162.1  E3 ubiquitin-protein ligase TRIM37 isoform X34

  28. XM_047436125.1 → XP_047292081.1  E3 ubiquitin-protein ligase TRIM37 isoform X32

  29. XM_047436124.1 → XP_047292080.1  E3 ubiquitin-protein ligase TRIM37 isoform X31

  30. XM_017024669.3 → XP_016880158.1  E3 ubiquitin-protein ligase TRIM37 isoform X22

  31. XM_047436126.1 → XP_047292082.1  E3 ubiquitin-protein ligase TRIM37 isoform X33

  32. XM_047436120.1 → XP_047292076.1  E3 ubiquitin-protein ligase TRIM37 isoform X26

  33. XM_017024670.3 → XP_016880159.1  E3 ubiquitin-protein ligase TRIM37 isoform X27

  34. XM_047436119.1 → XP_047292075.1  E3 ubiquitin-protein ligase TRIM37 isoform X25

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    59835276..59974976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316201.1 → XP_054172176.1  E3 ubiquitin-protein ligase TRIM37 isoform X4

  2. XM_054316210.1 → XP_054172185.1  E3 ubiquitin-protein ligase TRIM37 isoform X13

  3. XM_054316212.1 → XP_054172187.1  E3 ubiquitin-protein ligase TRIM37 isoform X15

  4. XM_054316206.1 → XP_054172181.1  E3 ubiquitin-protein ligase TRIM37 isoform X9

  5. XM_054316199.1 → XP_054172174.1  E3 ubiquitin-protein ligase TRIM37 isoform X2

  6. XM_054316226.1 → XP_054172201.1  E3 ubiquitin-protein ligase TRIM37 isoform X29

  7. XM_054316225.1 → XP_054172200.1  E3 ubiquitin-protein ligase TRIM37 isoform X28

  8. XM_054316216.1 → XP_054172191.1  E3 ubiquitin-protein ligase TRIM37 isoform X19

  9. XM_054316215.1 → XP_054172190.1  E3 ubiquitin-protein ligase TRIM37 isoform X18

  10. XM_054316220.1 → XP_054172195.1  E3 ubiquitin-protein ligase TRIM37 isoform X23

  11. XM_054316213.1 → XP_054172188.1  E3 ubiquitin-protein ligase TRIM37 isoform X16

  12. XM_054316207.1 → XP_054172182.1  E3 ubiquitin-protein ligase TRIM37 isoform X10

  13. XM_054316227.1 → XP_054172202.1  E3 ubiquitin-protein ligase TRIM37 isoform X30

  14. XM_054316218.1 → XP_054172193.1  E3 ubiquitin-protein ligase TRIM37 isoform X21

  15. XM_054316217.1 → XP_054172192.1  E3 ubiquitin-protein ligase TRIM37 isoform X20

  16. XM_054316203.1 → XP_054172178.1  E3 ubiquitin-protein ligase TRIM37 isoform X6

  17. XM_054316200.1 → XP_054172175.1  E3 ubiquitin-protein ligase TRIM37 isoform X3

  18. XM_054316208.1 → XP_054172183.1  E3 ubiquitin-protein ligase TRIM37 isoform X11

  19. XM_054316204.1 → XP_054172179.1  E3 ubiquitin-protein ligase TRIM37 isoform X7

  20. XM_054316209.1 → XP_054172184.1  E3 ubiquitin-protein ligase TRIM37 isoform X12

  21. XM_054316198.1 → XP_054172173.1  E3 ubiquitin-protein ligase TRIM37 isoform X1

  22. XM_054316211.1 → XP_054172186.1  E3 ubiquitin-protein ligase TRIM37 isoform X14

  23. XM_054316214.1 → XP_054172189.1  E3 ubiquitin-protein ligase TRIM37 isoform X17

  24. XM_054316205.1 → XP_054172180.1  E3 ubiquitin-protein ligase TRIM37 isoform X8

  25. XM_054316202.1 → XP_054172177.1  E3 ubiquitin-protein ligase TRIM37 isoform X5

  26. XM_054316221.1 → XP_054172196.1  E3 ubiquitin-protein ligase TRIM37 isoform X24

  27. XM_054316231.1 → XP_054172206.1  E3 ubiquitin-protein ligase TRIM37 isoform X35

  28. XM_054316232.1 → XP_054172207.1  E3 ubiquitin-protein ligase TRIM37 isoform X34

  29. XM_054316229.1 → XP_054172204.1  E3 ubiquitin-protein ligase TRIM37 isoform X32

  30. XM_054316228.1 → XP_054172203.1  E3 ubiquitin-protein ligase TRIM37 isoform X31

  31. XM_054316219.1 → XP_054172194.1  E3 ubiquitin-protein ligase TRIM37 isoform X22

  32. XM_054316230.1 → XP_054172205.1  E3 ubiquitin-protein ligase TRIM37 isoform X33

  33. XM_054316223.1 → XP_054172198.1  E3 ubiquitin-protein ligase TRIM37 isoform X26

  34. XM_054316224.1 → XP_054172199.1  E3 ubiquitin-protein ligase TRIM37 isoform X27

  35. XM_054316222.1 → XP_054172197.1  E3 ubiquitin-protein ligase TRIM37 isoform X25

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94972.2 GenPept UniProtKB/Swiss-Prot:O94972

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