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NCAM2 neural cell adhesion molecule 2 [ Homo sapiens (human) ]

Gene ID: 4685, updated on 10-Dec-2024

Summary

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Official Symbol
NCAM2provided by HGNC
Official Full Name
neural cell adhesion molecule 2provided by HGNC
Primary source
HGNC:HGNC:7657
See related
Ensembl:ENSG00000154654 MIM:602040; AllianceGenome:HGNC:7657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCAM21
Summary
The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 13.1), adrenal (RPKM 3.2) and 3 other tissues See more
Orthologs
mouse all
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Genomic context

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See NCAM2 in Genome Data Viewer
Location:
21q21.1
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (20998409..21543329)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (19360795..19909385)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (22370727..22915650)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 1 Neighboring gene uncharacterized LOC124905057 Neighboring gene Sharpr-MPRA regulatory region 4841 Neighboring gene Sharpr-MPRA regulatory region 4883 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:22737134-22737706 Neighboring gene long intergenic non-protein coding RNA 317 Neighboring gene long intergenic non-protein coding RNA 1425

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition? Scholz C, et al. Eur J Med Genet, 2016 Oct. PMID 27596683
  2. Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy. Takahashi S, et al. Cancer Sci, 2011 Apr. PMID 21214674
  3. Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome. Paoloni-Giacobino A, et al. Genomics, 1997 Jul 1. PMID 9226371
  4. NCAM2/OCAM/RNCAM: cell adhesion molecule with a role in neuronal compartmentalization. Winther M, et al. Int J Biochem Cell Biol, 2012 Mar. PMID 22155300
  5. 21q21 deletion involving NCAM2: report of 3 cases with neurodevelopmental disorders. Petit F, et al. Eur J Med Genet, 2015 Jan. PMID 25464110

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3.
    Title: NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3.
  2. Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo.
    Title: Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo.
  3. These results reveal that the NCAM2 FnIII domains form a rigid structure that binds and activates FGFR in a manner related to, but different from NCAM1.
    Title: NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor.
  4. Our reported case raises the questions whether the NCAM2-deletion is the true cause of the autism spectrum disorder or only a risk factor and whether there might be any connection in NCAM2 with skull-size
    Title: NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition?
  5. Abeta-dependent disruption of NCAM2 functions in Alzheimer's disease hippocampus contributes to synapse loss.
    Title: Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease.
  6. A complete structural model of the entire ectodomain of human NCAM2 has been assembled from crystal structures of six recombinant proteins corresponding to different regions of the ectodomain.
    Title: Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule.
  7. High NCAM2 is associated with increased 5-Fluorouracil sensitivity in prostate and breast cancer.
    Title: Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy.
  8. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study on obesity and obesity-related traits.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
EBI GWAS Catalog
Joint influence of small-effect genetic variants on human longevity.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC51008

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonal fasciculation IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron cell-cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in synaptic membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neural cell adhesion molecule 2
Names
N-CAM-2
NCAM-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001352591.2 → NP_001339520.1  neural cell adhesion molecule 2 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001115, AP001137, AP001138, AP001252
    UniProtKB/TrEMBL
    H9KV31
    Conserved Domains (6) summary
    cd05866
    Location:21 → 112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:300 → 397
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:496 → 588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594 → 678
    fn3; Fibronectin type III domain
    pfam13927
    Location:401 → 479
    Ig_3; Immunoglobulin domain
    cl11960
    Location:208 → 301
    Ig; Immunoglobulin domain

  2. NM_001352592.2 → NP_001339521.1  neural cell adhesion molecule 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AP001115, AP001136, AP001137, AP001138, AP001252
    UniProtKB/TrEMBL
    H9KV31
    Conserved Domains (6) summary
    cd05866
    Location:46 → 137
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:325 → 422
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:521 → 613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:619 → 703
    fn3; Fibronectin type III domain
    pfam13927
    Location:426 → 504
    Ig_3; Immunoglobulin domain
    cl11960
    Location:233 → 326
    Ig; Immunoglobulin domain

  3. NM_001352593.2 → NP_001339522.1  neural cell adhesion molecule 2 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001137, AP001138, AP001252
    UniProtKB/TrEMBL
    H9KV31
    Conserved Domains (6) summary
    cd05866
    Location:21 → 112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:300 → 397
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:496 → 588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594 → 678
    fn3; Fibronectin type III domain
    pfam13927
    Location:401 → 479
    Ig_3; Immunoglobulin domain
    cl11960
    Location:208 → 301
    Ig; Immunoglobulin domain

  4. NM_001352594.2 → NP_001339523.1  neural cell adhesion molecule 2 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001137, AP001138, AP001252
    UniProtKB/TrEMBL
    H9KV31
    Conserved Domains (6) summary
    cd05866
    Location:21 → 112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:300 → 397
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:496 → 588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594 → 678
    fn3; Fibronectin type III domain
    pfam13927
    Location:401 → 479
    Ig_3; Immunoglobulin domain
    cl11960
    Location:208 → 301
    Ig; Immunoglobulin domain

  5. NM_001352595.2 → NP_001339524.1  neural cell adhesion molecule 2 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AK299054, AP001115, AP001137
    UniProtKB/TrEMBL
    B7Z5K2
    Conserved Domains (5) summary
    cd05870
    Location:158 → 255
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:354 → 446
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:452 → 536
    fn3; Fibronectin type III domain
    pfam13927
    Location:259 → 337
    Ig_3; Immunoglobulin domain
    cl11960
    Location:66 → 159
    Ig; Immunoglobulin domain

  6. NM_001352596.2 → NP_001339525.1  neural cell adhesion molecule 2 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AI500562, AP001137, AP001138, AP001252
    Conserved Domains (5) summary
    cd05866
    Location:21 → 112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:300 → 397
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:496 → 556
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam13927
    Location:401 → 479
    Ig_3; Immunoglobulin domain
    cl11960
    Location:208 → 301
    Ig; Immunoglobulin domain

  7. NM_001352597.2 → NP_001339526.1  neural cell adhesion molecule 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AK302870
    Conserved Domains (4) summary
    cd05866
    Location:46 → 137
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:325 → 422
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    pfam13927
    Location:147 → 212
    Ig_3; Immunoglobulin domain
    cl11960
    Location:233 → 326
    Ig; Immunoglobulin domain

  8. NM_004540.5 → NP_004531.2  neural cell adhesion molecule 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_004531.2

    Status: REVIEWED

    Source sequence(s)
    AI207079, AP001115, BC052946
    Consensus CDS
    CCDS42910.1
    UniProtKB/Swiss-Prot
    A8MQ06, B7Z841, O15394, Q7Z7F2
    UniProtKB/TrEMBL
    H9KV31
    Related
    ENSP00000383392.1, ENST00000400546.6
    Conserved Domains (8) summary
    cd05866
    Location:21 → 112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:300 → 397
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:414 → 482
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:308 → 395
    IG_like; Immunoglobulin like
    cd00063
    Location:496 → 588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:22 → 111
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:594 → 678
    fn3; Fibronectin type III domain
    cl11960
    Location:208 → 301
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    20998409..21543329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440785.1 → XP_047296741.1  neural cell adhesion molecule 2 isoform X6

    UniProtKB/TrEMBL
    H9KV31

  2. XM_024452081.2 → XP_024307849.1  neural cell adhesion molecule 2 isoform X7

    UniProtKB/TrEMBL
    H9KV31
    Conserved Domains (6) summary
    cd05866
    Location:21 → 112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:300 → 397
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:496 → 588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594 → 678
    fn3; Fibronectin type III domain
    pfam13927
    Location:401 → 479
    Ig_3; Immunoglobulin domain
    cl11960
    Location:208 → 301
    Ig; Immunoglobulin domain

  3. XM_011529575.4 → XP_011527877.1  neural cell adhesion molecule 2 isoform X1

    See identical proteins and their annotated locations for XP_011527877.1

    UniProtKB/TrEMBL
    H9KV31
    Conserved Domains (8) summary
    cd05870
    Location:325 → 422
    IgI_NCAM-2; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 2 (NCAM-2)
    smart00408
    Location:153 → 214
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:521 → 613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:619 → 703
    fn3; Fibronectin type III domain
    pfam13927
    Location:426 → 504
    Ig_3; Immunoglobulin domain
    cd00096
    Location:443 → 447
    Ig; Ig strand B [structural motif]
    cd05866
    Location:46 → 138
    IgI_1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2; member of the I-set of Ig superfamily (IgSF) domains
    cd20970
    Location:234 → 323
    IgI_1_MuSK; agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains

  4. XM_047440784.1 → XP_047296740.1  neural cell adhesion molecule 2 isoform X2

    UniProtKB/TrEMBL
    H9KV31

  5. XM_011529581.4 → XP_011527883.1  neural cell adhesion molecule 2 isoform X4

    UniProtKB/TrEMBL
    H9KV31
    Conserved Domains (8) summary
    cd05866
    Location:46 → 137
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:325 → 422
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:439 → 507
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:333 → 420
    IG_like; Immunoglobulin like
    cd00063
    Location:521 → 613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:47 → 136
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:619 → 703
    fn3; Fibronectin type III domain
    cl11960
    Location:233 → 326
    Ig; Immunoglobulin domain

  6. XM_011529580.4 → XP_011527882.1  neural cell adhesion molecule 2 isoform X3

    UniProtKB/TrEMBL
    H9KV31
    Conserved Domains (8) summary
    cd05866
    Location:46 → 137
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:325 → 422
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:439 → 507
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:333 → 420
    IG_like; Immunoglobulin like
    cd00063
    Location:521 → 613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:47 → 136
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:619 → 703
    fn3; Fibronectin type III domain
    cl11960
    Location:233 → 326
    Ig; Immunoglobulin domain

  7. XM_011529582.4 → XP_011527884.1  neural cell adhesion molecule 2 isoform X5

    UniProtKB/TrEMBL
    H9KV31
    Conserved Domains (8) summary
    cd05866
    Location:46 → 137
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:325 → 422
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:439 → 507
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:333 → 420
    IG_like; Immunoglobulin like
    cd00063
    Location:521 → 613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:47 → 136
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:619 → 703
    fn3; Fibronectin type III domain
    cl11960
    Location:233 → 326
    Ig; Immunoglobulin domain

  8. XM_017028356.3 → XP_016883845.1  neural cell adhesion molecule 2 isoform X8

    UniProtKB/TrEMBL
    B7Z5K2
    Conserved Domains (7) summary
    cd05870
    Location:136 → 233
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:250 → 318
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:144 → 231
    IG_like; Immunoglobulin like
    cd00063
    Location:332 → 424
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:51 → 134
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:430 → 514
    fn3; Fibronectin type III domain
    cl11960
    Location:44 → 137
    Ig; Immunoglobulin domain

  9. XM_011529585.3 → XP_011527887.1  neural cell adhesion molecule 2 isoform X8

    See identical proteins and their annotated locations for XP_011527887.1

    UniProtKB/TrEMBL
    B7Z5K2
    Conserved Domains (7) summary
    cd05870
    Location:136 → 233
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:250 → 318
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:144 → 231
    IG_like; Immunoglobulin like
    cd00063
    Location:332 → 424
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:51 → 134
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:430 → 514
    fn3; Fibronectin type III domain
    cl11960
    Location:44 → 137
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    19360795..19909385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324515.1 → XP_054180490.1  neural cell adhesion molecule 2 isoform X1

    UniProtKB/TrEMBL
    H9KV31

  2. XM_054324520.1 → XP_054180495.1  neural cell adhesion molecule 2 isoform X6

    UniProtKB/TrEMBL
    H9KV31

  3. XM_054324521.1 → XP_054180496.1  neural cell adhesion molecule 2 isoform X7

    UniProtKB/TrEMBL
    H9KV31

  4. XM_054324514.1 → XP_054180489.1  neural cell adhesion molecule 2 isoform X1

    UniProtKB/TrEMBL
    H9KV31

  5. XM_054324516.1 → XP_054180491.1  neural cell adhesion molecule 2 isoform X2

    UniProtKB/TrEMBL
    H9KV31

  6. XM_054324518.1 → XP_054180493.1  neural cell adhesion molecule 2 isoform X4

    UniProtKB/TrEMBL
    H9KV31

  7. XM_054324517.1 → XP_054180492.1  neural cell adhesion molecule 2 isoform X3

    UniProtKB/TrEMBL
    H9KV31

  8. XM_054324519.1 → XP_054180494.1  neural cell adhesion molecule 2 isoform X5

    UniProtKB/TrEMBL
    H9KV31

  9. XM_054324523.1 → XP_054180498.1  neural cell adhesion molecule 2 isoform X8

    UniProtKB/TrEMBL
    B7Z5K2

  10. XM_054324522.1 → XP_054180497.1  neural cell adhesion molecule 2 isoform X8

    UniProtKB/TrEMBL
    B7Z5K2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15394.2 GenPept UniProtKB/Swiss-Prot:O15394

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