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l(2)03659 lethal (2) 03659 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47905, updated on 2-Nov-2024

Summary

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Official Symbol
l(2)03659provided by FlyBase
Official Full Name
lethal (2) 03659provided by FlyBase
Primary source
FLYBASE:FBgn0010549
Locus tag
Dmel_CG8799
See related
AllianceGenome:FB:FBgn0010549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
A; CG11803; CG8799; DmCG8799; Dmel\CG8799; Dme_CG8799; hspr
Summary
Enables efflux transmembrane transporter activity and organic anion transmembrane transporter activity. Involved in organic anion transport. Predicted to be active in membrane. Is expressed in adult head and spermatozoon. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See l(2)03659 in Genome Data Viewer
Location:
45D1-45D1; 2-60 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9390165..9395281)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5277670..5282786)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 45a Neighboring gene uncharacterized protein Neighboring gene Outer dynein arm dynein axonemal light chain 1 Neighboring gene Novel nucleolar protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. eUnaG: a new ligand-inducible fluorescent reporter to detect drug transporter activity in live cells. Yeh JT, et al. Sci Rep, 2017 Feb 8. PMID 28176814, Free PMC Article
  2. The Drosophila protein Wunen repels migrating germ cells. Zhang N, et al. Nature, 1997 Jan 2. PMID 8985246
  3. Identification and genetic analysis of wunen, a gene guiding Drosophila melanogaster germ cell migration. Zhang N, et al. Genetics, 1996 Jul. PMID 8807296, Free PMC Article
  4. Drosophila protein kinase N (Pkn) is a negative regulator of actin-myosin activity during oogenesis. Ferreira T, et al. Dev Biol, 2014 Oct 15. PMID 25131196
  5. The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. Tarnay JN, et al. Insect Mol Biol, 2004 Oct. PMID 15373810

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables efflux transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in organic anion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IC
Inferred by Curator
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lethal (2) 03659
Names
CG8799-PB
CG8799-PC
Hsp related
l(2)03659-PB
l(2)03659-PC
NP_001260823.1
NP_610482.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9390165..9395281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136638.4 → NP_610482.3  lethal (2) 03659, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610482.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91660, Q9V571, Q9V572
    Conserved Domains (4) summary
    cd03244
    Location:1115 → 1336
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:499 → 699
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:89 → 1343
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:799 → 1045
    ABC_membrane; ABC transporter transmembrane region

  2. NM_001273894.1 → NP_001260823.1  lethal (2) 03659, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260823.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEG2
    Conserved Domains (4) summary
    cd03244
    Location:1115 → 1336
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:499 → 699
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:89 → 1343
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:799 → 1045
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEG2 A0A0B4KEG2
P91660.4 P91660

Gene LinkOut

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