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NTRK2 neurotrophic receptor tyrosine kinase 2 [ Homo sapiens (human) ]

Gene ID: 4915, updated on 27-Dec-2024

Summary

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Official Symbol
NTRK2provided by HGNC
Official Full Name
neurotrophic receptor tyrosine kinase 2provided by HGNC
Primary source
HGNC:HGNC:8032
See related
Ensembl:ENSG00000148053 MIM:600456; AllianceGenome:HGNC:8032
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBHD; TRKB; DEE58; trk-B; EIEE58; GP145-TrkB
Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Biased expression in brain (RPKM 64.6), thyroid (RPKM 30.4) and 3 other tissues See more
Orthologs
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Genomic context

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See NTRK2 in Genome Data Viewer
Location:
9q21.33
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (84668522..85027054)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (96818888..97177857)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (87283437..87641969)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:86892303-86893502 Neighboring gene SLC28A3 regulatory antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28504 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:86916903-86918102 Neighboring gene solute carrier family 28 member 3 Neighboring gene SLC28A3 intron nontranscribed chromatin-defined enhancer Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:86991346-86991846 Neighboring gene uncharacterized LOC102724036 Neighboring gene uncharacterized LOC124902192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19984 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:87127109-87128308 Neighboring gene NANOG hESC enhancer GRCh37_chr9:87185076-87185832 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28505 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19985 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28507 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28508 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:87323096-87324014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28510 Neighboring gene uncharacterized LOC124902193 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:87466721-87467920 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:87477172-87477672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:87569788-87570288 Neighboring gene uncharacterized LOC105376118 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:87659683-87660882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28511 Neighboring gene uncharacterized LOC107987088

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Higher serum tropomyosin-related kinase B protein level in major depression. Hung YY, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2010 May 30. PMID 20202475
  2. A common NTRK2 variant is associated with emotional arousal and brain white-matter integrity in healthy young subjects. Spalek K, et al. Transl Psychiatry, 2016 Mar 15. PMID 26978740, Free PMC Article
  3. Genomewide association scan of suicidal thoughts and behaviour in major depression. Schosser A, et al. PLoS One, 2011. PMID 21750702, Free PMC Article
  4. Neurotrophin Genes and Antidepressant-Worsening Suicidal Ideation: A Prospective Case-Control Study. Voegeli G, et al. Int J Neuropsychopharmacol, 2016 Nov. PMID 27378793, Free PMC Article
  5. Tyrosine receptor kinase B is a drug target in astrocytomas. Ni J, et al. Neuro Oncol, 2017 Jan. PMID 27402815, Free PMC Article

See all (404) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene.
    Title: Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene.
  2. Childhood urbanicity is associated with emotional episodic memory-related striatal function and common variation in NTRK2.
    Title: Childhood urbanicity is associated with emotional episodic memory-related striatal function and common variation in NTRK2.
  3. Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia.
    Title: Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia.
  4. TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury.
    Title: TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury.
  5. Association between NTRK2 Polymorphisms, Hippocampal Volumes and Treatment Resistance in Major Depressive Disorder.
    Title: Association between NTRK2 Polymorphisms, Hippocampal Volumes and Treatment Resistance in Major Depressive Disorder.
  6. miR-603 promotes cell proliferation and differentiation by targeting TrkB in acute promyelocytic leukemia.
    Title: miR-603 promotes cell proliferation and differentiation by targeting TrkB in acute promyelocytic leukemia.
  7. DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons.
    Title: DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons.
  8. TrkB inhibition of DJ-1 degradation promotes the growth and maintenance of cancer stem cell characteristics in hepatocellular carcinoma.
    Title: TrkB inhibition of DJ-1 degradation promotes the growth and maintenance of cancer stem cell characteristics in hepatocellular carcinoma.
  9. BDNF/TrkB Is a Crucial Regulator in the Inflammation-Mediated Odontoblastic Differentiation of Dental Pulp Stem Cells.
    Title: BDNF/TrkB Is a Crucial Regulator in the Inflammation-Mediated Odontoblastic Differentiation of Dental Pulp Stem Cells.
  10. Spitz Tumor With SQSTM1::NTRK2 Fusion: A Clinicopathological Study of 5 Cases.
    Title: Spitz Tumor With SQSTM1::NTRK2 Fusion: A Clinicopathological Study of 5 Cases.
Submit: New GeneRIF Correction See all GeneRIFs (302)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Developmental and epileptic encephalopathy, 58
MedGen: C4693367 OMIM: 617830 GeneReviews: Not available
Compare labs
Obesity, hyperphagia, and developmental delay
MedGen: C3151303 OMIM: 613886 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Variants close to NTRK2 gene are associated with birth weight in female twins.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) exposure downregulates TrkA, TrkB, and TrkC mRNA levels in dorsal root ganglion neurons PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GPI-linked ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables boss receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables brain-derived neurotrophic factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables brain-derived neurotrophic factor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables brain-derived neurotrophic factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables brain-derived neurotrophic factor receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables epidermal growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables hepatocyte growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXY142 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3Y41 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables insulin-like growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables macrophage colony-stimulating factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotrophin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables neurotrophin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables placental growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables platelet-derived growth factor alpha-receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables platelet-derived growth factor beta-receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine kinase collagen receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables stem cell factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane-ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables vascular endothelial growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Kit signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in brain-derived neurotrophic factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in brain-derived neurotrophic factor receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to brain-derived neurotrophic factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system neuron development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cerebral cortex development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian rhythm IEA
Inferred from Electronic Annotation
more info
  
involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ephrin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in feeding behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamate secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in hepatocyte growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in learning ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in macrophage colony-stimulating factor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in mechanoreceptor differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myelination in peripheral nervous system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of amyloid-beta formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of anoikis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuronal action potential propagation IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotrophin signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in peripheral nervous system neuron development IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retinal rod cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in trans-synaptic signaling by neuropeptide, modulating synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BDNF/NT-3 growth factors receptor
Names
BDNF-tropomyosine receptor kinase B
neurotrophic tyrosine kinase receptor type 2
tropomyosin-related kinase B
tyrosine kinase receptor B
NP_001007098.1
NP_001018074.1
NP_001018075.1
NP_001018076.1
NP_001278866.1
NP_001356461.1
NP_001356462.1
NP_001356463.1
NP_001356464.1
NP_001356465.1
NP_001356466.1
NP_001356467.1
NP_001356468.1
NP_001356469.1
NP_001356470.1
NP_001356471.1
NP_001356472.1
NP_001356473.1
NP_001356474.1
NP_001356475.1
NP_001356476.1
NP_001356477.1
NP_001356478.1
NP_001356479.1
NP_001356480.1
NP_001356481.1
NP_006171.2
XP_005252058.1
XP_005252060.1
XP_005252061.1
XP_011517020.1
XP_016870240.1
XP_016870241.1
XP_016870242.1
XP_016870244.1
XP_016870249.1
XP_047279388.1
XP_047279389.1
XP_054218993.1
XP_054218994.1
XP_054218995.1
XP_054218996.1
XP_054218997.1
XP_054218998.1
XP_054218999.1
XP_054219000.1
XP_054219001.1
XP_054219002.1
XP_054219003.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012201.2 RefSeqGene

    Range
    6179..363504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007097.3 → NP_001007098.1  BDNF/NT-3 growth factors receptor isoform b precursor

    See identical proteins and their annotated locations for NP_001007098.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b, also known as TrkB-T1) lacks several 3' exons but contains an alternate 3' terminal exon (exon 16 in PMID:11798182), and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern. Variants b and o-w all encode the same isoform (b).
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS35053.1
    UniProtKB/TrEMBL
    A0A8I5QKP8, Q5VWE5
    Related
    ENSP00000508622.1, ENST00000692506.1
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  2. NM_001018064.3 → NP_001018074.1  BDNF/NT-3 growth factors receptor isoform c precursor

    See identical proteins and their annotated locations for NP_001018074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) lacks an alternate in-frame exon in the central coding region, compared to variant a, resulting in an isoform (c) that is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern. Variants c, k, and l all encode the same isoform (c).
    Source sequence(s)
    AL390777, AL445532, AL596132
    Consensus CDS
    CCDS35050.1
    UniProtKB/Swiss-Prot
    B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7
    UniProtKB/TrEMBL
    A0A8I5KVH8, Q548C2
    Conserved Domains (6) summary
    cd05093
    Location:532 → 819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  3. NM_001018065.2 → NP_001018075.1  BDNF/NT-3 growth factors receptor isoform d precursor

    See identical proteins and their annotated locations for NP_001018075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (d, also known as TrkB-T-Shc) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern. Variants d and m both encode the same isoform (d).
    Source sequence(s)
    AB209118, AF410901, AL596132
    Consensus CDS
    CCDS35051.1
    UniProtKB/TrEMBL
    A0A8I5KUV8
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  4. NM_001018066.3 → NP_001018076.1  BDNF/NT-3 growth factors receptor isoform e precursor

    See identical proteins and their annotated locations for NP_001018076.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) lacks an alternate in-frame exon in the central coding region, and also lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (e, also known as TrkB-T-Shc) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern. Variants e and n both encode the same isoform (e).
    Source sequence(s)
    AL390777, AL596132
    Consensus CDS
    CCDS35052.1
    UniProtKB/TrEMBL
    A0A8I5KUV8
    Related
    ENSP00000365381.1, ENST00000376208.6
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  5. NM_001291937.2 → NP_001278866.1  BDNF/NT-3 growth factors receptor isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) uses an alternate in-frame splice site in the central coding region, and lacks several 3' exons but contains an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (f) has a distinct C-terminus and is shorter than isoform a. Variants f and x both encode the same isoform (f).
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS94428.1
    UniProtKB/TrEMBL
    A0A8I5KR47, A0A8I5QKP8
    Related
    ENSP00000510356.1, ENST00000686542.1
    Conserved Domains (6) summary
    cd05855
    Location:288 → 366
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    cl15307
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    pfam07679
    Location:205 → 283
    I-set; Immunoglobulin I-set domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat

  6. NM_001369532.1 → NP_001356461.1  BDNF/NT-3 growth factors receptor isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (k), as well as variants c and l, encodes isoform c.
    Source sequence(s)
    AL390777, AL445532, AL596132
    Consensus CDS
    CCDS35050.1
    UniProtKB/Swiss-Prot
    B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7
    UniProtKB/TrEMBL
    A0A8I5KVH8, Q548C2
    Related
    ENSP00000509743.1, ENST00000686259.1
    Conserved Domains (6) summary
    cd05093
    Location:532 → 819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  7. NM_001369533.1 → NP_001356462.1  BDNF/NT-3 growth factors receptor isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (l), as well as variants c and k, encodes isoform c.
    Source sequence(s)
    AL390777, AL445532, AL596132
    Consensus CDS
    CCDS35050.1
    UniProtKB/Swiss-Prot
    B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7
    UniProtKB/TrEMBL
    A0A8I5KVH8, Q548C2
    Related
    ENSP00000365386.1, ENST00000376213.6
    Conserved Domains (6) summary
    cd05093
    Location:532 → 819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  8. NM_001369534.1 → NP_001356463.1  BDNF/NT-3 growth factors receptor isoform g precursor

    Status: REVIEWED

    Source sequence(s)
    AL390777, AL445532, AL596132
    Consensus CDS
    CCDS94427.1
    UniProtKB/TrEMBL
    A0A8I5KVH8, A0A8J8YUT9
    Related
    ENSP00000314586.5, ENST00000323115.11
    Conserved Domains (5) summary
    cd05855
    Location:301 → 379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    cd05093
    Location:520 → 807
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    pfam07679
    Location:205 → 283
    I-set; Immunoglobulin I-set domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat

  9. NM_001369535.1 → NP_001356464.1  BDNF/NT-3 growth factors receptor isoform i

    Status: REVIEWED

    Source sequence(s)
    AL390777, AL445532, AL596132
    Consensus CDS
    CCDS94431.1
    UniProtKB/TrEMBL
    A0A8I5KZB7
    Related
    ENSP00000510766.1, ENST00000689301.1
    Conserved Domains (5) summary
    cd05093
    Location:376 → 663
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    cd00096
    Location:49 → 53
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:130 → 223
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:49 → 127
    Ig; Immunoglobulin domain
    cl15307
    Location:1 → 39
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  10. NM_001369536.1 → NP_001356465.1  BDNF/NT-3 growth factors receptor isoform h

    Status: REVIEWED

    Source sequence(s)
    AL390777, AL445532, AL596132
    Consensus CDS
    CCDS94430.1
    UniProtKB/TrEMBL
    A0A8I5KUZ1
    Related
    ENSP00000509020.1, ENST00000692473.1
    Conserved Domains (5) summary
    cd05093
    Location:392 → 679
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    cd00096
    Location:49 → 53
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:130 → 223
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:49 → 127
    Ig; Immunoglobulin domain
    cl15307
    Location:1 → 39
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  11. NM_001369537.1 → NP_001356466.1  BDNF/NT-3 growth factors receptor isoform d precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (m), as well as variant d, encodes isoform d.
    Source sequence(s)
    AL390777, AL596132
    Consensus CDS
    CCDS35051.1
    UniProtKB/TrEMBL
    A0A8I5KUV8
    Related
    ENSP00000508829.1, ENST00000687636.1
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  12. NM_001369538.1 → NP_001356467.1  BDNF/NT-3 growth factors receptor isoform e precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (n), as well as variant e, encodes isoform e.
    Source sequence(s)
    AL390777, AL596132
    Consensus CDS
    CCDS35052.1
    UniProtKB/TrEMBL
    A0A8I5KUV8
    Related
    ENSP00000306167.7, ENST00000304053.11
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  13. NM_001369539.1 → NP_001356468.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (o), as well as variants b and p-w, encodes isoform b.
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS35053.1
    UniProtKB/TrEMBL
    A0A8I5QKP8, Q5VWE5
    Related
    ENSP00000509058.1, ENST00000691415.1
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  14. NM_001369540.1 → NP_001356469.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (p), as well as variants b, o, and q-w, encodes isoform b.
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS35053.1
    UniProtKB/TrEMBL
    A0A8I5QKP8, Q5VWE5
    Related
    ENSP00000508443.1, ENST00000688013.1
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  15. NM_001369541.1 → NP_001356470.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (q), as well as variants b, o, p, and r-w, encodes isoform b.
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS35053.1
    UniProtKB/TrEMBL
    A0A8I5QKP8, Q5VWE5
    Related
    ENSP00000510451.1, ENST00000689815.1
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  16. NM_001369542.1 → NP_001356471.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (r), as well as variants b, o-q, and s-w, encodes isoform b.
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS35053.1
    UniProtKB/TrEMBL
    A0A8I5QKP8, Q5VWE5
    Related
    ENSP00000352906.3, ENST00000359847.4
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  17. NM_001369543.1 → NP_001356472.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (s), as well as variants b, o-r, and t-w, encodes isoform b.
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS35053.1
    UniProtKB/TrEMBL
    A0A8I5QKP8, Q5VWE5
    Related
    ENSP00000510071.1, ENST00000692762.1
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  18. NM_001369544.1 → NP_001356473.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (t), as well as variants b, o-s, and u-w, encodes isoform b.
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS35053.1
    UniProtKB/TrEMBL
    A0A8I5QKP8, Q5VWE5
    Related
    ENSP00000379221.1, ENST00000395882.6
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  19. NM_001369545.1 → NP_001356474.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (u), as well as variants b, o-t, v, and w, encodes isoform b.
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS35053.1
    UniProtKB/TrEMBL
    A0A8I5QKP8, Q5VWE5
    Related
    ENSP00000509169.1, ENST00000689685.1
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  20. NM_001369546.1 → NP_001356475.1  BDNF/NT-3 growth factors receptor isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (x), as well as variant f, encodes isoform f.
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS94428.1
    UniProtKB/TrEMBL
    A0A8I5KR47, A0A8I5QKP8
    Related
    ENSP00000509145.1, ENST00000693127.1
    Conserved Domains (6) summary
    cd05855
    Location:288 → 366
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    cl15307
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    pfam07679
    Location:205 → 283
    I-set; Immunoglobulin I-set domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat

  21. NM_001369547.1 → NP_001356476.1  BDNF/NT-3 growth factors receptor isoform j precursor

    Status: REVIEWED

    Source sequence(s)
    AL390777
    UniProtKB/TrEMBL
    A0A8I5KUV8
    Related
    ENSP00000508947.1, ENST00000690163.1
    Conserved Domains (6) summary
    cd05855
    Location:301 → 379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    cl15307
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    pfam07679
    Location:205 → 283
    I-set; Immunoglobulin I-set domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat

  22. NM_001369548.1 → NP_001356477.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (v), as well as variants b, o-u, and w, encodes isoform b.
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS35053.1
    UniProtKB/TrEMBL
    A0A8I5QKP8, Q5VWE5
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  23. NM_001369549.1 → NP_001356478.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (w), as well as variants b and o-v, encodes isoform b.
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS35053.1
    UniProtKB/TrEMBL
    A0A8I5QKP8, Q5VWE5
    Related
    ENSP00000510717.1, ENST00000687148.1
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  24. NM_001369550.1 → NP_001356479.1  BDNF/NT-3 growth factors receptor isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (y), as well as variants z and aa, encodes isoform k.
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS94429.1
    Related
    ENSP00000510032.1, ENST00000686322.1
    Conserved Domains (4) summary
    cd00096
    Location:49 → 53
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:130 → 223
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:49 → 127
    Ig; Immunoglobulin domain
    cl15307
    Location:1 → 39
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  25. NM_001369551.1 → NP_001356480.1  BDNF/NT-3 growth factors receptor isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (z), as well as variants y and aa, encodes isoform k.
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS94429.1
    Conserved Domains (4) summary
    cd00096
    Location:49 → 53
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:130 → 223
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:49 → 127
    Ig; Immunoglobulin domain
    cl15307
    Location:1 → 39
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  26. NM_001369552.1 → NP_001356481.1  BDNF/NT-3 growth factors receptor isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (aa), as well as variants y and z, encodes isoform k.
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS94429.1
    Related
    ENST00000691567.1
    Conserved Domains (4) summary
    cd00096
    Location:49 → 53
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:130 → 223
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:49 → 127
    Ig; Immunoglobulin domain
    cl15307
    Location:1 → 39
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  27. NM_006180.6 → NP_006171.2  BDNF/NT-3 growth factors receptor isoform a precursor

    See identical proteins and their annotated locations for NP_006171.2

    Status: REVIEWED

    Source sequence(s)
    AL390777, AL445532, AL596132
    Consensus CDS
    CCDS6671.1
    UniProtKB/TrEMBL
    A0A8I5KVH8
    Related
    ENSP00000277120.3, ENST00000277120.8
    Conserved Domains (6) summary
    cd05093
    Location:548 → 835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    84668522..85027054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014751.3 → XP_016870240.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVH8
    Conserved Domains (6) summary
    cd05093
    Location:548 → 835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  2. XM_017014753.3 → XP_016870242.1  BDNF/NT-3 growth factors receptor isoform X2

    UniProtKB/Swiss-Prot
    B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7
    UniProtKB/TrEMBL
    A0A8I5KVH8, Q548C2
    Related
    ENSP00000510060.1, ENST00000686496.1
    Conserved Domains (6) summary
    cd05093
    Location:532 → 819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  3. XM_047423432.1 → XP_047279388.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVH8

  4. XM_017014752.2 → XP_016870241.1  BDNF/NT-3 growth factors receptor isoform X2

    UniProtKB/Swiss-Prot
    B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7
    UniProtKB/TrEMBL
    A0A8I5KVH8, Q548C2
    Related
    ENSP00000510619.1, ENST00000692181.1
    Conserved Domains (6) summary
    cd05093
    Location:532 → 819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  5. XM_005252001.4 → XP_005252058.1  BDNF/NT-3 growth factors receptor isoform X1

    See identical proteins and their annotated locations for XP_005252058.1

    UniProtKB/TrEMBL
    A0A8I5KVH8
    Related
    ENSP00000510134.1, ENST00000686324.1
    Conserved Domains (6) summary
    cd05093
    Location:548 → 835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  6. XM_011518718.4 → XP_011517020.1  BDNF/NT-3 growth factors receptor isoform X2

    See identical proteins and their annotated locations for XP_011517020.1

    UniProtKB/Swiss-Prot
    B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7
    UniProtKB/TrEMBL
    A0A8I5KVH8, Q548C2
    Related
    ENSP00000509401.1, ENST00000691788.1
    Conserved Domains (6) summary
    cd05093
    Location:532 → 819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  7. XM_005252003.4 → XP_005252060.1  BDNF/NT-3 growth factors receptor isoform X1

    See identical proteins and their annotated locations for XP_005252060.1

    UniProtKB/TrEMBL
    A0A8I5KVH8
    Conserved Domains (6) summary
    cd05093
    Location:548 → 835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  8. XM_047423433.1 → XP_047279389.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVH8

  9. XM_005252004.3 → XP_005252061.1  BDNF/NT-3 growth factors receptor isoform X1

    See identical proteins and their annotated locations for XP_005252061.1

    UniProtKB/TrEMBL
    A0A8I5KVH8
    Conserved Domains (6) summary
    cd05093
    Location:548 → 835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  10. XM_017014755.1 → XP_016870244.1  BDNF/NT-3 growth factors receptor isoform X3

    UniProtKB/TrEMBL
    A0A8I5KUV8
    Related
    ENSP00000510640.1, ENST00000693539.1
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  11. XM_017014760.3 → XP_016870249.1  BDNF/NT-3 growth factors receptor isoform X4

    UniProtKB/TrEMBL
    A0A8I5QKP8, Q5VWE5
    Related
    ENSP00000508497.1, ENST00000692389.1
    Conserved Domains (7) summary
    sd00031
    Location:96 → 116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    96818888..97177857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363020.1 → XP_054218995.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVH8

  2. XM_054363024.1 → XP_054218999.1  BDNF/NT-3 growth factors receptor isoform X2

    UniProtKB/Swiss-Prot
    B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7
    UniProtKB/TrEMBL
    A0A8I5KVH8, Q548C2

  3. XM_054363018.1 → XP_054218993.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVH8

  4. XM_054363026.1 → XP_054219001.1  BDNF/NT-3 growth factors receptor isoform X2

    UniProtKB/Swiss-Prot
    B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7
    UniProtKB/TrEMBL
    A0A8I5KVH8, Q548C2

  5. XM_054363019.1 → XP_054218994.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVH8

  6. XM_054363025.1 → XP_054219000.1  BDNF/NT-3 growth factors receptor isoform X2

    UniProtKB/Swiss-Prot
    B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7
    UniProtKB/TrEMBL
    A0A8I5KVH8, Q548C2

  7. XM_054363021.1 → XP_054218996.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVH8

  8. XM_054363022.1 → XP_054218997.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVH8

  9. XM_054363023.1 → XP_054218998.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVH8

  10. XM_054363027.1 → XP_054219002.1  BDNF/NT-3 growth factors receptor isoform X3

    UniProtKB/TrEMBL
    A0A8I5KUV8

  11. XM_054363028.1 → XP_054219003.1  BDNF/NT-3 growth factors receptor isoform X4

    UniProtKB/TrEMBL
    A0A8I5QKP8, Q5VWE5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16620.1 GenPept UniProtKB/Swiss-Prot:Q16620

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