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NTRK3 neurotrophic receptor tyrosine kinase 3 [ Homo sapiens (human) ]

Gene ID: 4916, updated on 14-Nov-2024

Summary

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Official Symbol
NTRK3provided by HGNC
Official Full Name
neurotrophic receptor tyrosine kinase 3provided by HGNC
Primary source
HGNC:HGNC:8033
See related
Ensembl:ENSG00000140538 MIM:191316; AllianceGenome:HGNC:8033
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRKC; GP145-TrkC; gp145(trkC)
Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Expression
Biased expression in brain (RPKM 2.8), fat (RPKM 1.2) and 13 other tissues See more
Orthologs
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Genomic context

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See NTRK3 in Genome Data Viewer
Location:
15q25.3
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (87859751..88256739, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (85614323..86011407, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (88402982..88799970, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724465 Neighboring gene uncharacterized LOC124903579 Neighboring gene uncharacterized LOC124903580 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:88211934-88213133 Neighboring gene NANOG hESC enhancer GRCh37_chr15:88369377-88370100 Neighboring gene NANOG hESC enhancer GRCh37_chr15:88374259-88374825 Neighboring gene MPRA-validated peak2413 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:88418072-88418572 Neighboring gene microRNA 11181 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:88564569-88565768 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:88579975-88580784 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:88579163-88579974 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:88616236-88616831 Neighboring gene mediator complex subunit 28 pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:88784333-88784834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:88798114-88798651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:88798652-88799188 Neighboring gene Sharpr-MPRA regulatory region 8091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:88817782-88818282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:88818283-88818783 Neighboring gene uncharacterized LOC105370957 Neighboring gene uncharacterized LOC105370958 Neighboring gene NTRK3 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Relation between variants in the neurotrophin receptor gene, NTRK3, and white matter integrity in healthy young adults. Braskie MN, et al. Neuroimage, 2013 Nov 15. PMID 23727532, Free PMC Article
  2. Neurotrophin 3/TrkC-regulated proteins in the human medulloblastoma cell line DAOY. Gruber-Olipitz M, et al. Electrophoresis, 2009 Feb. PMID 19156760
  3. Trypanosoma cruzi promotes neuronal and glial cell survival through the neurotrophic receptor TrkC. Weinkauf C, et al. Infect Immun, 2009 Apr. PMID 19179422, Free PMC Article
  4. Decreased expression of neurotrophic tyrosine receptor kinase 3 is associated with the outflow tract defect of human tetralogy of Fallot. Kong B, et al. Chin Med J (Engl), 2009 Jan 20. PMID 19187638
  5. Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia. Otnaess MK, et al. Neurobiol Dis, 2009 Jun. PMID 19344762

See all (205) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas.
    Title: NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas.
  2. Expression and prognostic impact of NTF3 and TrkC in hepatocellular carcinoma.
    Title: Expression and prognostic impact of NTF3 and TrkC in hepatocellular carcinoma.
  3. Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression.
    Title: Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression.
  4. High-grade non-intestinal type sinonasal adenocarcinoma with ETV6::NTRK3 fusion, distinct from secretory carcinoma by immunoprofile and morphology.
    Title: High-grade non-intestinal type sinonasal adenocarcinoma with ETV6::NTRK3 fusion, distinct from secretory carcinoma by immunoprofile and morphology.
  5. TrkC, a novel prognostic marker, induces and maintains cell survival and metastatic dissemination of Ewing sarcoma by inhibiting EWSR1-FLI1 degradation.
    Title: TrkC, a novel prognostic marker, induces and maintains cell survival and metastatic dissemination of Ewing sarcoma by inhibiting EWSR1-FLI1 degradation.
  6. Prediction of EVT6-NTRK3-Dependent Papillary Thyroid Cancer Using Minor Expression Profile.
    Title: Prediction of EVT6-NTRK3-Dependent Papillary Thyroid Cancer Using Minor Expression Profile.
  7. Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC.
    Title: Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC.
  8. An unusual fusion gene EML4-ALK in a patient with congenital mesoblastic nephroma.
    Title: An unusual fusion gene EML4-ALK in a patient with congenital mesoblastic nephroma.
  9. [Clinicopathological features of NTRK3 gene rearrangement papillary thyroid carcinoma].
    Title: [Clinicopathological features of NTRK3 gene rearrangement papillary thyroid carcinoma].
  10. Fluorescent In Situ Hybridization Must be Preferred to pan-TRK Immunohistochemistry to Diagnose NTRK3-rearranged Gastrointestinal Stromal Tumors (GIST).
    Title: Fluorescent In Situ Hybridization Must be Preferred to pan-TRK Immunohistochemistry to Diagnose NTRK3-rearranged Gastrointestinal Stromal Tumors (GIST).
Submit: New GeneRIF Correction See all GeneRIFs (130)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of N370S homozygous Gaucher disease reveals the candidacy of CLN8 gene as a genetic modifier contributing to extreme phenotypic variation.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of neurotrophic tyrosine kinase, receptor, type 3 (NTRK3) by siRNA enhances HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) exposure downregulates TrkA, TrkB, and TrkC mRNA levels in dorsal root ganglion neurons PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GPI-linked ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables boss receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables brain-derived neurotrophic factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables epidermal growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables hepatocyte growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXY142 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3Y41 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables insulin-like growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables macrophage colony-stimulating factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotrophin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neurotrophin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neurotrophin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables p53 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables placental growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables platelet-derived growth factor alpha-receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables platelet-derived growth factor beta-receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase collagen receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables stem cell factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane-ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables vascular endothelial growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Kit signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to nerve growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ephrin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hepatocyte growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in macrophage colony-stimulating factor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotrophin signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of positive chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NT-3 growth factor receptor
Names
ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
ETV6-NTRK3 fusion
neurotrophic tyrosine kinase, receptor, type 3
tyrosine kinase receptor C
NP_001007157.1
NP_001012338.1
NP_001230030.1
NP_001307063.1
NP_001307064.1
NP_001362739.1
NP_001362740.1
NP_001362741.1
NP_001362742.1
NP_001362743.1
NP_002521.2
XP_006720608.1
XP_006720611.1
XP_006720612.1
XP_006720613.1
XP_011519940.1
XP_016877729.1
XP_016877730.1
XP_016877731.1
XP_016877732.1
XP_016877733.1
XP_016877734.1
XP_016877739.1
XP_016877740.1
XP_016877741.1
XP_016877743.1
XP_024305702.1
XP_024305703.1
XP_047288558.1
XP_047288559.1
XP_047288560.1
XP_054234029.1
XP_054234030.1
XP_054234031.1
XP_054234032.1
XP_054234033.1
XP_054234034.1
XP_054234035.1
XP_054234036.1
XP_054234037.1
XP_054234038.1
XP_054234039.1
XP_054234040.1
XP_054234041.1
XP_054234042.1
XP_054234043.1
XP_054234044.1
XP_054234045.1
XP_054234046.1
XP_054234047.1
XP_054234048.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029619.2 RefSeqGene

    Range
    5000..401988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007156.3 → NP_001007157.1  NT-3 growth factor receptor isoform c precursor

    See identical proteins and their annotated locations for NP_001007157.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC009711, AC021677
    Consensus CDS
    CCDS32323.1
    UniProtKB/TrEMBL
    Q96CY4, X5DP84
    Related
    ENSP00000318328.3, ENST00000317501.9
    Conserved Domains (6) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:31 → 56
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  2. NM_001012338.3 → NP_001012338.1  NT-3 growth factor receptor isoform a precursor

    See identical proteins and their annotated locations for NP_001012338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC009711, AC011966, AC021677
    Consensus CDS
    CCDS32322.1
    UniProtKB/Swiss-Prot
    B7Z4C5, E9PG56, H0YND1, O75682, Q12827, Q16288, Q16289
    UniProtKB/TrEMBL
    H0YM90, X5D2R1
    Related
    ENSP00000485864.1, ENST00000629765.3
    Conserved Domains (6) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05094
    Location:532 → 832
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  3. NM_001243101.2 → NP_001230030.1  NT-3 growth factor receptor isoform d precursor

    See identical proteins and their annotated locations for NP_001230030.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (d) has the same N- and C-termini but lacks two alternate internal segments compared to isoform a.
    Source sequence(s)
    AC009711, AC011966, AC021677
    Consensus CDS
    CCDS58399.1
    UniProtKB/TrEMBL
    H0YM90, X5DNW6
    Conserved Domains (6) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05094
    Location:524 → 810
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  4. NM_001320134.1 → NP_001307063.1  NT-3 growth factor receptor isoform e precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC021677, AF058390, AK309695, BM675026, S76476
    UniProtKB/TrEMBL
    X5DP84
    Conserved Domains (6) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:31 → 56
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  5. NM_001320135.2 → NP_001307064.1  NT-3 growth factor receptor isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding and non-coding regions, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform f) has a shorter N-terminus and a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC009711, AC011966, AC021677
    Consensus CDS
    CCDS81916.1
    UniProtKB/TrEMBL
    B7Z7U4, H0YM90
    Related
    ENSP00000437773.2, ENST00000542733.6
    Conserved Domains (7) summary
    cd04971
    Location:221 → 298
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:113 → 203
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00410
    Location:120 → 203
    IG_like; Immunoglobulin like
    sd00031
    Location:7 → 30
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:5 → 62
    LRR_8; Leucine rich repeat
    pfam16920
    Location:65 → 110
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl21453
    Location:434 → 614
    PKc_like; Protein Kinases, catalytic domain

  6. NM_001375810.1 → NP_001362739.1  NT-3 growth factor receptor isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC009711, AC011966, AC021677
    Consensus CDS
    CCDS32322.1
    UniProtKB/Swiss-Prot
    B7Z4C5, E9PG56, H0YND1, O75682, Q12827, Q16288, Q16289
    UniProtKB/TrEMBL
    H0YM90, X5D2R1
    Conserved Domains (6) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05094
    Location:532 → 832
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  7. NM_001375811.1 → NP_001362740.1  NT-3 growth factor receptor isoform b precursor

    Status: REVIEWED

    Source sequence(s)
    AC009711, AC011966, AC021677
    Consensus CDS
    CCDS10340.1
    UniProtKB/TrEMBL
    H0YM90, X5D7M5
    Conserved Domains (6) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05094
    Location:532 → 818
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  8. NM_001375812.1 → NP_001362741.1  NT-3 growth factor receptor isoform d precursor

    Status: REVIEWED

    Source sequence(s)
    AC009711, AC011966, AC021677
    Consensus CDS
    CCDS58399.1
    UniProtKB/TrEMBL
    H0YM90, X5DNW6
    Related
    ENSP00000453959.1, ENST00000557856.5
    Conserved Domains (6) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05094
    Location:524 → 810
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  9. NM_001375813.1 → NP_001362742.1  NT-3 growth factor receptor isoform c precursor

    Status: REVIEWED

    Source sequence(s)
    AC009711, AC021677
    Consensus CDS
    CCDS32323.1
    UniProtKB/TrEMBL
    Q96CY4, X5DP84
    Conserved Domains (6) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:31 → 56
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  10. NM_001375814.1 → NP_001362743.1  NT-3 growth factor receptor isoform g precursor

    Status: REVIEWED

    Source sequence(s)
    AC009711, AC021677
    UniProtKB/TrEMBL
    X5DP84
    Conserved Domains (6) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:31 → 56
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  11. NM_002530.4 → NP_002521.2  NT-3 growth factor receptor isoform b precursor

    See identical proteins and their annotated locations for NP_002521.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AC009711, AC011966, AC021677
    Consensus CDS
    CCDS10340.1
    UniProtKB/TrEMBL
    H0YM90, X5D7M5
    Related
    ENSP00000377990.1, ENST00000394480.6
    Conserved Domains (6) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05094
    Location:532 → 818
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    87859751..88256739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022240.2 → XP_016877729.1  NT-3 growth factor receptor isoform X1

    UniProtKB/TrEMBL
    H0YM90, X5D7M5
    Conserved Domains (6) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05094
    Location:532 → 818
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  2. XM_017022254.3 → XP_016877743.1  NT-3 growth factor receptor isoform X18

    UniProtKB/TrEMBL
    H0YM90
    Conserved Domains (8) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00219
    Location:538 → 835
    TyrKc; Tyrosine kinase, catalytic domain
    smart00410
    Location:218 → 301
    IG_like; Immunoglobulin like
    cd05094
    Location:532 → 843
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  3. XM_017022244.3 → XP_016877733.1  NT-3 growth factor receptor isoform X4

    UniProtKB/TrEMBL
    H0YM90

  4. XM_017022245.3 → XP_016877734.1  NT-3 growth factor receptor isoform X4

    UniProtKB/TrEMBL
    H0YM90

  5. XM_017022243.2 → XP_016877732.1  NT-3 growth factor receptor isoform X4

    UniProtKB/TrEMBL
    H0YM90

  6. XM_017022241.2 → XP_016877730.1  NT-3 growth factor receptor isoform X2

    UniProtKB/TrEMBL
    H0YM90

  7. XM_017022252.3 → XP_016877741.1  NT-3 growth factor receptor isoform X17

  8. XM_017022251.3 → XP_016877740.1  NT-3 growth factor receptor isoform X16

  9. XM_006720545.5 → XP_006720608.1  NT-3 growth factor receptor isoform X5

    UniProtKB/TrEMBL
    H0YM90
    Related
    ENSP00000453511.1, ENST00000558676.5
    Conserved Domains (7) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00410
    Location:218 → 301
    IG_like; Immunoglobulin like
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl21453
    Location:532 → 712
    PKc_like; Protein Kinases, catalytic domain

  10. XM_017022242.3 → XP_016877731.1  NT-3 growth factor receptor isoform X3

    UniProtKB/TrEMBL
    H0YM90

  11. XM_047432603.1 → XP_047288559.1  NT-3 growth factor receptor isoform X8

  12. XM_047432602.1 → XP_047288558.1  NT-3 growth factor receptor isoform X7

    Related
    ENSP00000511943.1, ENST00000695463.1

  13. XM_024449934.2 → XP_024305702.1  NT-3 growth factor receptor isoform X6

    UniProtKB/TrEMBL
    Q96CY4, X5DP84
    Conserved Domains (6) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:31 → 56
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  14. XM_024449935.2 → XP_024305703.1  NT-3 growth factor receptor isoform X9

    UniProtKB/TrEMBL
    X5DP84
    Conserved Domains (5) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  15. XM_006720548.5 → XP_006720611.1  NT-3 growth factor receptor isoform X10

    UniProtKB/TrEMBL
    X5DP84
    Conserved Domains (7) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:31 → 56
    LRRNT; Leucine rich repeat N-terminal domain
    smart00410
    Location:218 → 301
    IG_like; Immunoglobulin like
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  16. XM_006720550.5 → XP_006720613.1  NT-3 growth factor receptor isoform X12

    UniProtKB/TrEMBL
    X5DP84
    Conserved Domains (7) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:31 → 56
    LRRNT; Leucine rich repeat N-terminal domain
    smart00410
    Location:218 → 301
    IG_like; Immunoglobulin like
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  17. XM_006720549.5 → XP_006720612.1  NT-3 growth factor receptor isoform X11

    UniProtKB/TrEMBL
    X5DP84
    Conserved Domains (7) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:31 → 56
    LRRNT; Leucine rich repeat N-terminal domain
    smart00410
    Location:218 → 301
    IG_like; Immunoglobulin like
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  18. XM_011521638.4 → XP_011519940.1  NT-3 growth factor receptor isoform X14

    UniProtKB/TrEMBL
    X5DP84
    Conserved Domains (7) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:31 → 56
    LRRNT; Leucine rich repeat N-terminal domain
    smart00410
    Location:218 → 301
    IG_like; Immunoglobulin like
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  19. XM_047432604.1 → XP_047288560.1  NT-3 growth factor receptor isoform X15

  20. XM_017022250.3 → XP_016877739.1  NT-3 growth factor receptor isoform X13

    UniProtKB/TrEMBL
    X5DP84

RNA

  1. XR_001751292.3 RNA Sequence

  2. XR_002957645.2 RNA Sequence

  3. XR_001751293.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    85614323..86011407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378054.1 → XP_054234029.1  NT-3 growth factor receptor isoform X1

    UniProtKB/TrEMBL
    X5D7M5

  2. XM_054378073.1 → XP_054234048.1  NT-3 growth factor receptor isoform X18

  3. XM_054378057.1 → XP_054234032.1  NT-3 growth factor receptor isoform X4

  4. XM_054378059.1 → XP_054234034.1  NT-3 growth factor receptor isoform X4

  5. XM_054378058.1 → XP_054234033.1  NT-3 growth factor receptor isoform X4

  6. XM_054378055.1 → XP_054234030.1  NT-3 growth factor receptor isoform X2

  7. XM_054378072.1 → XP_054234047.1  NT-3 growth factor receptor isoform X17

  8. XM_054378071.1 → XP_054234046.1  NT-3 growth factor receptor isoform X16

  9. XM_054378060.1 → XP_054234035.1  NT-3 growth factor receptor isoform X5

  10. XM_054378056.1 → XP_054234031.1  NT-3 growth factor receptor isoform X3

  11. XM_054378063.1 → XP_054234038.1  NT-3 growth factor receptor isoform X8

  12. XM_054378062.1 → XP_054234037.1  NT-3 growth factor receptor isoform X7

  13. XM_054378061.1 → XP_054234036.1  NT-3 growth factor receptor isoform X6

    UniProtKB/TrEMBL
    Q96CY4

  14. XM_054378064.1 → XP_054234039.1  NT-3 growth factor receptor isoform X9

  15. XM_054378065.1 → XP_054234040.1  NT-3 growth factor receptor isoform X10

  16. XM_054378067.1 → XP_054234042.1  NT-3 growth factor receptor isoform X12

  17. XM_054378066.1 → XP_054234041.1  NT-3 growth factor receptor isoform X11

  18. XM_054378069.1 → XP_054234044.1  NT-3 growth factor receptor isoform X14

  19. XM_054378070.1 → XP_054234045.1  NT-3 growth factor receptor isoform X15

  20. XM_054378068.1 → XP_054234043.1  NT-3 growth factor receptor isoform X13

RNA

  1. XR_008488951.1 RNA Sequence

  2. XR_008488953.1 RNA Sequence

  3. XR_008488952.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16288.2 GenPept UniProtKB/Swiss-Prot:Q16288

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