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gja12.1 gap junction protein, alpha 12.1 [ Danio rerio (zebrafish) ]

Gene ID: 492358, updated on 4-Jan-2025

Summary

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Official Symbol
gja12.1provided by ZNC
Official Full Name
gap junction protein, alpha 12.1provided by ZNC
Primary source
ZFIN:ZDB-GENE-041114-200
See related
Ensembl:ENSDARG00000041797 AllianceGenome:ZFIN:ZDB-GENE-041114-200
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gjac; cx20c; cx28.9; fd51f05; zgc:92056; wu:fd51f05; si:dkey-261a18.3
Summary
Predicted to enable gap junction channel activity. Predicted to be involved in cell-cell signaling. Predicted to act upstream of or within cell communication. Predicted to be located in gap junction and plasma membrane. Predicted to be part of connexin complex. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human GJA4 (gap junction protein alpha 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See gja12.1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (40744754..40750964, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (40847644..40853841, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene gap junction protein alpha 13.2 Neighboring gene gap junction protein alpha 12.2 Neighboring gene gap junction protein alpha 13.1 Neighboring gene gap junction protein, alpha 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutations in connexin43 (GJA1) perturb bone growth in zebrafish fins. Iovine MK, et al. Dev Biol, 2005 Feb 1. PMID 15649473
  2. Phylogeny of teleost connexins reveals highly inconsistent intra- and interspecies use of nomenclature and misassemblies in recent teleost chromosome assemblies. Mikalsen SO, et al. BMC Genomics, 2020 Mar 11. PMID 32160866, Free PMC Article
  3. Evolutionary selection pressure and family relationships among connexin genes. Cruciani V, et al. Biol Chem, 2007 Mar. PMID 17338632
  4. Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes. Eastman SD, et al. Genomics, 2006 Feb. PMID 16337772
  5. The minimal gap-junction network among melanophores and xanthophores required for stripe pattern formation in zebrafish. Usui Y, et al. Development, 2019 Nov 15. PMID 31666235

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables gap junction channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell communication IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
part_of connexin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of connexin complex IEA
Inferred from Electronic Annotation
more info
  
located_in gap junction IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gap junction protein, alpha 12.1
Names
connexin 28.9
gap junction protein, alpha c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007324.1 → NP_001007325.1  gap junction protein, alpha 12.1

    See identical proteins and their annotated locations for NP_001007325.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085626
    UniProtKB/TrEMBL
    Q5TYN9, Q5U3B3
    Related
    ENSDARP00000061255.3, ENSDART00000061256.5
    Conserved Domains (3) summary
    smart00037
    Location:44 → 76
    CNX; Connexin homologues
    smart01089
    Location:151 → 217
    Connexin_CCC; Gap junction channel protein cysteine-rich domain
    pfam00029
    Location:3 → 219
    Connexin; Connexin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    40744754..40750964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170175.5 → XP_005170232.1  gap junction protein, alpha 12.1 isoform X1

    See identical proteins and their annotated locations for XP_005170232.1

    UniProtKB/TrEMBL
    Q5TYN9, Q5U3B3
    Conserved Domains (3) summary
    smart00037
    Location:44 → 76
    CNX; Connexin homologues
    smart01089
    Location:151 → 217
    Connexin_CCC; Gap junction channel protein cysteine-rich domain
    pfam00029
    Location:3 → 219
    Connexin; Connexin
Nucleotide Protein Strain
Heading Accession and Version

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