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cyp3c3 cytochrome P450, family 3, subfamily c, polypeptide 3 [ Danio rerio (zebrafish) ]

Gene ID: 492759, updated on 17-Sep-2024

Summary

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Official Symbol
cyp3c3provided by ZNC
Official Full Name
cytochrome P450, family 3, subfamily c, polypeptide 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-041114-102
See related
Ensembl:ENSDARG00000037873 AllianceGenome:ZFIN:ZDB-GENE-041114-102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cyp3c1l2; zgc:101781
Summary
Predicted to enable steroid hydroxylase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including adaxial cell; heart; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A4 (cytochrome P450 family 3 subfamily A member 4); CYP3A43 (cytochrome P450 family 3 subfamily A member 43); and CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See cyp3c3 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (40947961..40955782, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (40806103..40813924, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene forkhead box K1 Neighboring gene cytochrome P450, family 3, subfamily C, polypeptide 4 Neighboring gene cytochrome P450, family 3, subfamily c, polypeptide 2 Neighboring gene cytochrome P450, family 3, subfamily c, polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression patterns of cytochrome P450 3B and 3C genes in model fish species. Shaya L, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2014 Nov. PMID 25073111
  2. CYP3C1, the first member of a new cytochrome P450 subfamily found in zebrafish (Danio rerio). Corley-Smith GE, et al. Biochem Biophys Res Commun, 2006 Feb 24. PMID 16414346
  3. CYP3C gene regulation by the aryl hydrocarbon and estrogen receptors in zebrafish. Shaya L, et al. Toxicol Appl Pharmacol, 2019 Jan 1. PMID 30393146
  4. Rapid birth-death evolution specific to xenobiotic cytochrome P450 genes in vertebrates. Thomas JH. PLoS Genet, 2007 May 11. PMID 17500592, Free PMC Article
  5. Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish. Nawaji T, et al. Pharmaceuticals (Basel), 2020 Dec 11. PMID 33322603, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 3C3
Names
cytochrome P450, family 3, subfamily c, polypeptide 1 like, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007400.2 → NP_001007401.2  cytochrome P450 3C3

    Status: VALIDATED

    Source sequence(s)
    BX649536
    UniProtKB/TrEMBL
    A0A8M6Z4Z2, E7EY99
    Related
    ENSDARP00000109527.2, ENSDART00000130130.4
    Conserved Domains (1) summary
    pfam00067
    Location:38 → 496
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    40947961..40955782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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