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zdhhc13 zinc finger DHHC-type palmitoyltransferase 13 [ Danio rerio (zebrafish) ]

Gene ID: 494107, updated on 2-Nov-2024

Summary

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Official Symbol
zdhhc13provided by ZNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 13provided by ZNC
Primary source
ZFIN:ZDB-GENE-041212-79
See related
Ensembl:ENSDARG00000101144 AllianceGenome:ZFIN:ZDB-GENE-041212-79
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
DHHC-13; fi22e09; wu:fb06e01; wu:fc39g10; wu:fi22e09; zgc:101690
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Acts upstream of or within BMP signaling pathway; regulation of BMP signaling pathway; and regulation of ectodermal cell fate specification. Predicted to be located in Golgi apparatus and cytoplasmic vesicle membrane. Predicted to be active in Golgi membrane. Is expressed in blastoderm; blastomere; and head. Orthologous to human ZDHHC13 (zinc finger DHHC-type palmitoyltransferase 13). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See zdhhc13 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (16509245..16546131)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (16257272..16294158)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496157 Neighboring gene uncharacterized LOC137496159 Neighboring gene metallophosphoesterase domain containing 2a Neighboring gene transfer RNA arginine (anticodon UCG) Neighboring gene cysteine and glycine-rich protein 3 (cardiac LIM protein)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zinc finger DHHC-type containing 13 regulates fate specification of ectoderm and mesoderm cell lineages by modulating Smad6 activity. Chen X, et al. Stem Cells Dev, 2014 Aug 15. PMID 24702307
  2. Evolution of the vertebrate Pax4/6 class of genes with focus on its novel member, the Pax10 gene. Feiner N, et al. Genome Biol Evol, 2014 Jun 19. PMID 24951566, Free PMC Article
  3. 2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Wang C, et al. Neurotoxicol Teratol, 2015 Jul-Aug. PMID 26056731
  4. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesodermal cell fate specification IC
Inferred by Curator
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of ectodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative palmitoyltransferase ZDHHC13
Names
DHHC domain-containing protein 13
palmitoyltransferase ZDHHC13
zinc finger DHHC domain-containing protein 13
zinc finger DHHC-type containing 13
NP_001008650.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008650.3 → NP_001008650.2  putative palmitoyltransferase ZDHHC13

    Status: VALIDATED

    Source sequence(s)
    CU041375, EH546849, EH547414
    UniProtKB/Swiss-Prot
    A0A0R4IQZ2, Q5PRB8
    Related
    ENSDARP00000142710.1, ENSDART00000173777.2
    Conserved Domains (4) summary
    PHA03095
    Location:115 → 312
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:62 → 204
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:76 → 102
    ANK; ANK repeat [structural motif]
    pfam01529
    Location:450 → 580
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    16509245..16546131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0R4IQZ2.1 GenPept UniProtKB/Swiss-Prot:A0A0R4IQZ2

Gene LinkOut

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