tnni2a.4 troponin I type 2a (skeletal, fast), tandem duplicate 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tnni2a.4provided by ZNC
Official Full Name: troponin I type 2a (skeletal, fast), tandem duplicate 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-119
See related: Ensembl:ENSDARG00000029069 AllianceGenome:ZFIN:ZDB-GENE-040625-119
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tnni2; tropI-1d; zgc:86800; hm:zehn0173
Summary: Predicted to enable actin binding activity. Acts upstream of or within myofibril assembly. Predicted to be part of troponin complex. Is expressed in musculature system and somite. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; distal arthrogryposis type 2B1; and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including TNNI2 (troponin I2, fast skeletal type). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (31277415..31288725)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (30699939..30711250)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show thattnni1 and tnni2 transcripts were not detectable in the somites until 16 h post-fertilization (hpf), after which they were identified as slow-and fast muscle-specific, respectively.
Title: The molecular structures and expression patterns of zebrafish troponin I genes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of troponin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: troponin I type 2a (skeletal, fast), tandem duplicate 4

Names: fast muscle troponin I; troponin I type 2 (skeletal, fast); troponin I, skeletal, fast 2a, tandem duplicate 4; troponin I, skeletal, fast 2a.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009901.2 → NP_001009901.2 troponin I type 2a (skeletal, fast), tandem duplicate 4 precursor

See identical proteins and their annotated locations for NP_001009901.2

Status: VALIDATED

Source sequence(s)

CU462909, EB796259, EH580093

UniProtKB/TrEMBL

B3DG18, F6PFF2, Q0D2W2

Related

ENSDARP00000037759.5, ENSDART00000036275.6

Conserved Domains (2) summary

pfam00755
Location:32 → 120

Carn_acyltransf; Choline/Carnitine o-acyltransferase

pfam00992
Location:11 → 141

Troponin; Troponin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

31277415..31288725

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163149.5 → XP_005163206.1 troponin I type 2a (skeletal, fast), tandem duplicate 4 isoform X1

UniProtKB/TrEMBL

A0A8M2BA47

Conserved Domains (2) summary

pfam00755
Location:34 → 122

Carn_acyltransf; Choline/Carnitine o-acyltransferase

pfam00992
Location:13 → 143

Troponin; Troponin