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Eva1a eva-1 homolog A, regulator of programmed cell death [ Rattus norvegicus (Norway rat) ]

Gene ID: 500221, updated on 17-Aug-2024

Summary

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Symbol
Eva1aprovided by RGD
Full Name
eva-1 homolog A, regulator of programmed cell deathprovided by RGD
Primary source
RGD:1559797
See related
EnsemblRapid:ENSRNOG00000007118 AllianceGenome:RGD:1559797
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam176a; Tmem166; RGD1559797
Summary
Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Orthologous to human EVA1A (eva-1 homolog A, regulator of programmed cell death). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 81.3), Liver (RPKM 66.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eva1a in Genome Data Viewer
Location:
4q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (116151595..116200827)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (114593773..114643011)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (112714023..112823659)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene GC-rich sequence DNA-binding factor 2 Neighboring gene mitochondrial ribosomal protein L19 Neighboring gene peroxiredoxin 6, pseudogene 2 Neighboring gene tachykinin receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats. Li L, et al. Exp Neurol, 2012 Mar. PMID 22227058
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein eva-1 homolog A
Names
family with sequence similarity 176, member A
protein FAM176A
transmembrane protein 166

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109243.1 → NP_001102713.1  protein eva-1 homolog A

    See identical proteins and their annotated locations for NP_001102713.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473957
    UniProtKB/TrEMBL
    A6IAH4, D4A3V0
    Related
    ENSRNOP00000009321.5, ENSRNOT00000009321.7
    Conserved Domains (1) summary
    pfam14851
    Location:20 → 159
    FAM176; FAM176 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    116151595..116200827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108150.2 → XP_038964078.1  protein eva-1 homolog A isoform X3

    Conserved Domains (1) summary
    pfam14851
    Location:1 → 98
    FAM176; FAM176 family

  2. XM_006236708.5 → XP_006236770.1  protein eva-1 homolog A isoform X1

    See identical proteins and their annotated locations for XP_006236770.1

    UniProtKB/TrEMBL
    A6IAH4, D4A3V0
    Conserved Domains (1) summary
    pfam14851
    Location:20 → 159
    FAM176; FAM176 family

  3. XM_039108149.2 → XP_038964077.1  protein eva-1 homolog A isoform X2

    Conserved Domains (1) summary
    pfam14851
    Location:3 → 126
    FAM176; FAM176 family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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