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OSM oncostatin M [ Homo sapiens (human) ]

Gene ID: 5008, updated on 2-Nov-2024

Summary

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Official Symbol
OSMprovided by HGNC
Official Full Name
oncostatin Mprovided by HGNC
Primary source
HGNC:HGNC:8506
See related
Ensembl:ENSG00000099985 MIM:165095; AllianceGenome:HGNC:8506
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Expression
Biased expression in bone marrow (RPKM 29.4), appendix (RPKM 5.8) and 4 other tissues See more
Orthologs
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Genomic context

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See OSM in Genome Data Viewer
Location:
22q12.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (30262829..30266851, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (30726147..30730169, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30658818..30662840, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30637625-30638293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30640698-30641198 Neighboring gene LIF antisense RNA 1 Neighboring gene LIF interleukin 6 family cytokine Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30648163-30648928 Neighboring gene LIF antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30648929-30649693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30650183-30650684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30650685-30651184 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:30653067-30653669 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:30653670-30654271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30656529-30657028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30659020-30659819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30659820-30660618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:30672215-30672804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30673676-30674204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30674205-30674733 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18831 Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1 Neighboring gene TBC1 domain family member 10A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18832 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30700665-30701164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18836 Neighboring gene origin of replication in TBC1D10A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:30721337-30722286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13608

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Integrated MicroRNA-mRNA Profiling Identifies Oncostatin M as a Marker of Mesenchymal-Like ER-Negative/HER2-Negative Breast Cancer. Bottai G, et al. Int J Mol Sci, 2017 Jan 19. PMID 28106823, Free PMC Article
  2. Molecular dissection of human oncostatin M-mediated signal transductions through site-directed mutagenesis. Liu H, et al. Int J Mol Med, 2009 Feb. PMID 19148539
  3. Immunohistochemical localization of oncostatin M in epithelialized apical periodontitis lesions. Tsai CH, et al. Int Endod J, 2008 Sep. PMID 18637848
  4. Effect of human papillomavirus 16 oncoproteins on oncostatin M upregulation in oral squamous cell carcinoma. Chuerduangphui J, et al. Med Oncol, 2016 Aug. PMID 27349249
  5. Expression of oncostatin M in chronic obstructive sialadenitis of the submandibular gland. Lee HM, et al. Ann Otol Rhinol Laryngol, 2008 May. PMID 18564531

See all (193) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The causal relationship between immune cells mediating FIT3L, CCL4, OSM, and skin-derived deteriorated tumors.
    Title: The causal relationship between immune cells mediating FIT3L, CCL4, OSM, and skin-derived deteriorated tumors.
  2. Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M.
    Title: Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M.
  3. Oncostatin M for characterizing the inflammatory burden and outcome of V-V ECMO in ARDS patients.
    Title: Oncostatin M for characterizing the inflammatory burden and outcome of V-V ECMO in ARDS patients.
  4. Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching.
    Title: Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching.
  5. Role of oncostatin-M in ECM remodeling and plaque vulnerability.
    Title: Role of oncostatin-M in ECM remodeling and plaque vulnerability.
  6. Pancreatic Stromal Cell-derived Oncostatin M Confers Drug Resistance to a Multi-tyrosine Kinase Inhibitor in Pancreatic Cancer Cells.
    Title: Pancreatic Stromal Cell-derived Oncostatin M Confers Drug Resistance to a Multi-tyrosine Kinase Inhibitor in Pancreatic Cancer Cells.
  7. Evidence that oncostatin M synergizes with IL-4 signaling to induce TSLP expression in chronic rhinosinusitis with nasal polyps.
    Title: Evidence that oncostatin M synergizes with IL-4 signaling to induce TSLP expression in chronic rhinosinusitis with nasal polyps.
  8. Oncostatin M Contributes to Airway Epithelial Cell Dysfunction in Chronic Rhinosinusitis with Nasal Polyps.
    Title: Oncostatin M Contributes to Airway Epithelial Cell Dysfunction in Chronic Rhinosinusitis with Nasal Polyps.
  9. Exogenous Oncostatin M induces Cardiac Dysfunction, Musculoskeletal Atrophy, and Fibrosis.
    Title: Exogenous Oncostatin M induces Cardiac Dysfunction, Musculoskeletal Atrophy, and Fibrosis.
  10. Oncostatin M Improves Cutaneous Wound Re-Epithelialization and Is Deficient under Diabetic Conditions.
    Title: Oncostatin M Improves Cutaneous Wound Re-Epithelialization and Is Deficient under Diabetic Conditions.
Submit: New GeneRIF Correction See all GeneRIFs (152)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies susceptibility loci for IgA nephropathy.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of oncostatin M (OSM) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef specifically incorporates CSF2, PPBP (NAP2), CCL5, TNF, FAS, CXCL1, IL12B, MIF and OSM into plasma extracellular vesicles from HIV-1 infected patient samples PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC20461

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables growth factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oncostatin-M receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of hormone secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oncostatin-M-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of acute inflammatory response IC
Inferred by Curator
more info
 PubMed 
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of positive regulation of interleukin-17 production IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of hematopoietic stem cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
oncostatin-M

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319108.2 → NP_001306037.1  oncostatin-M isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus and lacks a predicted signal peptide compared to isoform 1.
    Source sequence(s)
    AC004264, BC011589, BM562358
    Consensus CDS
    CCDS82706.1
    UniProtKB/TrEMBL
    B5BUQ7, B5MCX1
    Related
    ENSP00000383893.1, ENST00000403389.1
    Conserved Domains (1) summary
    pfam01291
    Location:16 → 188
    LIF_OSM; LIF / OSM family

  2. NM_020530.6 → NP_065391.1  oncostatin-M isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_065391.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004264, BC011589, CR981101
    Consensus CDS
    CCDS13873.1
    UniProtKB/Swiss-Prot
    P13725, Q6FHP8, Q9UCP6
    UniProtKB/TrEMBL
    B5BUQ7
    Related
    ENSP00000215781.2, ENST00000215781.3
    Conserved Domains (1) summary
    pfam01291
    Location:37 → 209
    LIF_OSM; LIF / OSM family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    30262829..30266851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441387.1 → XP_047297343.1  oncostatin-M isoform X1

    UniProtKB/TrEMBL
    B5MCX1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    30726147..30730169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325661.1 → XP_054181636.1  oncostatin-M isoform X1

    UniProtKB/TrEMBL
    B5MCX1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13725.2 GenPept UniProtKB/Swiss-Prot:P13725

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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