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Tmem117 transmembrane protein 117 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500921, updated on 17-Aug-2024

Summary

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Official Symbol
Tmem117provided by RGD
Official Full Name
transmembrane protein 117provided by RGD
Primary source
RGD:1562562
See related
EnsemblRapid:ENSRNOG00000006068 AllianceGenome:RGD:1562562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562562
Summary
Predicted to be involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum and plasma membrane. Orthologous to human TMEM117 (transmembrane protein 117). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 122.3), Kidney (RPKM 88.2) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem117 in Genome Data Viewer
Location:
7q35
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (127636862..128098944)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (125757591..126219692)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (135880294..136403012)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B4, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene twinfilin actin-binding protein 1 Neighboring gene uncharacterized LOC120093715 Neighboring gene uncharacterized LOC102546578 Neighboring gene neural EGFL like 2 Neighboring gene uncharacterized LOC134479780 Neighboring gene uncharacterized LOC120093716

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel transmembrane protein defines the endoplasmic reticulum stress-induced cell death pathway. Tamaki T, et al. Biochem Biophys Res Commun, 2017 Apr 22. PMID 28285135
  2. Intrinsic Disorder in Transmembrane Proteins: Roles in Signaling and Topology Prediction. Bürgi J, et al. PLoS One, 2016. PMID 27391701, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 117

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271239.1 → NP_001258168.1  transmembrane protein 117

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    F1LWX9
    Related
    ENSRNOP00000008159.7, ENSRNOT00000008159.8
    Conserved Domains (1) summary
    pfam15113
    Location:4 → 403
    TMEM117; TMEM117 protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    127636862..128098944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079771.2 → XP_038935699.1  transmembrane protein 117 isoform X1

  2. XM_063264145.1 → XP_063120215.1  transmembrane protein 117 isoform X2

    UniProtKB/TrEMBL
    A6K7V3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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