crabp2b cellular retinoic acid binding protein 2, b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: crabp2bprovided by ZNC
Official Full Name: cellular retinoic acid binding protein 2, bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050208-52
See related: Ensembl:ENSDARG00000030449 AllianceGenome:ZFIN:ZDB-GENE-050208-52
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7136989
Summary: Predicted to enable fatty acid binding activity and retinoic acid binding activity. Acts upstream of or within hindbrain morphogenesis and regulation of retinoic acid receptor signaling pathway. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including eye; neural keel; neural plate; optic vesicle; and pectoral fin. Orthologous to human CRABP2 (cellular retinoic acid binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (8973042..8977405)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (9054117..9061108)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish Crabp2a and Crabp2b are essential for expression of hoxb4 and hoxb5 in the hindbrain.
Title: Cellular retinoic acid-binding proteins are essential for hindbrain patterning and signal robustness in zebrafish.
crabp2b gene is assigned to zebrafish linkage group 19. Human chromosome 1 has a syntenic relationship to zebrafish linkage groups 16 and 19.
Title: Differential expression of the duplicated cellular retinoic acid-binding protein 2 genes (crabp2a and crabp2b) during zebrafish embryonic development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables retinoic acid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hindbrain morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of retinoic acid receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cellular retinoic acid-binding protein 2b

Names: cellular retinoic acid-binding protein 2b, duplicated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001320394.1 → NP_001307323.1 cellular retinoic acid-binding protein 2b

Status: VALIDATED

Source sequence(s)

CU464180, CU466434

UniProtKB/TrEMBL

A0A8M1P8N3, A4VCG2, Q5G9L7

Related

ENSDARP00000039596.5, ENSDART00000039597.6

Conserved Domains (1) summary

pfam00061
Location:13 → 146

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family