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wars2 tryptophanyl tRNA synthetase 2, mitochondrial [ Danio rerio (zebrafish) ]

Gene ID: 503745, updated on 2-Nov-2024

Summary

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Official Symbol
wars2provided by ZNC
Official Full Name
tryptophanyl tRNA synthetase 2, mitochondrialprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050306-26
See related
Ensembl:ENSDARG00000011801 AllianceGenome:ZFIN:ZDB-GENE-050306-26
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110828
Summary
Predicted to enable tryptophan-tRNA ligase activity. Acts upstream of or within sprouting angiogenesis. Predicted to be active in mitochondrial matrix. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See wars2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (21072291..21117142, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (21261490..21287536, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496517 Neighboring gene T-box transcription factor 15 Neighboring gene si:rp71-68n21.9 Neighboring gene hydroxyacid oxidase 2 (long chain)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Wars2 is a determinant of angiogenesis. Wang M, et al. Nat Commun, 2016 Jul 8. PMID 27389904, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tryptophan-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tryptophanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tryptophanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tryptophan--tRNA ligase, mitochondrial
NP_001013341.1
XP_068079470.1
XP_068079471.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013323.2 → NP_001013341.1  tryptophan--tRNA ligase, mitochondrial

    See identical proteins and their annotated locations for NP_001013341.1

    Status: PROVISIONAL

    Source sequence(s)
    BC090784
    UniProtKB/TrEMBL
    Q5CZN2
    Related
    ENSDARP00000010571.4, ENSDART00000018570.5
    Conserved Domains (2) summary
    cd00806
    Location:42 → 316
    TrpRS_core; catalytic core domain of tryptophanyl-tRNA synthetase
    PRK00927
    Location:39 → 364
    PRK00927; tryptophanyl-tRNA synthetase; Reviewed

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    21072291..21117142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223370.1 → XP_068079471.1  tryptophan--tRNA ligase, mitochondrial isoform X1

  2. XM_068223369.1 → XP_068079470.1  tryptophan--tRNA ligase, mitochondrial isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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