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Rnf10 ring finger protein 10 [ Mus musculus (house mouse) ]

Gene ID: 50849, updated on 9-Dec-2024

Summary

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Official Symbol
Rnf10provided by MGI
Official Full Name
ring finger protein 10provided by MGI
Primary source
MGI:MGI:1859162
See related
Ensembl:ENSMUSG00000041740 AllianceGenome:MGI:1859162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RIE2; mKIAA0262
Summary
The protein encoding this gene is a member of the really interesting new gene finger protein family. Members of this family contain protein motifs similar to zinc finger domains and are involved in many processes that include transcriptional regulation, DNA repair and signal transduction. Expression of this gene is upregulated during neuronal differentiation of cultured cells, and inhibition of its expression impairs differentiation and cell cycle exit, providing evidence for a function in neuronal differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in adrenal adult (RPKM 116.7), testis adult (RPKM 98.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf10 in Genome Data Viewer
Location:
5 F; 5 56.01 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115379829..115410951, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115241770..115272921, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_14109 Neighboring gene predicted gene, 35515 Neighboring gene STARR-seq mESC enhancer starr_14111 Neighboring gene STARR-positive B cell enhancer ABC_E8072 Neighboring gene processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_14112 Neighboring gene STARR-positive B cell enhancer ABC_E3605 Neighboring gene STARR-seq mESC enhancer starr_14114 Neighboring gene coenzyme Q5 methyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E530 Neighboring gene dynein light chain LC8-type 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RING finger protein 10 regulates retinoic acid-induced neuronal differentiation and the cell cycle exit of P19 embryonic carcinoma cells. Malik YS, et al. J Cell Biochem, 2013 Sep. PMID 23526782
  2. cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein. Seki N, et al. J Hum Genet, 2000. PMID 10697961
  3. Characterization of hampin/MSL1 as a node in the nuclear interactome. Dmitriev RI, et al. Biochem Biophys Res Commun, 2007 Apr 20. PMID 17335777, Free PMC Article
  4. Rapid and Integrative Discovery of Retina Regulatory Molecules. Albrecht NE, et al. Cell Rep, 2018 Aug 28. PMID 30157441, Free PMC Article
  5. A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies. Tiu GC, et al. Dev Cell, 2021 Jul 26. PMID 34242585, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0262

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Schwann cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Schwann cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myelination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in postsynapse to nucleus signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in extrinsic component of postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF10
Names
sid 2705
NP_001289377.1
NP_001289378.1
NP_001412439.1
NP_057907.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302448.2 → NP_001289377.1  E3 ubiquitin-protein ligase RNF10 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC145070
    Consensus CDS
    CCDS80381.1
    UniProtKB/TrEMBL
    D3Z1N2, Q3U0W6
    Related
    ENSMUSP00000107726.2, ENSMUST00000112097.8
    Conserved Domains (1) summary
    pfam13923
    Location:225 → 266
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

  2. NM_001302449.2 → NP_001289378.1  E3 ubiquitin-protein ligase RNF10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate in-frame splice sites in the coding region compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC145070
    Consensus CDS
    CCDS80380.1
    UniProtKB/TrEMBL
    H7BX06, Q3U0W6
    Related
    ENSMUSP00000041778.9, ENSMUST00000040555.15
    Conserved Domains (1) summary
    pfam13923
    Location:225 → 266
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

  3. NM_001425510.1 → NP_001412439.1  E3 ubiquitin-protein ligase RNF10 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1. Isoforms 2 and 4 are the same length but have different sequences.
    Source sequence(s)
    AC145070
    UniProtKB/TrEMBL
    Q3U0W6

  4. NM_016698.3 → NP_057907.2  E3 ubiquitin-protein ligase RNF10 isoform 2

    See identical proteins and their annotated locations for NP_057907.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Isoforms 2 and 4 are the same length but have different sequences.
    Source sequence(s)
    AC145070
    Consensus CDS
    CCDS19584.1
    UniProtKB/Swiss-Prot
    Q3UIW5, Q6PDS8, Q6ZQE8, Q91YZ9, Q9R0P0
    UniProtKB/TrEMBL
    Q3U0W6
    Related
    ENSMUSP00000107725.3, ENSMUST00000112096.9
    Conserved Domains (1) summary
    pfam13923
    Location:225 → 266
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115379829..115410951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UIW5.2 GenPept UniProtKB/Swiss-Prot:Q3UIW5

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