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ZNF571 zinc finger protein 571 [ Homo sapiens (human) ]

Gene ID: 51276, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF571provided by HGNC
Official Full Name
zinc finger protein 571provided by HGNC
Primary source
HGNC:HGNC:25000
See related
Ensembl:ENSG00000180479 AllianceGenome:HGNC:25000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC059
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal (RPKM 2.7), testis (RPKM 2.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF571 in Genome Data Viewer
Location:
19q13.12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37564260..37594792, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40366017..40396556, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38055162..38085693, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF793 antisense RNA 1 (head to head) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37996759-37997550 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37997551-37998342 Neighboring gene zinc finger protein 793 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:38020876-38021698 Neighboring gene uncharacterized LOC124904708 Neighboring gene ZNF571 antisense RNA 1 Neighboring gene zinc finger protein 540 Neighboring gene MT-ND4 pseudogene 41 Neighboring gene MT-ND5 pseudogene 45 Neighboring gene MT-CO1 pseudogene 41 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38084654-38085335 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38085336-38086018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14554 Neighboring gene ZFP30 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10556 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38146535-38147522 Neighboring gene zinc finger protein 781

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Zhang QH, et al. Genome Res, 2000 Oct. PMID 11042152, Free PMC Article
  2. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
  3. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. Simpson JC, et al. EMBO Rep, 2000 Sep. PMID 11256614, Free PMC Article
  4. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901, Free PMC Article
  5. From ORFeome to biology: a functional genomics pipeline. Wiemann S, et al. Genome Res, 2004 Oct. PMID 15489336, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16374, MGC138690

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
zinc finger protein 571

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290314.2 → NP_001277243.1  zinc finger protein 571

    See identical proteins and their annotated locations for NP_001277243.1

    Status: VALIDATED

    Source sequence(s)
    AK291413, BC040591, BP312315
    Consensus CDS
    CCDS12505.1
    UniProtKB/Swiss-Prot
    Q2HIY0, Q3ZCU3, Q7Z3V5, Q9NZX7
    Related
    ENSP00000351594.3, ENST00000358744.3
    Conserved Domains (3) summary
    COG5048
    Location:193 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:337 → 357
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 46
    KRAB; KRAB box

  2. NM_001321272.2 → NP_001308201.1  zinc finger protein 571

    Status: VALIDATED

    Source sequence(s)
    AC022148, BC040591
    Consensus CDS
    CCDS12505.1
    UniProtKB/Swiss-Prot
    Q2HIY0, Q3ZCU3, Q7Z3V5, Q9NZX7
    Related
    ENSP00000467572.1, ENST00000593133.5
    Conserved Domains (3) summary
    COG5048
    Location:193 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:337 → 357
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 46
    KRAB; KRAB box

  3. NM_016536.5 → NP_057620.3  zinc finger protein 571

    See identical proteins and their annotated locations for NP_057620.3

    Status: VALIDATED

    Source sequence(s)
    AF161544, BC040591, BP312315
    Consensus CDS
    CCDS12505.1
    UniProtKB/Swiss-Prot
    Q2HIY0, Q3ZCU3, Q7Z3V5, Q9NZX7
    Related
    ENSP00000392638.1, ENST00000451802.7
    Conserved Domains (3) summary
    COG5048
    Location:193 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:337 → 357
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 46
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    37564260..37594792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026858.2 → XP_016882347.1  zinc finger protein 571 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    40366017..40396556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321162.1 → XP_054177137.1  zinc finger protein 571 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z3V5.3 GenPept UniProtKB/Swiss-Prot:Q7Z3V5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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