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GOLM1 golgi membrane protein 1 [ Homo sapiens (human) ]

Gene ID: 51280, updated on 10-Dec-2024

Summary

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Official Symbol
GOLM1provided by HGNC
Official Full Name
golgi membrane protein 1provided by HGNC
Primary source
HGNC:HGNC:15451
See related
Ensembl:ENSG00000135052 MIM:606804; AllianceGenome:HGNC:15451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP73; HEL46; GOLPH2; C9orf155; PSEC0257; bA379P1.3
Summary
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]
Expression
Broad expression in stomach (RPKM 210.4), colon (RPKM 117.5) and 14 other tissues See more
Orthologs
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Genomic context

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See GOLM1 in Genome Data Viewer
Location:
9q21.33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (86026146..86100149, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (98176673..98251783, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88641061..88715064, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal L1 domain-containing protein 1-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19991 Neighboring gene N-alpha-acetyltransferase 35, NatC auxiliary subunit Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88650825-88651760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88677599-88678515 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88679748-88680248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88680249-88681249 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:88693798-88694997 Neighboring gene Sharpr-MPRA regulatory region 3020 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:88713914-88714414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19994 Neighboring gene uncharacterized LOC101927623 Neighboring gene allregulin pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:88761003-88762202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88771625-88772258 Neighboring gene Sharpr-MPRA regulatory region 1717 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:88801905-88802559 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19995 Neighboring gene chromosome 9 open reading frame 153 Neighboring gene RN7SK pseudogene 264

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Causal Association of Golgi Protein 73 With Coronary Artery Disease: Evidence from Proteomics and Mendelian Randomization.
    Title: Causal Association of Golgi Protein 73 With Coronary Artery Disease: Evidence from Proteomics and Mendelian Randomization.
  2. GP73 facilitates hepatitis B virus replication by repressing the NF-kappaB signaling pathway.
    Title: GP73 facilitates hepatitis B virus replication by repressing the NF-κB signaling pathway.
  3. PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1.
    Title: PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1.
  4. Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress.
    Title: Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress.
  5. Novel serum biomarker of Golgi protein 73 for the diagnosis of clinically significant portal hypertension in patients with compensated cirrhosis.
    Title: Novel serum biomarker of Golgi protein 73 for the diagnosis of clinically significant portal hypertension in patients with compensated cirrhosis.
  6. LncRNA ASB16-AS1 accelerates cellular process and chemoresistance of ovarian cancer cells by regulating GOLM1 expression via targeting miR-3918.
    Title: LncRNA ASB16-AS1 accelerates cellular process and chemoresistance of ovarian cancer cells by regulating GOLM1 expression via targeting miR-3918.
  7. GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
    Title: GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
  8. GOLM1 Promotes Epithelial-Mesenchymal Transition by Activating TGFbeta1/Smad2 Signaling in Prostate Cancer.
    Title: GOLM1 Promotes Epithelial-Mesenchymal Transition by Activating TGFβ1/Smad2 Signaling in Prostate Cancer.
  9. GOLM1 facilitates human colorectal cancer progression and metastasis via activating the AKT/GSK3beta/EMT axis.
    Title: GOLM1 facilitates human colorectal cancer progression and metastasis via activating the AKT/GSK3β/EMT axis.
  10. Glypican-3, Vascular Endothelial Growth Factor and Golgi Protein-73 for Differentiation between Liver Cirrhosis and Hepatocellular Carcinoma.
    Title: Glypican-3, Vascular Endothelial Growth Factor and Golgi Protein-73 for Differentiation between Liver Cirrhosis and Hepatocellular Carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (135)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of golgi membrane protein 1 (GOLM1; C9orf155) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22634, FLJ23608

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleus organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in extracellular space HDA PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Golgi membrane protein 1
Names
epididymis luminal protein 46
golgi membrane protein GP73
golgi phosphoprotein 2
golgi protein, 73-kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016548.4 → NP_057632.2  Golgi membrane protein 1

    See identical proteins and their annotated locations for NP_057632.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK027717, AL533767, BC001740
    Consensus CDS
    CCDS35054.1
    UniProtKB/Swiss-Prot
    Q6IAF4, Q8NBJ4, Q9NRB9
    UniProtKB/TrEMBL
    B3KNK9
    Related
    ENSP00000373364.3, ENST00000388712.7
    Conserved Domains (1) summary
    TIGR02169
    Location:41 → 211
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. NM_177937.3 → NP_808800.1  Golgi membrane protein 1

    See identical proteins and their annotated locations for NP_808800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075557, BC001740, DA116177
    Consensus CDS
    CCDS35054.1
    UniProtKB/Swiss-Prot
    Q6IAF4, Q8NBJ4, Q9NRB9
    UniProtKB/TrEMBL
    B3KNK9
    Related
    ENSP00000373363.3, ENST00000388711.7
    Conserved Domains (1) summary
    TIGR02169
    Location:41 → 211
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    86026146..86100149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    98176673..98251783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099268.1: Suppressed sequence

    Description
    NM_001099268.1: This RefSeq was permanently suppressed because it is primarily intronic sequence.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NBJ4.1 GenPept UniProtKB/Swiss-Prot:Q8NBJ4

Gene LinkOut

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