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ACSL5 acyl-CoA synthetase long chain family member 5 [ Homo sapiens (human) ]

Gene ID: 51703, updated on 10-Dec-2024

Summary

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Official Symbol
ACSL5provided by HGNC
Official Full Name
acyl-CoA synthetase long chain family member 5provided by HGNC
Primary source
HGNC:HGNC:16526
See related
Ensembl:ENSG00000197142 MIM:605677; AllianceGenome:HGNC:16526
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACS2; ACS5; FACL5; DIAR13
Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 203.8), duodenum (RPKM 170.4) and 10 other tissues See more
Orthologs
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Genomic context

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See ACSL5 in Genome Data Viewer
Location:
10q25.2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (112374116..112428376)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (113265142..113319056)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (114133874..114188134)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2832 Neighboring gene microRNA 6715b Neighboring gene microRNA 6715a Neighboring gene tectorin beta Neighboring gene guanylate cyclase 2G, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:114135606-114136106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:114136107-114136607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4066 Neighboring gene Sharpr-MPRA regulatory region 13267 Neighboring gene zinc finger DHHC-type palmitoyltransferase 6 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4067 Neighboring gene uncharacterized LOC124902503 Neighboring gene microRNA 4295 Neighboring gene Sharpr-MPRA regulatory region 921 Neighboring gene Sharpr-MPRA regulatory region 3692 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:114492107-114492608 Neighboring gene Sharpr-MPRA regulatory region 7283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:114563987-114564486 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:114570610-114571310 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:114571311-114572009 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:114572010-114572709 Neighboring gene uncharacterized LOC103344931

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ACSL5 genotype influence on fatty acid metabolism: a cellular, tissue, and whole-body study. Rajkumar A, et al. Metabolism, 2018 Jun. PMID 29605434
  2. Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis. Reinartz A, et al. Biochim Biophys Acta, 2010 Sep. PMID 20470896
  3. Functional characterization of a promoter polymorphism that drives ACSL5 gene expression in skeletal muscle and associates with diet-induced weight loss. Teng AC, et al. FASEB J, 2009 Jun. PMID 19218499, Free PMC Article
  4. Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions. Mashima T, et al. Oncogene, 2009 Jan 8. PMID 18806831
  5. High ACSL5 transcript levels associate with systemic lupus erythematosus and apoptosis in Jurkat T lymphocytes and peripheral blood cells. Catalá-Rabasa A, et al. PLoS One, 2011. PMID 22163040, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/beta-catenin signaling by palmitoylation modification.
    Title: ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification.
  2. More than just a histone deacetylase: cytoplasmic SIRT6 facilitates fatty acid oxidation through ACSL5 deacetylation.
    Title: More than just a histone deacetylase: cytoplasmic SIRT6 facilitates fatty acid oxidation through ACSL5 deacetylation.
  3. Hypoxia-responsive PPARGC1A/BAMBI/ACSL5 axis promotes progression and resistance to lenvatinib in hepatocellular carcinoma.
    Title: Hypoxia-responsive PPARGC1A/BAMBI/ACSL5 axis promotes progression and resistance to lenvatinib in hepatocellular carcinoma.
  4. Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long-chain acyl-coenzyme A synthase 5.
    Title: Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long-chain acyl-coenzyme A synthase 5.
  5. The gene variant rs2419621 of ACYL-CoA synthetase long-chain 5 gene is associated with weight loss and metabolic changes in response to a robotic sleeve gastrectomy in morbid obese subjects.
    Title: The gene variant rs2419621 of ACYL-CoA synthetase long-chain 5 gene is associated with weight loss and metabolic changes in response to a robotic sleeve gastrectomy in morbid obese subjects.
  6. Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism.
    Title: Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism.
  7. Deficiency of acyl-CoA synthetase 5 is associated with a severe and treatable failure to thrive of neonatal onset.
    Title: Deficiency of acyl-CoA synthetase 5 is associated with a severe and treatable failure to thrive of neonatal onset.
  8. ACYL-CoA synthetase long-chain 5 polymorphism is associated with weight loss and metabolic changes in response to a partial meal-replacement hypocaloric diet.", trans "El polimorfismo de la ACYL-CoA-sintetasa de cadena larga 5 se asocia a perdida de peso y cambios metabolicos en respuesta a una dieta hipocalorica parcial de reemplazo.
    Title: ACYL-CoA synthetase long-chain 5 polymorphism is associated with weight loss and metabolic changes in response to a partial meal-replacement hypocaloric diet.
  9. A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.
    Title: A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.
  10. ONECUT2 upregulation is associated with CpG hypomethylation at promoter-proximal DNA in gastric cancer and triggers ACSL5.
    Title: ONECUT2 upregulation is associated with CpG hypomethylation at promoter-proximal DNA in gastric cancer and triggers ACSL5.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Diarrhea 13
MedGen: C5830477 OMIM: 620357 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
capsid gag Depletion of the ACSL5 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
  
enables oleoyl-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in positive regulation of long-chain fatty acid import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase 5
Names
FACL5 for fatty acid coenzyme A ligase 5
LACS 5
arachidonate--CoA ligase
fatty acid coenzyme A ligase 5
fatty-acid-Coenzyme A ligase, long-chain 5
long-chain acyl-CoA synthetase 5
long-chain fatty acid coenzyme A ligase 5
NP_001373966.1
NP_057318.2
NP_976313.1
NP_976314.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387037.1 → NP_001373966.1  long-chain-fatty-acid--CoA ligase 5 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL157786
    Consensus CDS
    CCDS91344.1
    UniProtKB/TrEMBL
    A0A8C8KCK5, A0A8C8L3F5
    Related
    ENSP00000403647.2, ENST00000433418.6
    Conserved Domains (1) summary
    cd05927
    Location:157 → 710
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. NM_016234.4 → NP_057318.2  long-chain-fatty-acid--CoA ligase 5 isoform a

    See identical proteins and their annotated locations for NP_057318.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK024932, AL708480, AY358520
    Consensus CDS
    CCDS7572.1
    UniProtKB/TrEMBL
    A0A8C8KCK5
    Related
    ENSP00000348429.1, ENST00000356116.6
    Conserved Domains (2) summary
    PLN02736
    Location:127 → 737
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:157 → 734
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  3. NM_203379.2 → NP_976313.1  long-chain-fatty-acid--CoA ligase 5 isoform b

    See identical proteins and their annotated locations for NP_976313.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. This results in translation initiation from a downstream ATG and an isoform (b) that has a shorter N-terminus compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AK000339, AK024932, AL157786, AY358520, CF595490
    Consensus CDS
    CCDS7573.1
    UniProtKB/Swiss-Prot
    A6GV77, D3DRB3, Q6UX44, Q9UIU4, Q9ULC5
    UniProtKB/TrEMBL
    A0A8C8KCK5
    Related
    ENSP00000346680.4, ENST00000354655.9
    Conserved Domains (1) summary
    cd05927
    Location:101 → 678
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  4. NM_203380.2 → NP_976314.1  long-chain-fatty-acid--CoA ligase 5 isoform b

    See identical proteins and their annotated locations for NP_976314.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. This results in translation initiation from a downstream ATG and an isoform (b) that has a shorter N-terminus compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AK024932, AL708480, AY358520, CD689921
    Consensus CDS
    CCDS7573.1
    UniProtKB/Swiss-Prot
    A6GV77, D3DRB3, Q6UX44, Q9UIU4, Q9ULC5
    UniProtKB/TrEMBL
    A0A8C8KCK5
    Related
    ENSP00000376796.1, ENST00000393081.6
    Conserved Domains (1) summary
    cd05927
    Location:101 → 678
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    112374116..112428376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    113265142..113319056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULC5.1 GenPept UniProtKB/Swiss-Prot:Q9ULC5

Gene LinkOut

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