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Ramp1 receptor (calcitonin) activity modifying protein 1 [ Mus musculus (house mouse) ]

Gene ID: 51801, updated on 2-Jul-2024

Summary

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Official Symbol
Ramp1provided by MGI
Official Full Name
receptor (calcitonin) activity modifying protein 1provided by MGI
Primary source
MGI:MGI:1858418
See related
Ensembl:ENSMUSG00000034353 AllianceGenome:MGI:1858418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130218E19Rik
Summary
Enables coreceptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in extracellular space. Predicted to be part of CGRP receptor complex and amylin receptor complex 1. Predicted to be active in cell surface. Predicted to colocalize with plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; bone; brain; and reproductive system. Orthologous to human RAMP1 (receptor activity modifying protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 23.9), colon adult (RPKM 15.0) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Ramp1 in Genome Data Viewer
Location:
1 D; 1 46.08 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91107544..91152918)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91179822..91225196)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35443 Neighboring gene RNA binding motif protein 44 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93080001-93080198 Neighboring gene proteasome (prosome, macropain) 28 subunit, alpha pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93089975-93090287 Neighboring gene STARR-positive B cell enhancer ABC_E9471 Neighboring gene STARR-positive B cell enhancer ABC_E498 Neighboring gene ubiquitin-conjugating enzyme E2F (putative) Neighboring gene zinc finger protein 330 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Receptor activity-modifying protein 1 regulates mouse skin fibroblast proliferation via the Gαi3-PKA-CREB-YAP axis. Yin S, et al. Cell Commun Signal, 2022 Apr 12. PMID 35413847, Free PMC Article
  2. Inhibition of receptor activity-modifying protein 1 suppresses the development of endometriosis and the formation of blood and lymphatic vessels. Honda M, et al. J Cell Mol Med, 2020 Oct. PMID 32869443, Free PMC Article
  3. RAMP1 signaling in immune cells regulates inflammation-associated lymphangiogenesis. Tsuru S, et al. Lab Invest, 2020 May. PMID 31911634
  4. The neuropeptide receptor subunit RAMP1 constrains the innate immune response during acute pancreatitis in mice. Jochheim LS, et al. Pancreatology, 2019 Jun. PMID 31109903
  5. Receptor activity-modifying protein 1 regulates the phenotypic expression of BMSCs via the Hippo/Yap pathway. Zhang Q, et al. J Cell Physiol, 2019 Aug. PMID 30618207

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRPV1(+) sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling.
    Title: TRPV1(+) sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling.
  2. Receptor activity-modifying protein 1 regulates mouse skin fibroblast proliferation via the Galphai3-PKA-CREB-YAP axis.
    Title: Receptor activity-modifying protein 1 regulates mouse skin fibroblast proliferation via the Gαi3-PKA-CREB-YAP axis.
  3. RAMP1 and RAMP3 Differentially Control Amylin's Effects on Food Intake, Glucose and Energy Balance in Male and Female Mice.
    Title: RAMP1 and RAMP3 Differentially Control Amylin's Effects on Food Intake, Glucose and Energy Balance in Male and Female Mice.
  4. Inhibition of receptor activity-modifying protein 1 suppresses the development of endometriosis and the formation of blood and lymphatic vessels.
    Title: Inhibition of receptor activity-modifying protein 1 suppresses the development of endometriosis and the formation of blood and lymphatic vessels.
  5. The CGRP receptor component RAMP1 links sensory innervation with YAP activity in the regenerating liver.
    Title: The CGRP receptor component RAMP1 links sensory innervation with YAP activity in the regenerating liver.
  6. RAMP1 signaling in immune cells regulates inflammation-associated lymphangiogenesis.
    Title: RAMP1 signaling in immune cells regulates inflammation-associated lymphangiogenesis.
  7. Data suggest the molecular mechanisms of receptor activity-modifying protein 1 (RAMP1) in angiogenesis.
    Title: The influence of receptor activity-modifying protein-1 overexpression on angiogenesis in mouse brain capillary endothelial cells.
  8. CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis.
    Title: CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis.
  9. RAMP1 promotes CGRP-induced osteogenic differentiation of bone marrow mesenchymal stem cells via regulation of the Hippo/Yap pathway.
    Title: Receptor activity-modifying protein 1 regulates the phenotypic expression of BMSCs via the Hippo/Yap pathway.
  10. Mice lacking RAMP1 showed increased inflammation, tissue edema, and pancreas injury particularly in the early phase of acute pancreatitis
    Title: The neuropeptide receptor subunit RAMP1 constrains the innate immune response during acute pancreatitis in mice.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (7)  1 citation

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC38240

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amylin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables calcitonin gene-related peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables calcitonin gene-related peptide receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables coreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables coreceptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in amylin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in calcitonin gene-related peptide receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CGRP receptor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
receptor activity-modifying protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168392.1 → NP_001161864.1  receptor activity-modifying protein 1 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding region compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC102874, BY707433, CB522711
    Consensus CDS
    CCDS48321.1
    UniProtKB/TrEMBL
    A0A087WPC6
    Related
    ENSMUSP00000139720.2, ENSMUST00000188475.7
    Conserved Domains (1) summary
    pfam04901
    Location:37 → 63
    RAMP; Receptor activity modifying family

  2. NM_016894.3 → NP_058590.1  receptor activity-modifying protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_058590.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC102874, AK165238, BY733497
    Consensus CDS
    CCDS15158.1
    UniProtKB/Swiss-Prot
    Q9WTJ5
    UniProtKB/TrEMBL
    Q3TNJ3
    Related
    ENSMUSP00000095253.5, ENSMUST00000097648.6
    Conserved Domains (1) summary
    pfam04901
    Location:38 → 145
    RAMP; Receptor activity modifying family

  3. NM_178401.3 → NP_848488.2  receptor activity-modifying protein 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BY733497, CB522711
    Consensus CDS
    CCDS78648.1
    UniProtKB/TrEMBL
    E9Q915
    Related
    ENSMUSP00000128679.3, ENSMUST00000165855.8
    Conserved Domains (1) summary
    pfam04901
    Location:37 → 63
    RAMP; Receptor activity modifying family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    91107544..91152918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321671.1 → XP_017177160.1  receptor activity-modifying protein 1 isoform X1

    Conserved Domains (1) summary
    pfam04901
    Location:15 → 123
    RAMP; Receptor activity modifying family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTJ5.1 GenPept UniProtKB/Swiss-Prot:Q9WTJ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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