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Ppp6r3 protein phosphatase 6, regulatory subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 52036, updated on 9-Dec-2024

Summary

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Official Symbol
Ppp6r3provided by MGI
Official Full Name
protein phosphatase 6, regulatory subunit 3provided by MGI
Primary source
MGI:MGI:1921807
See related
Ensembl:ENSMUSG00000024908 AllianceGenome:MGI:1921807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sapl; Pp6r3; Ppcs3; Saps3; Pptcs3; mKIAA1558; D19Bwg1430e; D19Ertd703e; 4930528G08Rik; 9130026N02Rik
Summary
Predicted to enable protein phosphatase binding activity and protein phosphatase regulator activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Is expressed in cerebellum Purkinje cell layer; cerebellum granule cell layer; and neocortex. Orthologous to human PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 26.1), thymus adult (RPKM 20.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp6r3 in Genome Data Viewer
Location:
19 A; 19 3.21 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (3504928..3626191, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3454928..3576033, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene testis expressed metallothionein like Neighboring gene galanin and GMAP prepropeptide Neighboring gene STARR-seq mESC enhancer starr_45317 Neighboring gene predicted gene, 23940 Neighboring gene STARR-seq mESC enhancer starr_45318 Neighboring gene STARR-positive B cell enhancer ABC_E401 Neighboring gene UTP3, small subunit processome component, homolog pseudogene Neighboring gene low density lipoprotein receptor-related protein 5 Neighboring gene VISTA enhancer mm1719 Neighboring gene predicted gene, 36672 Neighboring gene predicted gene, 36608

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations. Al-Barghouthi BM, et al. Elife, 2022 Nov 23. PMID 36416764, Free PMC Article
  2. SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice. Yang Y, et al. Nat Commun, 2023 Mar 13. PMID 36914647, Free PMC Article
  3. Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor. Saijoh Y, et al. Genes Cells, 1996 Feb. PMID 9140067
  4. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. Stefansson B, et al. J Biol Chem, 2006 Aug 11. PMID 16769727
  5. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice.
    Title: SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 6 regulatory subunit 3
Names
SAPS domain family, member 3
pluripotent cell-specific 3
sporulation-induced transcript 4-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164159.1 → NP_001157631.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 3

    See identical proteins and their annotated locations for NP_001157631.1

    Status: VALIDATED

    Source sequence(s)
    AK035236, AV456025, BB661794, BP760563, BU612294, BY720838, CF537891, CK619000
    Consensus CDS
    CCDS50340.1
    UniProtKB/Swiss-Prot
    Q922D4
    Related
    ENSMUSP00000131084.2, ENSMUST00000172362.3
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein
    cl00478
    Location:688 → 820
    LGT; Prolipoprotein diacylglyceryl transferase

  2. NM_001360429.1 → NP_001347358.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117797, BP760563
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein
    pfam16001
    Location:624 → 877
    DUF4775; Domain of unknown function (DUF4775)

  3. NM_001360430.1 → NP_001347359.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117797, BP760563
    Consensus CDS
    CCDS50340.1
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein
    cl00478
    Location:688 → 820
    LGT; Prolipoprotein diacylglyceryl transferase

  4. NM_028999.1 → NP_083275.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_083275.1

    Status: VALIDATED

    Source sequence(s)
    AK035236, AV456025, BB661794, BP760563, CF537891, CF727136, CK619000
    Consensus CDS
    CCDS50341.1
    UniProtKB/TrEMBL
    G5E8R4
    Related
    ENSMUSP00000109630.3, ENSMUST00000113997.9
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein
    pfam16001
    Location:624 → 871
    DUF4775; Domain of unknown function (DUF4775)

  5. NM_029456.2 → NP_083732.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_083732.1

    Status: VALIDATED

    Source sequence(s)
    AK035236, AV456025, BB661794, BP760563, CF537891, CK619000
    Consensus CDS
    CCDS29397.1
    UniProtKB/Swiss-Prot
    Q6ZPM9, Q8BTW6, Q922D4, Q9D2X9
    Related
    ENSMUSP00000025846.9, ENSMUST00000025846.16
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    3504928..3626191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318250.3 → XP_017173739.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  2. XM_017318249.3 → XP_017173738.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

    Conserved Domains (2) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein
    pfam16001
    Location:589 → 836
    DUF4775; Domain of unknown function (DUF4775)

  3. XM_006531794.3 → XP_006531857.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X9

    Conserved Domains (2) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein
    pfam16001
    Location:589 → 842
    DUF4775; Domain of unknown function (DUF4775)

  4. XM_017318248.3 → XP_017173737.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

    Conserved Domains (2) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein
    pfam16001
    Location:607 → 854
    DUF4775; Domain of unknown function (DUF4775)

  5. XM_011248641.3 → XP_011246943.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

    Conserved Domains (2) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein
    pfam16001
    Location:607 → 860
    DUF4775; Domain of unknown function (DUF4775)

  6. XM_006531792.3 → XP_006531855.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

    Conserved Domains (2) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein
    pfam16001
    Location:618 → 865
    DUF4775; Domain of unknown function (DUF4775)

  7. XM_011248640.3 → XP_011246942.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3

    Conserved Domains (2) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein
    pfam16001
    Location:618 → 871
    DUF4775; Domain of unknown function (DUF4775)

  8. XM_011248642.4 → XP_011246944.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  9. XM_036161629.1 → XP_036017522.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  10. XM_036161624.1 → XP_036017517.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  11. XM_036161626.1 → XP_036017519.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X8

    UniProtKB/Swiss-Prot
    Q6ZPM9, Q8BTW6, Q922D4, Q9D2X9
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  12. XM_030250988.2 → XP_030106848.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

    UniProtKB/TrEMBL
    G5E8R4
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein
    pfam16001
    Location:624 → 871
    DUF4775; Domain of unknown function (DUF4775)

  13. XM_030250986.2 → XP_030106846.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

    Conserved Domains (2) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein
    pfam16001
    Location:624 → 877
    DUF4775; Domain of unknown function (DUF4775)

  14. XM_030250987.2 → XP_030106847.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

    Conserved Domains (2) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein
    pfam16001
    Location:624 → 877
    DUF4775; Domain of unknown function (DUF4775)

  15. XM_036161627.1 → XP_036017520.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

    Conserved Domains (1) summary
    pfam04499
    Location:117 → 467
    SAPS; SIT4 phosphatase-associated protein

  16. XM_036161625.1 → XP_036017518.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  17. XM_036161628.1 → XP_036017521.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

    Conserved Domains (1) summary
    pfam04499
    Location:117 → 467
    SAPS; SIT4 phosphatase-associated protein

  18. XM_006531797.5 → XP_006531860.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X13

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

RNA

  1. XR_001782603.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922D4.1 GenPept UniProtKB/Swiss-Prot:Q922D4

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