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PFKM phosphofructokinase, muscle [ Homo sapiens (human) ]

Gene ID: 5213, updated on 10-Dec-2024

Summary

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Official Symbol
PFKMprovided by HGNC
Official Full Name
phosphofructokinase, muscleprovided by HGNC
Primary source
HGNC:HGNC:8877
See related
Ensembl:ENSG00000152556 MIM:610681; AllianceGenome:HGNC:8877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSD7; PFK1; PFKA; PFKX; PFK-1; PFK-A; ATP-PFK; PPP1R122
Summary
Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
Expression
Broad expression in heart (RPKM 77.2), brain (RPKM 32.0) and 21 other tissues See more
Orthologs
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Genomic context

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See PFKM in Genome Data Viewer
Location:
12q13.11
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48105353..48146404)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48066690..48107749)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48499136..48540187)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SUMO specific peptidase 1 Neighboring gene V-type proton ATPase subunit F-like Neighboring gene RNA, U6 small nuclear 1203, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr12:48484832-48485048 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48498859-48499734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48499735-48500608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6279 Neighboring gene microRNA 6505 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48536214-48537195 Neighboring gene NANOG hESC enhancer GRCh37_chr12:48551082-48551604 Neighboring gene SCO1 cytochrome c oxidase assembly protein pseudogene Neighboring gene ankyrin repeat and SOCS box containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Differential expression of phosphofructokinase-1 isoforms correlates with the glycolytic efficiency of breast cancer cells. Zancan P, et al. Mol Genet Metab, 2010 Aug. PMID 20483646
  2. Deficiency of phosphofructo-1-kinase/muscle subtype in humans impairs insulin secretion and causes insulin resistance. Ristow M, et al. J Clin Invest, 1997 Dec 1. PMID 9389749, Free PMC Article
  3. Novel missense mutation (W686C) of the phosphofructokinase-M gene in a Japanese patient with a mild form of glycogenosis VII. Hamaguchi T, et al. Hum Mutat, 1996. PMID 8889589
  4. Physical and genetic mapping of the muscle phosphofructokinase gene (PFKM): reassignment to human chromosome 12q. Howard TD, et al. Genomics, 1996 May 15. PMID 8661033
  5. A 5' splice junction mutation leading to exon deletion in an Ashkenazic Jewish family with phosphofructokinase deficiency (Tarui disease). Raben N, et al. J Biol Chem, 1993 Mar 5. PMID 8444874

See all (162) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity.
    Title: Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity.
  2. RNAi screening reveals a synthetic chemical-genetic interaction between ATP synthase and PFK1 in cancer cells.
    Title: RNAi screening reveals a synthetic chemical-genetic interaction between ATP synthase and PFK1 in cancer cells.
  3. Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM.
    Title: Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM.
  4. Association of PFKM gene polymorphisms and susceptibility to cryptorchidism in a Chinese Han population.
    Title: Association of PFKM gene polymorphisms and susceptibility to cryptorchidism in a Chinese Han population.
  5. Expression of HK2, PKM2, and PFKM Is Associated with Metastasis and Late Disease Onset in Breast Cancer Patients.
    Title: Expression of HK2, PKM2, and PFKM Is Associated with Metastasis and Late Disease Onset in Breast Cancer Patients.
  6. RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2.
    Title: RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2.
  7. PFK activation is essential for the odontogenic differentiation of human dental pulp stem cells.
    Title: PFK activation is essential for the odontogenic differentiation of human dental pulp stem cells.
  8. TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas.
    Title: TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas.
  9. ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM.
    Title: ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM.
  10. Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.
    Title: Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Glycogen storage disease, type VII
MedGen: C0017926 OMIM: 232800 GeneReviews: Not available
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EBI GWAS Catalog

Description
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of phosphofructokinase (muscle, PFKM) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC8699

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 6-phosphofructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 6-phosphofructokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 6-phosphofructokinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 6-phosphofructokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables fructose binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables fructose-6-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical glycolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 6-phosphate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fructose 6-phosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolysis from storage polysaccharide through glucose-1-phosphate IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycolytic process through fructose-6-phosphate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle cell cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of 6-phosphofructokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of 6-phosphofructokinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm principal piece IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-dependent 6-phosphofructokinase, muscle type
Names
6-phosphofructo-1-kinase
6-phosphofructokinase type A
6-phosphofructokinase, muscle type
phosphofructo-1-kinase isozyme A
phosphofructokinase 1
phosphofructokinase, polypeptide X
phosphofructokinase-M
phosphohexokinase
protein phosphatase 1, regulatory subunit 122
NP_000280.1
NP_001160158.1
NP_001160159.1
NP_001160160.1
NP_001341664.1
NP_001341665.1
NP_001341666.1
NP_001341667.1
NP_001341668.1
NP_001341669.1
NP_001341670.1
NP_001341671.1
NP_001341672.1
NP_001341673.1
NP_001341674.1
NP_001341675.1
NP_001341676.1
NP_001341677.1
NP_001350548.1
XP_005269031.1
XP_005269033.1
XP_011536789.2
XP_016874958.1
XP_024304788.1
XP_024304789.1
XP_024304790.1
XP_047284955.1
XP_047284956.1
XP_047284957.1
XP_047284958.1
XP_047284959.1
XP_047284960.1
XP_054228244.1
XP_054228245.1
XP_054228246.1
XP_054228247.1
XP_054228248.1
XP_054228249.1
XP_054228250.1
XP_054228251.1
XP_054228252.1
XP_054228253.1
XP_054228254.1
XP_054228255.1
XP_054228256.1
XP_054228257.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016199.2 RefSeqGene

    Range
    19112..46152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1177

mRNA and Protein(s)

  1. NM_000289.6 → NP_000280.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    See identical proteins and their annotated locations for NP_000280.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as type C) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).
    Source sequence(s)
    BC000534, BC021203, BU683561, DA525437
    Consensus CDS
    CCDS8760.1
    UniProtKB/Swiss-Prot
    J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
    UniProtKB/TrEMBL
    A0A024R0Y5, Q96I60
    Related
    ENSP00000352842.5, ENST00000359794.11
    Conserved Domains (1) summary
    cd00764
    Location:13 → 774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  2. NM_001166686.2 → NP_001160158.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

    See identical proteins and their annotated locations for NP_001160158.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) (also known as TE-PFKM) encodes isoform 1. Variants 1, 7, 8, and 9 encode the same isoform (1).
    Source sequence(s)
    BC000534, BC021203, BU683561, DB081387
    Consensus CDS
    CCDS53786.1
    UniProtKB/TrEMBL
    Q96I60
    Related
    ENSP00000345771.6, ENST00000340802.12
    Conserved Domains (1) summary
    cd00764
    Location:84 → 845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  3. NM_001166687.2 → NP_001160159.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    See identical proteins and their annotated locations for NP_001160159.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as type A) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).
    Source sequence(s)
    BC000534, BU683561, DA560355, Y00698
    Consensus CDS
    CCDS8760.1
    UniProtKB/Swiss-Prot
    J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
    UniProtKB/TrEMBL
    A0A024R0Y5, Q96I60
    Related
    ENSP00000309438.7, ENST00000312352.11
    Conserved Domains (1) summary
    cd00764
    Location:13 → 774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  4. NM_001166688.2 → NP_001160160.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    See identical proteins and their annotated locations for NP_001160160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as type B) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).
    Source sequence(s)
    BC000534, BU683561, DA761651
    Consensus CDS
    CCDS8760.1
    UniProtKB/Swiss-Prot
    J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
    UniProtKB/TrEMBL
    A0A024R0Y5, Q96I60
    Related
    ENSP00000449426.1, ENST00000547587.5
    Conserved Domains (1) summary
    cd00764
    Location:13 → 774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  5. NM_001354735.1 → NP_001341664.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS86294.1
    UniProtKB/TrEMBL
    A0A2R8Y891, Q96I60
    Related
    ENSP00000496597.1, ENST00000642730.1
    Conserved Domains (1) summary
    cd00764
    Location:116 → 877
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  6. NM_001354736.1 → NP_001341665.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS86294.1
    UniProtKB/TrEMBL
    A0A2R8Y891, Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:116 → 877
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  7. NM_001354737.1 → NP_001341666.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS53786.1
    UniProtKB/TrEMBL
    Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:84 → 845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  8. NM_001354738.1 → NP_001341667.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS53786.1
    UniProtKB/TrEMBL
    Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:84 → 845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  9. NM_001354739.1 → NP_001341668.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS53786.1
    UniProtKB/TrEMBL
    Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:84 → 845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  10. NM_001354740.1 → NP_001341669.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    UniProtKB/TrEMBL
    Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:61 → 822
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  11. NM_001354741.2 → NP_001341670.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    UniProtKB/TrEMBL
    Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:21 → 782
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  12. NM_001354742.2 → NP_001341671.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS8760.1
    UniProtKB/Swiss-Prot
    J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
    UniProtKB/TrEMBL
    A0A024R0Y5, Q96I60
    Related
    ENSP00000450369.2, ENST00000550345.6
    Conserved Domains (1) summary
    cd00764
    Location:13 → 774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  13. NM_001354743.2 → NP_001341672.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS8760.1
    UniProtKB/Swiss-Prot
    J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
    UniProtKB/TrEMBL
    A0A024R0Y5, Q96I60
    Related
    ENSP00000446945.2, ENST00000550924.6
    Conserved Domains (1) summary
    cd00764
    Location:13 → 774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  14. NM_001354744.2 → NP_001341673.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS8760.1
    UniProtKB/Swiss-Prot
    J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
    UniProtKB/TrEMBL
    A0A024R0Y5, Q96I60
    Related
    ENSP00000448253.2, ENST00000551339.6
    Conserved Domains (1) summary
    cd00764
    Location:13 → 774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  15. NM_001354745.2 → NP_001341674.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    UniProtKB/TrEMBL
    Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:1 → 745
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  16. NM_001354746.2 → NP_001341675.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    UniProtKB/TrEMBL
    Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:13 → 732
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  17. NM_001354747.2 → NP_001341676.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    UniProtKB/TrEMBL
    Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:3 → 724
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  18. NM_001354748.2 → NP_001341677.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    UniProtKB/TrEMBL
    Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:3 → 724
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  19. NM_001363619.2 → NP_001350548.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029, KU178252
    Consensus CDS
    CCDS86295.1
    UniProtKB/TrEMBL
    A0A0S2Z4I1, Q96I60
    Related
    ENSP00000448177.1, ENST00000551804.5
    Conserved Domains (1) summary
    cd00764
    Location:13 → 743
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

RNA

  1. NR_148954.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029, U24183
    Related
    ENST00000546964.5

  2. NR_148955.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029, AK126020
    Related
    ENST00000547581.5

  3. NR_148956.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029

  4. NR_148957.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029

  5. NR_148958.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029

  6. NR_148959.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    48105353..48146404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428999.1 → XP_047284955.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X1

  2. XM_011538487.2 → XP_011536789.2  ATP-dependent 6-phosphofructokinase, muscle type isoform X2

    UniProtKB/TrEMBL
    Q96I60

  3. XM_047429000.1 → XP_047284956.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X3

    UniProtKB/TrEMBL
    Q96I60

  4. XM_005268976.4 → XP_005269033.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X5

    See identical proteins and their annotated locations for XP_005269033.1

    UniProtKB/TrEMBL
    A0A2R8Y891, Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:116 → 877
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  5. XM_047429001.1 → XP_047284957.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X4

    UniProtKB/TrEMBL
    Q96I60

  6. XM_024449020.2 → XP_024304788.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X6

    UniProtKB/TrEMBL
    F8VTQ3, Q96I60
    Related
    ENSP00000447997.3, ENST00000550257.7
    Conserved Domains (1) summary
    cd00764
    Location:87 → 848
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  7. XM_047429002.1 → XP_047284958.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X7

    UniProtKB/TrEMBL
    Q96I60

  8. XM_024449021.2 → XP_024304789.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X9

    UniProtKB/TrEMBL
    Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:46 → 807
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  9. XM_047429004.1 → XP_047284960.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X11

    UniProtKB/TrEMBL
    Q96I60
    Related
    ENSP00000446829.3, ENST00000549941.7

  10. XM_017019469.2 → XP_016874958.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X8

    UniProtKB/TrEMBL
    Q96I60

  11. XM_005268974.2 → XP_005269031.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X5

    See identical proteins and their annotated locations for XP_005269031.1

    UniProtKB/TrEMBL
    A0A2R8Y891, Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:116 → 877
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  12. XM_047429003.1 → XP_047284959.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X10

    UniProtKB/TrEMBL
    Q96I60

  13. XM_024449022.2 → XP_024304790.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X12

    UniProtKB/Swiss-Prot
    J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
    UniProtKB/TrEMBL
    A0A024R0Y5, Q96I60
    Conserved Domains (1) summary
    cd00764
    Location:13 → 774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    48066690..48107749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372275.1 → XP_054228250.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X14

    UniProtKB/TrEMBL
    Q96I60

  2. XM_054372271.1 → XP_054228246.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X5

    UniProtKB/TrEMBL
    Q96I60

  3. XM_054372269.1 → XP_054228244.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X4

    UniProtKB/TrEMBL
    Q96I60

  4. XM_054372272.1 → XP_054228247.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X13

    UniProtKB/TrEMBL
    Q96I60

  5. XM_054372273.1 → XP_054228248.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X6

    UniProtKB/TrEMBL
    F8VTQ3, Q96I60

  6. XM_054372276.1 → XP_054228251.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X7

    UniProtKB/TrEMBL
    Q96I60

  7. XM_054372279.1 → XP_054228254.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X9

    UniProtKB/TrEMBL
    Q96I60

  8. XM_054372281.1 → XP_054228256.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X11

    UniProtKB/TrEMBL
    Q96I60

  9. XM_054372277.1 → XP_054228252.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X8

    UniProtKB/TrEMBL
    Q96I60

  10. XM_054372270.1 → XP_054228245.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X5

    UniProtKB/TrEMBL
    Q96I60

  11. XM_054372274.1 → XP_054228249.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X14

    UniProtKB/TrEMBL
    Q96I60

  12. XM_054372278.1 → XP_054228253.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X8

    UniProtKB/TrEMBL
    Q96I60

  13. XM_054372280.1 → XP_054228255.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X10

    UniProtKB/TrEMBL
    Q96I60

  14. XM_054372282.1 → XP_054228257.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X12

    UniProtKB/Swiss-Prot
    J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
    UniProtKB/TrEMBL
    A0A024R0Y5, Q96I60
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08237.2 GenPept UniProtKB/Swiss-Prot:P08237

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