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PGGT1B protein geranylgeranyltransferase type I subunit beta [ Homo sapiens (human) ]

Gene ID: 5229, updated on 10-Dec-2024

Summary

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Official Symbol
PGGT1Bprovided by HGNC
Official Full Name
protein geranylgeranyltransferase type I subunit betaprovided by HGNC
Primary source
HGNC:HGNC:8895
See related
Ensembl:ENSG00000164219 MIM:602031; AllianceGenome:HGNC:8895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BGGI; GGTI
Summary
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]
Expression
Ubiquitous expression in colon (RPKM 3.0), spleen (RPKM 2.3) and 25 other tissues See more
Orthologs
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Genomic context

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See PGGT1B in Genome Data Viewer
Location:
5q22.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (115204012..115262877, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (115713562..115776201, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (114539709..114598574, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927078 Neighboring gene long intergenic non-protein coding RNA 1957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:114117551-114118374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:114118375-114119196 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114364005-114364746 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114364747-114365486 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:114368052-114369251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22923 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:114404076-114405275 Neighboring gene Sharpr-MPRA regulatory region 9285 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114426721-114427222 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114426221-114426720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22925 Neighboring gene tripartite motif containing 36 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22927 Neighboring gene ribosomal protein S2 pseudogene 26 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 15 Neighboring gene coiled-coil domain containing 112

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor. Kusama T, et al. Clin Exp Metastasis, 2003. PMID 14598891
  2. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. Virtanen SS, et al. Cell Biol Int, 2010 Aug. PMID 20446922
  3. The diagnostic significance of PGGT1B in psoriasis. Hao Z, et al. Dermatol Ther, 2021 Mar. PMID 33548109
  4. Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle. Ghavami S, et al. Am J Physiol Lung Cell Mol Physiol, 2012 Feb 15. PMID 22160308
  5. Geranylgeranyltransferase I regulates HIF-1α promoting glioblastoma cell migration and invasion. Zhou X, et al. J Neurooncol, 2013 May. PMID 23475391

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The diagnostic significance of PGGT1B in psoriasis.
    Title: The diagnostic significance of PGGT1B in psoriasis.
  2. our study showed, for the first time, that HIF-1alpha was regulated by protein prenylation transferase GGTI and mediated the effect of GGTI on glioma cell migration and invasion
    Title: Geranylgeranyltransferase I regulates HIF-1α promoting glioblastoma cell migration and invasion.
  3. our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability
    Title: Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.
  4. RNAi knockdown of GGTase-Ibeta inhibited invasion, disrupted F-actin organization and decreased the level of cofilin in PC-3 cells.
    Title: Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells.
  5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
  6. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.
  7. results suggest that geranylgeranylation of RhoA is critical for cancer cell invasion
    Title: Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor.
  8. Results suggest that all peptide substrates adopt a common binding mode in the protein farnesyltransferase and geranylgeranyltransferase active site.
    Title: Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat FITC-labeled Tat 47-59 peptide downregulates gene expression of protein geranylgeranyltransferase type I, beta subunit (PGGT1B) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to CAAX-protein geranylgeranyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CAAX-protein geranylgeranyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein geranylgeranyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein geranylgeranylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of CAAX-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CAAX-protein geranylgeranyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of CAAX-protein geranylgeranyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
geranylgeranyl transferase type-1 subunit beta
Names
CTC-428G20.3
GGTase-I-beta
geranylgeranyl transferase type I subunit beta
geranylgeranyltransferase type I beta subunit
protein geranylgeranyltransferase type I, beta subunit
type I protein geranyl-geranyltransferase subunit beta
NP_005014.2
XP_005272077.2
XP_011541792.1
XP_047273270.1
XP_054208798.1
XP_054208799.1
XP_054208800.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005023.4 → NP_005014.2  geranylgeranyl transferase type-1 subunit beta

    See identical proteins and their annotated locations for NP_005014.2

    Status: VALIDATED

    Source sequence(s)
    AC008494, AL520655, AW382606, DA024020
    Consensus CDS
    CCDS4116.1
    UniProtKB/Swiss-Prot
    P53609, Q5MJP9
    Related
    ENSP00000404676.1, ENST00000419445.6
    Conserved Domains (1) summary
    cd02895
    Location:22 → 332
    GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    115204012..115262877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543490.3 → XP_011541792.1  geranylgeranyl transferase type-1 subunit beta isoform X1

    Conserved Domains (1) summary
    cd02895
    Location:22 → 332
    GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...

  2. XM_005272020.4 → XP_005272077.2  geranylgeranyl transferase type-1 subunit beta isoform X2

    See identical proteins and their annotated locations for XP_005272077.2

    Conserved Domains (1) summary
    cd02895
    Location:22 → 332
    GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...

  3. XM_047417314.1 → XP_047273270.1  geranylgeranyl transferase type-1 subunit beta isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    115713562..115776201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352823.1 → XP_054208798.1  geranylgeranyl transferase type-1 subunit beta isoform X1

  2. XM_054352824.1 → XP_054208799.1  geranylgeranyl transferase type-1 subunit beta isoform X2

  3. XM_054352825.1 → XP_054208800.1  geranylgeranyl transferase type-1 subunit beta isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53609.2 GenPept UniProtKB/Swiss-Prot:P53609

Gene LinkOut

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