Wipi1 WD repeat domain, phosphoinositide interacting 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wipi1provided by MGI
Official Full Name: WD repeat domain, phosphoinositide interacting 1provided by MGI
Primary source: MGI:MGI:1261864
See related: Ensembl:ENSMUSG00000041895 AllianceGenome:MGI:1261864
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D11Ertd498e; 4930533H01Rik
Summary: Predicted to enable several functions, including nuclear receptor binding activity; phosphatidylinositol phosphate binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including macroautophagy; positive regulation of autophagosome assembly; and vesicle targeting, trans-Golgi to endosome. Located in phagophore assembly site. Is expressed in several structures, including central nervous system and retina. Orthologous to human WIPI1 (WD repeat domain, phosphoinositide interacting 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 28.8), subcutaneous fat pad adult (RPKM 20.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 72.18 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (109464347..109502215, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (109573521..109611389, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WIPI1 is a conserved mediator of right ventricular failure.
Title: WIPI1 is a conserved mediator of right ventricular failure.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MDB0490 (e-PCR)
- UniSTS:125021

AW411817 (e-PCR)
- UniSTS:180358

AU021843 (e-PCR)
- UniSTS:167057

AI846872 (e-PCR)
- UniSTS:165808

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear androgen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein lipidation involved in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle targeting, trans-Golgi to endosome	IEA Inferred from Electronic Annotation more info
involved_in vesicle targeting, trans-Golgi to endosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site	ISO Inferred from Sequence Orthology more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: WD repeat domain phosphoinositide-interacting protein 1

Names: WD40 repeat protein Interacting with phosphoInositides of 49kDa; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WIPI 49 kDa; WIPI-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145940.2 → NP_666052.1 WD repeat domain phosphoinositide-interacting protein 1

See identical proteins and their annotated locations for NP_666052.1

Status: PROVISIONAL

Source sequence(s)

AL645791, AL732387

Consensus CDS

CCDS25582.1

UniProtKB/Swiss-Prot

Q8BGE1, Q8R1A9, Q8R1C7, Q8R3E3

Related

ENSMUSP00000099349.4, ENSMUST00000103060.10

Conserved Domains (3) summary

COG2319
Location:100 → 265

WD40; WD40 repeat [General function prediction only]

sd00039
Location:144 → 184

7WD40; WD40 repeat [structural motif]

cl02567
Location:88 → 262

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...