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Mettl2 methyltransferase 2, methylcytidine [ Mus musculus (house mouse) ]

Gene ID: 52686, updated on 9-May-2024

Summary

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Official Symbol
Mettl2provided by MGI
Official Full Name
methyltransferase 2, methylcytidineprovided by MGI
Primary source
MGI:MGI:1289171
See related
Ensembl:ENSMUSG00000020691 AllianceGenome:MGI:1289171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
METL; PSENIP1; D11Ertd768e; 2810438F06Rik; C130031G21Rik
Summary
Enables tRNA (cytosine-3-)-methyltransferase activity. Involved in tRNA methylation. Is expressed in several structures, including alimentary system; central nervous system; heart; respiratory system; and sensory organ. Orthologous to several human genes including METTL2A (methyltransferase 2A, methylcytidine). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.6), limb E14.5 (RPKM 6.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mettl2 in Genome Data Viewer
Location:
11 E1; 11 68.61 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105017251..105031972)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105126425..105141146)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 3 Neighboring gene STARR-seq mESC enhancer starr_30901 Neighboring gene microtubule-associated protein pseudogene Neighboring gene predicted gene, 25362 Neighboring gene STARR-positive B cell enhancer ABC_E7076 Neighboring gene RIKEN cDNA 1700052K11 gene Neighboring gene STARR-positive B cell enhancer ABC_E8463 Neighboring gene predicted gene 11620 Neighboring gene tousled-like kinase 2 (Arabidopsis)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans. Xu L, et al. J Biol Chem, 2017 Sep 1. PMID 28655767, Free PMC Article
  2. Unravelling the complex genetics of cleft lip in the mouse model. Juriloff DM, et al. Mamm Genome, 2001 Jun. PMID 11353389
  3. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
  4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Gene trapped (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC107608

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (cytidine) methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA (cytidine-3-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA (cytidine-3-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tRNA (cytidine-3-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA N(3)-methylcytidine methyltransferase METTL2
Names
methyltransferase like 2
methyltransferase-like protein 2
NP_766155.3
XP_006533777.1
XP_006533778.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172567.3 → NP_766155.3  tRNA N(3)-methylcytidine methyltransferase METTL2

    See identical proteins and their annotated locations for NP_766155.3

    Status: VALIDATED

    Source sequence(s)
    AK048040, AL627235, BB671561
    Consensus CDS
    CCDS25538.1
    UniProtKB/Swiss-Prot
    Q3U5T7, Q5EBH8, Q8BMK1, Q8BXC2
    Related
    ENSMUSP00000021030.8, ENSMUST00000021030.8
    Conserved Domains (1) summary
    pfam08242
    Location:178 → 280
    Methyltransf_12; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    105017251..105031972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533714.2 → XP_006533777.1  tRNA N(3)-methylcytidine methyltransferase METTL2 isoform X1

    Conserved Domains (1) summary
    pfam08242
    Location:178 → 280
    Methyltransf_12; Methyltransferase domain

  2. XM_006533715.3 → XP_006533778.1  tRNA N(3)-methylcytidine methyltransferase METTL2 isoform X2

    Conserved Domains (1) summary
    pfam08242
    Location:178 → 280
    Methyltransf_12; Methyltransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMK1.2 GenPept UniProtKB/Swiss-Prot:Q8BMK1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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