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PLCB2 phospholipase C beta 2 [ Homo sapiens (human) ]

Gene ID: 5330, updated on 2-Nov-2024

Summary

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Official Symbol
PLCB2provided by HGNC
Official Full Name
phospholipase C beta 2provided by HGNC
Primary source
HGNC:HGNC:9055
See related
Ensembl:ENSG00000137841 MIM:604114; AllianceGenome:HGNC:9055
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLC-beta-2
Summary
The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017]
Expression
Broad expression in spleen (RPKM 26.9), bone marrow (RPKM 19.8) and 17 other tissues See more
Orthologs
mouse all
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Genomic context

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See PLCB2 in Genome Data Viewer
Location:
15q15.1
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40284256..40307935, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (38091173..38114815, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40580110..40600136, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene BUB1B-PAK6 readthrough Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9238 Neighboring gene PAK6 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40548820-40549617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40564915-40565416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40566138-40566638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40572232-40573016 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6322 Neighboring gene ankyrin repeat domain 63 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40583508-40584053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40584054-40584598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9239 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40594309-40595118 Neighboring gene uncharacterized LOC112268152 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:40602266-40602469 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 10 Neighboring gene NANOG hESC enhancer GRCh37_chr15:40613053-40613570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6324 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6325 Neighboring gene InaF motif containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Selective up-regulation of phospholipase C-beta2 during granulocytic differentiation of normal and leukemic hematopoietic progenitors. Bertagnolo V, et al. J Leukoc Biol, 2002 Jun. PMID 12050180
  2. Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptor. Darè E, et al. J Mol Endocrinol, 1998 Aug. PMID 9723859
  3. Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization. Park SH, et al. Cytogenet Cell Genet, 1998. PMID 9925923
  4. Alternative splice variants of phospholipase C-beta2 are expressed in platelets: effect on Galphaq-dependent activation and localization. Sun L, et al. Platelets, 2007 May. PMID 17497434
  5. PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors. Brugnoli F, et al. Cell Signal, 2007 Aug. PMID 17478077

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLCbeta2 Promotes VEGF-Induced Vascular Permeability.
    Title: PLCβ2 Promotes VEGF-Induced Vascular Permeability.
  2. Knockdown of PLCB2 expression reduces melanoma cell viability and promotes melanoma cell apoptosis by altering Ras/Raf/MAPK signals.
    Title: Knockdown of PLCB2 expression reduces melanoma cell viability and promotes melanoma cell apoptosis by altering Ras/Raf/MAPK signals.
  3. High PLCB2 expression is associated with breast cancer.
    Title: Ectopic expression of PLC-β2 in non-invasive breast tumor cells plays a protective role against malignant progression and is correlated with the deregulation of miR-146a.
  4. this work adds substantial information about the role of PLC-beta2 in invasive breast tumors, demonstrating that its up-regulation in cells with a basal-B triple-negative phenotype is sufficient to down-modulate the expression of surface antigens crucial for malignancy and to reduce the number of cells with a stem-like phenotype.
    Title: Up-modulation of PLC-β2 reduces the number and malignancy of triple-negative breast tumor cells with a CD133(+)/EpCAM(+) phenotype: a promising target for preventing progression of TNBC.
  5. Hypoxia modulates the expression of PLC-beta-2 in breast tumor cells in a phenotype-related manner, since a decrease of the protein was observed in the BT-474 and MCF7 cell lines while an increase was revealed in MDA-MB-231 cells as a consequence of low oxygen availability.
    Title: PLC-β2 is modulated by low oxygen availability in breast tumor cells and plays a phenotype dependent role in their hypoxia-related malignant potential.
  6. Gnb isoforms control a signaling pathway comprising Rac1, Plcbeta2, and Plcbeta3 leading to LFA-1 activation and neutrophil arrest in vivo
    Title: Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo.
  7. Neuropeptide Y decreased PLCB2 expression in HUVECs.
    Title: Neuropeptide Y reduces the expression of PLCB2, PLCD1 and selected PLC genes in cultured human endothelial cells.
  8. high expression of CD133 in triple-negative breast cancer (TNBC)-derived cells correlates with high invasive potential; aggressive properties of CD133high cells are mitigated by PLC-beta2 which down-modulates expression of CD133 and may play a role in preventing metastatic progression of CD133 positive TNBC
    Title: In triple negative breast tumor cells, PLC-β2 promotes the conversion of CD133high to CD133low phenotype and reduces the CD133-related invasiveness.
  9. WDR26 functions as a scaffolding protein to promote PLCbeta2 membrane translocation and interaction with Gbetagamma, thereby enhancing PLCbeta2 activation in leukocytes.
    Title: WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes.
  10. In this study, we show that staphylococcal enterotoxin B activates a Galphaq and PLCbeta2-dependent pathway in human T cells
    Title: Superantigen-induced steroid resistance depends on activation of phospholipase Cβ2.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Genome-wide association study identifies five new schizophrenia loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env PLC-beta activation and intracellular Ca2+ release are required for HIV-1 mediated Rac-1 activation and membrane fusion via the G-alpha(q/11) family of G proteins PubMed
env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed
tat HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity TAS
Traceable Author Statement
more info
  
enables phospholipase C activity TAS
Traceable Author Statement
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in detection of chemical stimulus involved in sensory perception of bitter taste IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of G-protein beta/gamma-subunit complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in neuronal dense core vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Names
phosphoinositide phospholipase C-beta-2
NP_001271226.1
NP_001271227.1
NP_001271228.1
NP_004564.2
XP_016877803.1
XP_016877806.1
XP_016877808.1
XP_047288623.1
XP_047288624.1
XP_047288625.1
XP_047288626.1
XP_047288627.1
XP_047288628.1
XP_047288629.1
XP_047288630.1
XP_047288631.1
XP_047288632.1
XP_047288633.1
XP_047288634.1
XP_047288635.1
XP_047288636.1
XP_047288637.1
XP_047288638.1
XP_047288639.1
XP_047288640.1
XP_047288641.1
XP_047288642.1
XP_047288643.1
XP_047288644.1
XP_047288645.1
XP_054234164.1
XP_054234165.1
XP_054234166.1
XP_054234167.1
XP_054234168.1
XP_054234169.1
XP_054234170.1
XP_054234171.1
XP_054234172.1
XP_054234173.1
XP_054234174.1
XP_054234175.1
XP_054234176.1
XP_054234177.1
XP_054234178.1
XP_054234179.1
XP_054234180.1
XP_054234181.1
XP_054234182.1
XP_054234183.1
XP_054234184.1
XP_054234185.1
XP_054234186.1
XP_054234187.1
XP_054234188.1
XP_054234189.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052867.1 RefSeqGene

    Range
    5039..25065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001284297.2 → NP_001271226.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 2

    See identical proteins and their annotated locations for NP_001271226.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB209583, DA981116, M95678
    Consensus CDS
    CCDS61592.1
    UniProtKB/Swiss-Prot
    Q00722
    UniProtKB/TrEMBL
    Q59F77
    Related
    ENSP00000453975.1, ENST00000557821.5
    Conserved Domains (8) summary
    cd00275
    Location:677 → 798
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 645
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    PLN02228
    Location:217 → 782
    PLN02228; Phosphoinositide phospholipase C
    cd13361
    Location:17 → 144
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam08703
    Location:974 → 1149
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:220 → 311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd16269
    Location:1100 → 1110
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:990 → 1119
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_001284298.2 → NP_001271227.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 3

    See identical proteins and their annotated locations for NP_001271227.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AB209583, BC136467, DA981116
    Consensus CDS
    CCDS61591.1
    UniProtKB/Swiss-Prot
    Q00722
    UniProtKB/TrEMBL
    Q59F77
    Related
    ENSP00000411991.2, ENST00000456256.6
    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam17787
    Location:12 → 141
    PH_14; PH domain
    pfam08703
    Location:963 → 1138
    PLC-beta_C; PLC-beta C terminal

  3. NM_001284299.2 → NP_001271228.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 4

    See identical proteins and their annotated locations for NP_001271228.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC020658, BC009009, DA981116
    Consensus CDS
    CCDS73704.1
    UniProtKB/TrEMBL
    Q9BVT6
    Related
    ENSP00000444652.2, ENST00000543785.3
    Conserved Domains (1) summary
    cd13361
    Location:17 → 144
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

  4. NM_004573.3 → NP_004564.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 1

    See identical proteins and their annotated locations for NP_004564.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB209583, BU147302, DA981116, M95678
    Consensus CDS
    CCDS42020.1
    UniProtKB/Swiss-Prot
    A8K6J2, B9EGH5, Q00722
    Related
    ENSP00000260402.3, ENST00000260402.8
    Conserved Domains (8) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    PLN02228
    Location:217 → 786
    PLN02228; Phosphoinositide phospholipase C
    cd13361
    Location:17 → 144
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam08703
    Location:978 → 1153
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:220 → 311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd16269
    Location:1104 → 1114
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:994 → 1123
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    40284256..40307935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432684.1 → XP_047288640.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X21

  2. XM_047432682.1 → XP_047288638.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X19

  3. XM_047432680.1 → XP_047288636.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X17

  4. XM_047432679.1 → XP_047288635.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X15

  5. XM_047432686.1 → XP_047288642.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X23

  6. XM_047432685.1 → XP_047288641.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X22

  7. XM_047432681.1 → XP_047288637.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X18

  8. XM_047432683.1 → XP_047288639.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X20

  9. XM_017022319.3 → XP_016877808.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X16

  10. XM_047432678.1 → XP_047288634.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X14

  11. XM_047432677.1 → XP_047288633.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X13

  12. XM_047432675.1 → XP_047288631.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X11

  13. XM_047432672.1 → XP_047288628.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X8

  14. XM_047432668.1 → XP_047288624.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

  15. XM_047432676.1 → XP_047288632.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X12

  16. XM_047432673.1 → XP_047288629.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X9

  17. XM_047432670.1 → XP_047288626.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X6

  18. XM_047432669.1 → XP_047288625.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5

  19. XM_047432674.1 → XP_047288630.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X10

  20. XM_047432671.1 → XP_047288627.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X7

  21. XM_047432667.1 → XP_047288623.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

  22. XM_017022317.3 → XP_016877806.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

  23. XM_017022314.3 → XP_016877803.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

  24. XM_047432687.1 → XP_047288643.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X24

  25. XM_047432688.1 → XP_047288644.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X25

  26. XM_047432689.1 → XP_047288645.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X26

RNA

  1. XR_007064458.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    38091173..38114815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378209.1 → XP_054234184.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X21

  2. XM_054378207.1 → XP_054234182.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X19

  3. XM_054378205.1 → XP_054234180.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X17

  4. XM_054378203.1 → XP_054234178.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X15

  5. XM_054378211.1 → XP_054234186.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X23

  6. XM_054378210.1 → XP_054234185.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X22

  7. XM_054378206.1 → XP_054234181.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X18

  8. XM_054378208.1 → XP_054234183.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X20

  9. XM_054378204.1 → XP_054234179.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X16

  10. XM_054378202.1 → XP_054234177.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X14

  11. XM_054378201.1 → XP_054234176.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X13

  12. XM_054378199.1 → XP_054234174.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X11

  13. XM_054378196.1 → XP_054234171.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X8

  14. XM_054378191.1 → XP_054234166.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

  15. XM_054378200.1 → XP_054234175.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X12

  16. XM_054378197.1 → XP_054234172.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X9

  17. XM_054378194.1 → XP_054234169.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X6

  18. XM_054378193.1 → XP_054234168.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5

  19. XM_054378198.1 → XP_054234173.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X10

  20. XM_054378195.1 → XP_054234170.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X7

  21. XM_054378190.1 → XP_054234165.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

  22. XM_054378192.1 → XP_054234167.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

  23. XM_054378189.1 → XP_054234164.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

  24. XM_054378212.1 → XP_054234187.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X24

  25. XM_054378213.1 → XP_054234188.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X25

  26. XM_054378214.1 → XP_054234189.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X26

RNA

  1. XR_008488966.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00722.2 GenPept UniProtKB/Swiss-Prot:Q00722

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