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GPR84 G protein-coupled receptor 84 [ Homo sapiens (human) ]

Gene ID: 53831, updated on 10-Dec-2024

Summary

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Official Symbol
GPR84provided by HGNC
Official Full Name
G protein-coupled receptor 84provided by HGNC
Primary source
HGNC:HGNC:4535
See related
Ensembl:ENSG00000139572 MIM:606383; AllianceGenome:HGNC:4535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EX33; GPCR4
Summary
Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Part of receptor complex. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in bone marrow (RPKM 5.7), appendix (RPKM 3.3) and 6 other tissues See more
Orthologs
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Genomic context

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See GPR84 in Genome Data Viewer
Location:
12q13.13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (54350698..54364486, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (54317281..54331118, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54756229..54758270, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene COPI coat complex subunit zeta 1 Neighboring gene microRNA 148b Neighboring gene RNA, 7SL, cytoplasmic 744, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:54750728-54751553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:54751554-54752378 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:54752379-54753203 Neighboring gene GPR84, ZNF385A, ITGA5 and GTSF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6441 Neighboring gene zinc finger protein 385A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:54781074-54781708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:54781709-54782342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4529 Neighboring gene integrin subunit alpha 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54805235-54806017 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54806018-54806799

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. GPR84 in physiology-Many functions in many tissues. Aktar R, et al. Br J Pharmacol, 2024 May. PMID 37533166
  2. GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis. Dietrich PA, et al. Blood, 2014 Nov 20. PMID 25293777
  3. Mutation analysis and molecular modeling for the investigation of ligand-binding modes of GPR84. Nikaido Y, et al. J Biochem, 2015 May. PMID 25425658
  4. Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression. Müller MM, et al. Sci Rep, 2017 Apr 12. PMID 28404994, Free PMC Article
  5. 20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor? Luscombe VB, et al. DNA Cell Biol, 2020 Nov. PMID 33001759

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR84 in physiology-Many functions in many tissues.
    Title: GPR84 in physiology-Many functions in many tissues.
  2. Regulation of the pro-inflammatory G protein-coupled receptor GPR84.
    Title: Regulation of the pro-inflammatory G protein-coupled receptor GPR84.
  3. Function and regulation of GPR84 in human neutrophils.
    Title: Function and regulation of GPR84 in human neutrophils.
  4. Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84.
    Title: Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84.
  5. Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells.
    Title: Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells.
  6. Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.
    Title: Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.
  7. The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity.
    Title: The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity.
  8. Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84.
    Title: Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84.
  9. 20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor?
    Title: 20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor?
  10. Has a strong stimulatory effect on the expression of cytokine and chemokine genes, particularly CSF3, and on the expression of GPR84, a pro-inflammatory fatty acid receptor.
    Title: IL-33 stimulates expression of the GPR84 (EX33) fatty acid receptor gene and of cytokine and chemokine genes in human adipocytes.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables urotensin II receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in specific granule membrane TAS
Traceable Author Statement
more info
  
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 84
Names
inflammation-related G protein-coupled receptor EX33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020370.3 → NP_065103.1  G-protein coupled receptor 84

    See identical proteins and their annotated locations for NP_065103.1

    Status: VALIDATED

    Source sequence(s)
    BC020614, BP303386, CD366881
    Consensus CDS
    CCDS8878.1
    UniProtKB/Swiss-Prot
    B6V9G7, Q9NQS5
    UniProtKB/TrEMBL
    A8K2X9
    Related
    ENSP00000267015.3, ENST00000267015.4
    Conserved Domains (1) summary
    cd15210
    Location:21 → 381
    7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    54350698..54364486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429017.1 → XP_047284973.1  G-protein coupled receptor 84 isoform X2

    UniProtKB/TrEMBL
    A8K2X9

  2. XM_011538495.3 → XP_011536797.1  G-protein coupled receptor 84 isoform X1

    See identical proteins and their annotated locations for XP_011536797.1

    UniProtKB/Swiss-Prot
    B6V9G7, Q9NQS5
    UniProtKB/TrEMBL
    A8K2X9
    Conserved Domains (1) summary
    cd15210
    Location:21 → 381
    7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    54317281..54331118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372309.1 → XP_054228284.1  G-protein coupled receptor 84 isoform X2

    UniProtKB/TrEMBL
    A8K2X9

  2. XM_054372308.1 → XP_054228283.1  G-protein coupled receptor 84 isoform X1

    UniProtKB/Swiss-Prot
    B6V9G7, Q9NQS5
    UniProtKB/TrEMBL
    A8K2X9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NQS5.1 GenPept UniProtKB/Swiss-Prot:Q9NQS5

Gene LinkOut

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