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man2b1 mannosidase, alpha, class 2B, member 1 [ Danio rerio (zebrafish) ]

Gene ID: 541519, updated on 4-Jan-2025

Summary

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Official Symbol
man2b1provided by ZNC
Official Full Name
mannosidase, alpha, class 2B, member 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050327-52
See related
Ensembl:ENSDARG00000001897 AllianceGenome:ZFIN:ZDB-GENE-050327-52
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110815
Summary
Predicted to enable alpha-mannosidase activity; carbohydrate binding activity; and metal ion binding activity. Predicted to act upstream of or within mannose metabolic process. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See man2b1 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (31258109..31276064, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (30995080..31013019, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene syntaxin 10 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing b Neighboring gene tRNA methyltransferase 1 Neighboring gene si:dkey-238i5.2 Neighboring gene signal-induced proliferation-associated 1 like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Varshney GK, et al. Genome Res, 2015 Jul. PMID 26048245, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysosomal alpha-mannosidase
NP_001014354.1
XP_005169420.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014332.1 → NP_001014354.1  lysosomal alpha-mannosidase precursor

    See identical proteins and their annotated locations for NP_001014354.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091843
    UniProtKB/TrEMBL
    Q58EM3
    Related
    ENSDARP00000014955.8, ENSDART00000004780.10
    Conserved Domains (4) summary
    PLN02701
    Location:44 → 980
    PLN02701; alpha-mannosidase
    cd10810
    Location:44 → 322
    GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
    smart00872
    Location:368 → 446
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:558 → 975
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    31258109..31276064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169363.5 → XP_005169420.1  lysosomal alpha-mannosidase isoform X1

    UniProtKB/TrEMBL
    A0A8M2BH83
    Conserved Domains (4) summary
    PLN02701
    Location:44 → 982
    PLN02701; alpha-mannosidase
    cd10810
    Location:44 → 322
    GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
    smart00872
    Location:368 → 446
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:558 → 977
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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